Results 151 to 160 of about 424,860 (186)

Optimization of RT-QuIC Assay Duration for Screening Chronic Wasting Disease in White-Tailed Deer. [PDF]

Vet Sci
Yilmaz G, Morrill T, Pilot W, Ward C, Mitchell G, Soutyrine A, Dan H, Lin M, Guan J.   +8 more
europepmc   +1 more source

Inter-laboratory comparison of real-time quaking-induced conversion (RT-QuIC) for the detection of chronic wasting disease prions in white-tailed deer retropharyngeal lymph nodes. [PDF]

J Vet Diagn Invest
Darish JR, Kaganer AW, Hanley BJ, Schuler KL, Schwabenlander MD, Wolf TM, Ahmed MS, Rowden GR, Larsen PA, Kobashigawa E, Tewari D, Lichtenberg S, Pedersen JA, Zhang S, Sreevatsan S.   +14 more
europepmc   +1 more source

Adaptation of RT-QuIC for the detection of BSE in cattle

, 2018
Schiller, Barbara, Schmaedicke, Ann-Christin, Schuder, Angelina, Schulz-Schaeffer, Walter J., Dudas, Sandor, Motzkus, Dirk   +5 more
openaire   +1 more source

Validation of a real-time quaking-induced conversion (RT-QuIC) assay protocol to detect chronic wasting disease using rectal mucosa of naturally infected, pre-clinical white-tailed deer (Odocoileus virginianus). [PDF]

PLoS One
Piel RB, Veneziano SE, Nicholson EM, Walsh DP, Lomax AD, Nichols TA, Seabury CM, Schneider DA.   +7 more
europepmc   +1 more source

Determination of prion proteins in the diagnosis of Creutzfeldt-Jakob disease using RT-QuIC: A case report from northeastern Colombia [PDF]

Biomedica
Lizarazo J, Vargas AX, Olarte R, Lizarazo DA.   +3 more
europepmc   +1 more source

Nanoparticle-Enhanced RT-QuIC (Nano-QuIC) Diagnostic Assay for Misfolded Proteins

Nano Letters, 2023
Misfolded proteins associated with various neurodegenerative diseases often accumulate in tissues or circulate in biological fluids years before the clinical onset, thus representing ideal diagnostic targets. Real-time quaking-induced conversion (RT-QuIC)
Peter A. Larsen, Sang-Hyun Oh, Peter R. Christenson   +2 more
exaly   +4 more sources

RT-QuIC detection of tauopathies using full-length tau substrates [PDF]

Prion, 2020
Early detection and diagnosis of neurodegenerative diseases has been hampered by the lack of sensitive testing. Real-time quaking induced conversion (RT-QuIC) has been used for the early and sensitive detection of prion-induced neurologic disease, and has more recently been adapted to detect misfolded alpha-synuclein and tau as biomarkers for ...
Sarah Cooper, Davin M. Henderson, Thomas Wisniewski   +2 more
exaly   +3 more sources

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A meta-analysis on RT-QuIC for the diagnosis of sporadic CJD

Acta Neurologica Belgica, 2021
Creutzfeld-Jakob disease (CJD) is a fatal neurodegenerative disease which belongs to the family of transmissible spongiform encephalopathies (TSEs), or prion diseases. Historically, CJD diagnosis has been based on the combination of clinical features and in vivo markers, including CSF protein assays, MRI and EEG changes.
Simela Chatzikonstantinou, Dimitrios Kazis, Eleni Karantali, Mark Knights, Jack McKenna, Foivos Petridis, Ioannis Mavroudis   +6 more
openaire   +2 more sources

RT-QuIC as ultrasensitive method for prion detection

Cell and Tissue Research, 2022
Real-time quaking-induced conversion (RT-QuIC) is a cell-free abnormal form of prion protein (PrPSc) amplification method using recombinant prion protein from Escherichia coli that can measure prion seeding activity in samples with high sensitivity. The advantages of this method are that it is much more sensitive than Western blotting, which is usually
openaire   +2 more sources