Performance of a seed amplification assay for misfolded alpha-synuclein in cerebrospinal fluid and brain tissue in relation to Lewy body disease stage and pathology burden [PDF]
The development of in vitro seed amplification assays (SAA) detecting misfolded alpha-synuclein (alpha Syn) in cerebrospinal fluid (CSF) and other tissues has provided a pathology-specific biomarker for Lewy body disease (LBD).
Baiardi, Simone +10 more
core +1 more source
Development of TDP-43 RT-QuIC method
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2023 Sora Sakamoto +3 more
openaire +1 more source
Diagnosing Sporadic Creutzfeldt-Jakob Disease by the Detection of Abnormal Prion Protein in Patient Urine [PDF]
, 2016 IMPORTANCE: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disorder associated with the accumulation of infectious abnormal prion protein through a mechanism of templated misfolding.
Collinge, J +7 more
core +1 more source
PLoS ONE, 2018 Scrapie is a naturally occurring transmissible spongiform encephalopathy of sheep and goats. This fatal neurodegenerative disease is caused by misfolding of the cellular prion protein to pathogenic β-rich conformers (PrPSc) that accumulate in higher ...
Soyoun Hwang +3 more
doaj +1 more source
RT-QuIC for detection of prodromal α-synucleinopathies
The Lancet Neurology, 2021 openaire +3 more sources
RT-QuIC analysis of peripheral tissues and body fluids collected from patients with primary and secondary tauopathies [PDF]
, 2019 Neurodegenerative diseases(NDs)are fatal and incurable conditionscharacterized bythe progressive accumulation in specific brain regions of abnormally folded(misfolded)proteins, which are considered disease-specific biomarkers (DSB).These ...
Rossi, Martina
core
Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces.
PLoS PathogensPrions or prion-like aggregates such as those composed of PrP, α-synuclein, and tau are key features of proteinopathies such as prion, Parkinson's and Alzheimer's diseases, respectively.
Christina D Orrú +13 more
doaj +1 more source
Prions propagate as multiple strains in a wide variety of mammalian species. The detection of all such strains by a single ultrasensitive assay such as Real Time Quaking-induced Conversion (RT-QuIC) would facilitate prion disease diagnosis, surveillance ...
core
Ante-mortem detection of chronic wasting disease in recto-anal mucosa-associated lymphoid tissues from elk (\u3ci\u3eCervus elaphus nelsoni\u3c/i\u3e) using real-time quaking-induced conversion (RT-QuIC) assay: A blinded collaborative study [PDF]
, 2017 Prion diseases are transmissible spongiform encephalopathies (TSEs) characterized by fatal, progressive neurologic diseases with prolonged incubation periods and an accumulation of infectious misfolded prion proteins.
Dutta, Somak +8 more
core +1 more source