Results 141 to 150 of about 616,892 (193)

Identification of α-Synuclein Proaggregator: Rapid Synthesis and Streamlining RT-QuIC Assays in Parkinson's Disease. [PDF]

ACS Med Chem Lett, 2022
Takada F, Kasahara T, Otake K, Maru T, Miwa M, Muto K, Sasaki M, Hirozane Y, Yoshikawa M, Yamaguchi J.   +9 more
europepmc   +1 more source

When Proteins Go MAD-Misfolded, Amplified, Detected: Advances in α-Synuclein Pathophysiology and RT-QuIC Detection. [PDF]

Mol Neurobiol
Labajová N, Polák A, Cehlár O, Križan P, Hritz J, Kolisek M, Škorvánek M, Škrabana R, Kovačech B, Žilka N.   +9 more
europepmc   +1 more source

Role of different recombinant PrP substrates in the diagnostic accuracy of the CSF RT-QuIC assay in Creutzfeldt-Jakob disease. [PDF]

Cell Tissue Res, 2023
Da Silva Correia SM, Schmitz M, Fischer A, Hermann P, Zerr I.   +4 more
europepmc   +1 more source

Lessons from Tau RT–QuIC: Structure, Kinetics, and Drug Discovery

The aggregation of the microtubule–associated protein tau into filamentous inclusions is a hallmark of various neurodegenerative diseases collectively known as tauopathies. This group encompasses over 20 clinicopathological conditions, including Alzheimer’s disease (AD), which accounts for about 70% of dementia cases worldwide.
openaire   +1 more source

Diagnostic testing of chronic wasting disease in white-tailed deer (Odocoileus virginianus) by RT-QuIC using multiple tissues. [PDF]

PLoS One, 2022
Burgener KR, Lichtenberg SS, Lomax A, Storm DJ, Walsh DP, Pedersen JA.   +5 more
europepmc   +1 more source

In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC. [PDF]

Neurology, 2021
Donadio V, Wang Z, Incensi A, Rizzo G, Fileccia E, Vacchiano V, Capellari S, Magnani M, Scaglione C, Stanzani Maserati M, Avoni P, Liguori R, Zou W.   +12 more
europepmc   +1 more source

Creutzfeldt-Jakob disease in pregnancy: the use of modified RT-QuIC to determine infectivity in placental tissues. [PDF]

Prion, 2021
Luk CC, Mathiason CK, Orrù CD, Jansen GH, Thiele A, Caughey B, Sim VL.   +6 more
europepmc   +1 more source

RT-QuIC Detection of Pathological α-Synuclein in Skin Punches of Patients with Lewy Body Disease. [PDF]

Mov Disord, 2021
Mammana A, Baiardi S, Quadalti C, Rossi M, Donadio V, Capellari S, Liguori R, Parchi P.   +7 more
europepmc   +1 more source

α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden [PDF]

INTRODUCTION: Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains.
Baiardi, Simone, Bateman, Randall J, Berman, Sarah B, Bernhardt, Alexander, Cairns, Nigel J, Chhatwal, Jasmeer P, Chrem, Patricio, Cruchaga, Carlos, Daniels, Alisha, Day, Gregory S, Dominantly Inherited Alzheimer, Network, Franklin, Erin E, Frosch, Matthew P, Giese, Armin, Goate, Alison M, Gordon, Brian A, Hansson, Oskar, Hofmann, Anna, Huey, Edward D, Höglinger, Günter U, Ibanez, Laura, Jucker, Mathias, Karch, Celeste M, Keene, C Dirk, Lee, Jae-Hong, Levin, Johannes, Llibre-Guerra, Jorge, Lopera, Francisco, Mammana, Angela, Masters, Colin L, McDade, Eric, McLean, Catriona, Morris, John C, Noble, James M, Parchi, Piero, Perrin, Richard J, Preische, Oliver, Quadalti, Corinne, Renton, Alan E, Roh, Jee Hoon, Rossi, Marcello, Ryan, Natalie S, Sanchez-Valle, Raquel, Schofield, Peter R, Supnet-Bell, Charlene, Vöglein, Jonathan, Xiong, Chengjie   +46 more
core  

In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC. [PDF]

Neurology, 2022
europepmc   +1 more source