Results 81 to 90 of about 424,860 (186)
Acta Neuropathologica Communications, 2020 Multiple neurodegenerative diseases are characterized by aggregation of tau molecules. Adult humans express six isoforms of tau that contain either 3 or 4 microtubule binding repeats (3R or 4R tau).
Michael A. Metrick +8 more
doaj +1 more source
Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation
Advanced Science, Volume 13, Issue 27, 13 May 2026.Nanoplastics are pervasive environmental contaminants with potentially profound implications for human health. Emerging evidence suggests a possible link between nanoplastic exposure and neurodegeneration, a key driver of ageing and dementia, yet causality remains unresolved.
Yuhuan Li +5 more
wiley +1 more source
RT-QuIC sodium chloride titration for scrapie-infected and uninfected sheep brain samples.
, 2018 RT-QuIC reactions were seeded with 10−2 brain homogenate of animal number 2 (ARQ/ARQ;x124) using full-length elk prion protein 132L (a) and 132M (b) using a range of NaCl concentrations (100–500 mM, 100 mM: blue, 200 mM: red, 300 mM:green, 400 mM: purple,
Natalie M. Vance (6107846) +3 more
core +2 more sources
Annals of Neurology, Volume 99, Issue 5, Page 1303-1314, May 2026.Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw +13 more
wiley +1 more source
RT-QuIC analysis for treatments of WTD-1 coated wires.
, 2019 All wires were exposed to 10−2 WTD-1 CWD-positive brain homogenate, washed and allowed to dry before treatment. Wires were then immersed in either water or bleach treatments, briefly rinsed and dried before being placed into RT-QuIC plate wells for ...
Katie Williams (6166097) +3 more
core +1 more source
, 2020 RT-QuIC reactions were seeded with EIA normalized stock (a), 10−1 (b), 10−2 (c), and 10−3 (d) dilutions of three CWD infected WTD brains and one negative animal.
Justin J. Greenlee (8262051) +2 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.MOG antibody‐associated cortical encephalitis (MOG‐CCE) presents a distinct clinical phenotype characterized by seizure‐dominant onset, unilateral cortical lesions, and favorable immunotherapy response, highlighting the diagnostic and prognostic value of antibody profiling in autoimmune cortical encephalitis.
Qing Yin +7 more
wiley +1 more source
PLoS ONE, 2019 Detection of misfolded prion protein, PrPTSE, in biological samples is important to develop antemortem tests for transmissible spongiform encephalopathies (TSEs).
Nadine Kaelber +3 more
doaj +1 more source
Brain Pathology, Volume 36, Issue 3, May 2026.The study analyzed the seeding activity of misfolded tau protein in Alzheimer's disease and rapidly progressive Alzheimer's disease patients and provides evidence for the existence of different tau assemblies supported by differences in cellular toxicity and morphology of thioflavin T‐positive real‐time quaking‐induced conversion products.
Matthias Schmitz +13 more
wiley +1 more source
, 2019 Lane 1–6: RT-QuIC reaction products from reactions seeded with sCJD subtypes MM1, MM2, MV1, MV2, VV1, VV2, respectively. Lane 7: products of RT-QuIC reactions seeded with non-CJD 10%BH. Lane 8: unseeded RT-QuIC reaction products.
Gabriele Piconi (6848594) +3 more
core +1 more source