Results 91 to 100 of about 424,860 (186)

Seed Amplification Assays for Parkinson's Disease: A Review of α‐Synuclein Assays in Body Fluids and Tissues

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Background: Parkinson's disease (PD) diagnosis is hindered by late motor symptom onset and low specificity of clinical assessments. This systematic review and meta‐analysis evaluates α‐synuclein seed amplification assays (SAAs) for PD and related synucleinopathies. Main Results: SAAs, including real‐time quaking‐induced conversion (RT‐QuIC) and protein
Weijie Kong, Katsuya Satoh, Mika Inada Shimamura, Tetsuya Maeda, Kenta Takahashi, Masanori Kurihara, Atsushi Iwata   +6 more
wiley   +1 more source

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, Volume 13, Issue 4, Page 827-833, April 2026.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source

Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Microglia have been implicated in the templated spread of tau aggregates in tauopathies through mouse studies. However, it is unclear whether these findings translate to human disease. METHODS We challenged human induced pluripotent stem cell (iPSC)‐derived microglia‐like‐cells (iMGL) with monomeric and fibrillar recombinant tau ...
Maria Kreger Karabova, Anna del Ser‐Badia, Anne Hedegaard, Sam J. Washer, Zeynep Baykam, Darragh P. O'Brien, Iolanda Vendrell, Svenja S. Hester, Roman Fischer, Errin Johnson, Charlotte E. Melia, Teige R. S. Matthews‐Palmer, Rishi Matadeen, Alessia Santambrogio, Michael A. Metrick II, Michele Vendruscolo, Sophie Keeling, Kimberly Ai Xian Cheam, William A. McEwan, Kenneth S. Kosik, Theresa A. Day, William S. James, Sally A. Cowley   +22 more
wiley   +1 more source

Graphical summary of the RT-QuIC reactions results.

, 2019
Each data point represents the time (in hours) at which an individual reaction well reached the threshold of fluorescence for positivity (Time to Threshold, TtoT). Technical replicates per individual seed are displayed in columns.
Gabriele Piconi (6848594), Alexander H. Peden (6848597), Alison J. E. Green (757642), Marcelo A. Barria (264036)   +3 more
core   +1 more source

Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies

Experimental Gerontology
synucleinopathies are diseases characterized by the aggregation of α-synuclein (α-syn), which forms fibrils through misfolding and accumulates in a prion-like manner.
Juan Huang, Xingxing Yuan, Lin Chen, Binbin Hu, Hui Wang, Ye Wang, Wei Huang   +6 more
doaj   +1 more source

Comparison of IHC and NAPTA RT-QuIC detection in tonsil and RAMALT biopsies.

, 2020
Each plot displays a 12-month timeframe where deer became IHC positive for the first time. Months post inoculation is on the x-axis and RT-QuIC reaction rate is displayed on the y-axis.
Lauren A. Bracchi (8452077), Nathaniel D. Denkers (8452071), Edward A. Hoover (7321355), Erin E. McNulty (8452074), Clare E. Hoover (4419688), Candace K. Mathiason (7321352), Davin M. Henderson (7321346), Sarah K. Cooper (7321343)   +7 more
core   +1 more source

QUIC protocol impact on the OSI layer 7

, 2023
reservedIn questa tesi viene analizzato il QUIC, un nuovo protocollo proposto da Google per le trasmissioni Web in alternativa alle tradizionali connessioni basate su TCP.
RIGOBELLO, MANUEL
core  

Comparison of IHC and RT-QuIC detection in tonsil and RAMALT biopsies.

, 2020
Each plot displays a 12-month timeframe where deer became IHC positive for the first time. Months post inoculation is on the x-axis and RT-QuIC reaction rate is displayed on the y-axis.
Lauren A. Bracchi (8452077), Nathaniel D. Denkers (8452071), Edward A. Hoover (7321355), Erin E. McNulty (8452074), Clare E. Hoover (4419688), Candace K. Mathiason (7321352), Davin M. Henderson (7321346), Sarah K. Cooper (7321343)   +7 more
core   +1 more source

Aqueous extraction of formalin-fixed paraffin-embedded tissue and detection of prion disease using real-time quaking-induced conversion

BMC Research Notes
Objective The goal of the research presented here is to determine if methods previously developed for the aqueous extraction of PrPSc from formalin-fixed paraffin-embedded tissue (FFPET) are applicable to the detection PrPSc by real-time quaking induced ...
Eric M. Nicholson, Justin J. Greenlee, Soyoun Hwang   +2 more
doaj   +1 more source

End-point RT-QUIC analysis of 10 brain specimens from patients with prion diseases.

, 2015
End-point RT-QUIC assay was performed three times. (a) Brain tissues from six patients with sCJD-MM1 were used to seed the RT-QUIC reaction. (b) Samples of GSS-P102L, sCJD-MV2, and sCJD-MM2 (cortical and thalamic forms) were used to seed RT-QUIC reaction.
Katsuya Satoh (286748), Takehiro Nakagaki (754163), Ban Mihara (754165), Takayuki Fuse (754162), Mari Yoshida (286757), Kazunori Sano (236045), Ryuichiro Atarashi (236043), Tsuyoshi Mori (140609), Masaki Takao (754166), Yasushi Iwasaki (286755), Noriyuki Nishida (286767), Hanae Takatsuki (754161), Daisuke Ishibashi (754164)   +12 more
core   +1 more source