Results 111 to 120 of about 616,892 (193)

Are PARKIN patients ideal candidates for dopaminergic cell replacement therapies? [PDF]

, 2018
Parkinson's is a heterogeneous, complex condition. Stratification of Parkinson's subtypes will be essential to identify those that will benefit most from a cell replacement therapy.
Chan, Claire, Chen, Yixi, Khan, Sadaquate, Kunath, Tilo, Muqit, Miratul M. K., Natalwala, Ammar, Stecher, Benjamin, Taylor, Martin   +7 more
core   +3 more sources

A Novel 3D Semi‐Automated Full Quantification Technique for Detection of Intraneural Phospho‐α‐Synuclein in Skin Biopsies

European Journal of Neurology, Volume 33, Issue 4, April 2026.
A novel semi‐automated 3D immunofluorescence technique enables full volumetric quantification of intraneural phospho‐α‐synuclein load in skin biopsies. It refines conventional visually based signal assessment through a more objective, computer‐assisted procedure and provides burden‐dependent test results important for differential diagnostics.
Sophia Lonczewski, Verian Bader, Louisa Ortmann, Louisa Basner, Markus Stücker, Ralf Gold, Raphael Scherbaum, Eun Hae Kwon, Konstanze F. Winklhofer, Lars Tönges   +9 more
wiley   +1 more source

Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression [PDF]

, 2018
OBJECTIVES: A blood-based biomarker of neuronal damage in sporadic Creutzfeldt-Jakob disease (sCJD) will be extremely valuable for both clinical practice and research aiming to develop effective therapies.
Collinge, J, Heslegrave, AJ, Jackson, GS, Luk, C, Mead, SH, Thompson, AGB, Zetterberg, H   +6 more
core   +1 more source

Prion-specific and surrogate CSF biomarkers in Creutzfeldt-Jakob disease:diagnostic accuracy in relation to molecular subtypes and analysis of neuropathological correlates of p-tau and A beta 42 levels [PDF]

, 2017
The differential diagnosis of Creutzfeldt-Jakob disease (CJD) from other, sometimes treatable, neurological disorders is challenging, owing to the wide phenotypic heterogeneity of the disease.
A Bertrand, A Dorey, A Karch, A Ladogana, A Plate, Alessia Franceschini, Alison Green, Anna Ladogana, B Ghetti, B Sikorska, B Van Everbroeck, B Van Everbroeck, C Hamlin, C Jansen, CA Goodall, CD Orrú, CD Orrú, D Strozyk, D Varges, E Kapaki, F Caobelli, Francesca Lattanzio, G Chohan, G Giaccone, G Giaccone, G Puoti, G Zanusso, G Zanusso, GG Kovacs, GG Kovacs, Giulia Amore, GM McKhann, H Assar, H Braak, Hideaki Kai, I Alafuzoff, I Alafuzoff, I Sala, I Zerr, I Zerr, IE Baldeiras, Ilaria Poggiolini, J Beck, J Wiltfang, J Wiltfang, JF Crary, JH Park, K Blennow, K Buerger, K Buerger, K Gmitterová, K Sano, K Stoeck, KA Josephs, L Reiniger, LI McGuire, LI McGuire, Lynne McGuire, M Cramm, M Otto, M Otto, M Riemenschneider, Marcello Rossi, Maurizio Pocchiari, MB Coulthart, MD Geschwind, MD Geschwind, MD Geschwind, MH Rosenbloom, MW Head, N Chitravas, N Mattsson, P Lewczuk, P Parchi, P Parchi, P Parchi, P Parchi, P Parchi, P Parchi, P Sanchez-Juan, Piero Parchi, R Atarashi, RG Will, RJ Castellani, S Abu Rumeileh, S Capellari, Sabina Capellari, Samir Abu-Rumeileh, SB Prusiner, Simone Baiardi, T Muayqil, T Skillbäck, T Tapiola, TT Seppälä, WQ Zou   +94 more
core   +2 more sources

Ten‐Year Retrospective Study on the Diagnostic Value of Three‐Site Skin Biopsy for Detecting pS129‐α‐Synuclein Biomarker: Cervical and Leg Dual‐Site Biopsy as an Effective and Less Invasive Alternative

European Journal of Neurology, Volume 33, Issue 3, March 2026.
This study evaluated the diagnostic accuracy of different skin biopsy site combinations for in vivo detection of phosphorylated‐α‐synuclein, aiming to identify a standardised and less invasive sampling strategy. In a 10‐year retrospective cohort of 227 patients with Lewy body diseases or multiple system atrophy, the cervical plus distal leg combination
Cecilia Delprete, Alex Incensi, Alessandro Furia, Cosmanna Ragucci, Riccardo Bari, Veria Vacchiano, Maria Pia Giannoccaro, Giovanni Rizzo, Rocco Liguori, Vincenzo Donadio   +9 more
wiley   +1 more source

Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic creutzfeldt–jakob disease:An international study [PDF]

, 2016
Real-time quaking-induced conversion (RT-QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt\u2013Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to ...
Atarashi , Ryuichiro, Cheng , Keding, Collins, Steven, Cramm , Maria, Cras , Patrick, de Vil , Bart, Equestre, Michele, Fairfoul , Graham, Green, Alison, Grznarova , Katarina, Haik, Stéphane, Knox , David, McGuire, Lynne I., Parchi, Piero, Pocchiari, Maurizio, Poggiolini , Ilaria, Poleggi, Anna, Sarros , Shannon, Satoh, Katsuya, Schmitz, Matthias, Shi , Song, Suardi, Silvia, Tagliavini, Fabrizio, Zerr, Inga   +23 more
core   +3 more sources

Quaking-induced conversion of prion protein on a thermal mixer accelerates detection in brains infected with transmissible spongiform encephalopathy agents.

PLoS ONE, 2019
Detection of misfolded prion protein, PrPTSE, in biological samples is important to develop antemortem tests for transmissible spongiform encephalopathies (TSEs).
Nadine Kaelber, Cyrus Bett, David M Asher, Luisa Gregori   +3 more
doaj   +1 more source

Rapid antemortem detection of CWD prions in deer saliva. [PDF]

PLoS ONE, 2013
Chronic wasting disease (CWD) is an efficiently transmitted prion disease of cervids, now identified in 22 United States, 2 Canadian provinces and Korea.
Davin M Henderson, Matteo Manca, Nicholas J Haley, Nathaniel D Denkers, Amy V Nalls, Candace K Mathiason, Byron Caughey, Edward A Hoover   +7 more
doaj   +1 more source

Classification of tauopathies from human brain homogenates through salt‐modulated tau amplification

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Tauopathies are a heterogeneous group of neurodegenerative disorders defined by abnormal aggregation of tau protein. Although cryogenic electron microscopy (cryo‐EM) has uncovered disease‐specific tau structures, translating these insights into diagnostic tools remains difficult. METHODS We developed a heparin‐free, salt‐modulated
Alessia Santambrogio, Michael A. Metrick II, Peifeng Xu, Nicholas C. T. Gallagher, Shunsuke Koga, Bernardino Ghetti, Dennis W. Dickson, Byron Caughey, Michele Vendruscolo   +8 more
wiley   +1 more source

Prodromal Lewy Body Symptoms and α‐Synuclein Seeding in Idiopathic Olfactory Dysfunction

Movement Disorders Clinical Practice, Volume 13, Issue 2, Page 494-502, February 2026.
Abstract Background Early identification of pathological α‐synuclein deposition (αSynD) may improve understanding of Lewy body disorder (LBD) progression and enable timely disease‐modifying treatments. Objectives We investigated αSynD using a seed amplification assay and assessed prodromal LBD symptoms in individuals with idiopathic olfactory ...
Oskar Hoffmann McWilliam, Remarh Bsoul, Gunhild Waldemar, Steen Gregers Hasselbalch, Anja Hvid Simonsen, Marie Bruun, Laura Storm Næsborg Andersen, Christian von Buchwald, Kasper Aanæs, Christian K. Pedersen, Ida S.B. Andersen, Magne Bech, Clara Hageman Pinborg, Aušrinė Areškevičiūtė, Eva Løbner Lund, Kristian Steen Frederiksen   +15 more
wiley   +1 more source