Results 151 to 160 of about 616,892 (193)

Detection of chronic wasting disease in feces and recto-anal mucosal associated lymphoid tissues with RT-QuIC in a naturally infected farmed white-tailed deer herd. [PDF]

Front Vet Sci, 2022
Tewari D, Fasnacht M, Ritzman M, Livengood J, Bower J, Lehmkuhl A, Nichols T, Hamberg A, Brightbill K, Henderson D.   +9 more
europepmc   +1 more source

alpha-synuclein RT-QuIC in cerebrospinal fluid of LRRK2-linked Parkinson's disease

, 2019
Background Leucine-rich kinase 2 (LRRK2)-linked Parkinson's disease (PD) is clinically indistinguishable from idiopathic PD (IPD). A pleiotropic neuropathology has been recognized but the majority of studies in LRRK2 p.G2019S patients reveal Lewy-type synucleinopathy as its principal histological substrate.
Garrido, A, Fairfoul, G, Tolosa, ES, Marti, MJ, Green, A, Compta, Y, Valldeoriola, F, Munoz, E, Fernandez, M, Alvarez, R, Vilas, D, Ispierto, L, De Fabregues, O, Hernandez-Vara, J, Puente, V, Calopa, M, Jauma, S, Campdelacreu, J, Bayes, A, Avila, A, Caballol, N, Aguilar, M, Casquero, P   +22 more
openaire   +1 more source

RT-QuIC detection of CWD prion seeding activity in white-tailed deer muscle tissues. [PDF]

Sci Rep, 2021
Li M, Schwabenlander MD, Rowden GR, Schefers JM, Jennelle CS, Carstensen M, Seelig D, Larsen PA.   +7 more
europepmc   +1 more source

Dementia With Lewy Bodies Phenocopy in a Case of RT-QuIC-Negative Creutzfeldt-Jakob Disease: Implications of Functional Anatomy. [PDF]

J Neuropsychiatry Clin Neurosci
Wiggins MK, Pharr EP, Wood JL, Craft S, Harrison WT, Bateman JR.   +5 more
europepmc   +1 more source

Adaptation of RT-QuIC for the detection of BSE in cattle

, 2018
Schiller, Barbara, Schmaedicke, Ann-Christin, Schuder, Angelina, Schulz-Schaeffer, Walter J., Dudas, Sandor, Motzkus, Dirk   +5 more
openaire   +1 more source

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Nanoparticle-Enhanced RT-QuIC (Nano-QuIC) Diagnostic Assay for Misfolded Proteins

Nano Letters, 2023
Misfolded proteins associated with various neurodegenerative diseases often accumulate in tissues or circulate in biological fluids years before the clinical onset, thus representing ideal diagnostic targets. Real-time quaking-induced conversion (RT-QuIC)
Peter R Christenson, Manci Li, Gage Rowden   +2 more
exaly   +4 more sources

In vivo and autopsy validation of alpha-synuclein seeding activity using RT-QuIC assay in the gastrointestinal tract of patients with Parkinson's disease

Parkinsonism and Related Disorders, 2022
OBJECTIVE In the present study, real-time quaking-induced conversion (RT-QuIC) assay was used to evaluate pathologic alpha-synuclein (AS) seeding activity in formalin-fixed paraffin-embedded (FFPE) tissue from the gastrointestinal (GI) tract of Parkinson'
Seong-Ik Kim, Seong-Ho Kong, Yun-Suhk Suh   +2 more
exaly   +2 more sources

Combined CSF α-SYN RT-QuIC, CSF NFL and midbrain-pons planimetry in degenerative parkinsonisms: From bedside to bench, and back again

Parkinsonism and Related Disorders, 2022
INTRODUCTION Differential diagnosis between Parkinson's disease (PD) and atypical parkinsonisms (APs: multiple system atrophy[MSA], progressive supranuclear palsy[PSP], corticobasal degeneration[CBD]) remains challenging. Lately, cerebrospinal fluid (CSF)
Yaroslau Compta, Cèlia Painous, Nuria Bargallo   +2 more
exaly   +2 more sources

High Diagnostic Accuracy of RT-QuIC Assay in a Prospective Study of Patients with Suspected sCJD [PDF]

International Journal of Molecular Sciences, 2020
The early and accurate in vivo diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) is essential in order to differentiate CJD from treatable rapidly progressive dementias. Diagnostic investigations supportive of clinical CJD diagnosis include magnetic
Michele Fiorini, Stefano Capaldi, Luca Sacchetto   +2 more
exaly   +4 more sources

Tracking Prions by RT-QuIC: An Update.

Sub-cellular biochemistry
C. Orrú, B. Groveman, Byron Caughey
semanticscholar   +2 more sources