Results 81 to 90 of about 2,250 (151)

Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces.

PLoS Pathogens
Prions or prion-like aggregates such as those composed of PrP, α-synuclein, and tau are key features of proteinopathies such as prion, Parkinson's and Alzheimer's diseases, respectively.
Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C Ferreira, Pierluigi Gambetti, David A Schneider, Kentaro Masujin, Kohtaro Miyazawa, Bernardino Ghetti, Gianluigi Zanusso, Byron Caughey   +13 more
doaj   +1 more source

An atypical case of Creutzfeldt-Jakob disease mimicking frontotemporal dementia: genotypic influence and clinical implications

BMC Geriatrics
We report an atypical case of Creutzfeldt-Jakob Disease (CJD) mimicking Frontotemporal Dementia (FTD) in a 68-year-old male. The patient initially presented with an anxious-depressive syndrome, progressing over 29 months to include dysexecutive syndrome,
Carlo Manco, Delia Righi, Barbara Pucci, Bruno Damiano, Andrea Mignarri, Nicola De Stefano, Domenico Plantone   +6 more
doaj   +1 more source

Salivary α-Synuclein RT-QuIC Correlates with Disease Severity in de novo Parkinson's Disease. [PDF]

Mov Disord, 2023
Vivacqua G, Mason M, De Bartolo MI, Węgrzynowicz M, Calò L, Belvisi D, Suppa A, Fabbrini G, Berardelli A, Spillantini M.   +9 more
europepmc   +1 more source

Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder. [PDF]

Neurology, 2023
Iranzo A, Mammana A, Muñoz-Lopetegi A, Dellavalle S, Mayà G, Rossi M, Serradell M, Baiardi S, Arqueros A, Quadalti C, Perissinotti A, Ruggeri E, Cano JS, Gaig C, Parchi P.   +14 more
europepmc   +1 more source

Identification of α-Synuclein Proaggregator: Rapid Synthesis and Streamlining RT-QuIC Assays in Parkinson's Disease. [PDF]

ACS Med Chem Lett, 2022
Takada F, Kasahara T, Otake K, Maru T, Miwa M, Muto K, Sasaki M, Hirozane Y, Yoshikawa M, Yamaguchi J.   +9 more
europepmc   +1 more source

Comparison of acetone and sodium phosphotungstic acid precipitation for sample enrichment prior to RT-QuIC for the detection of prion disease. [PDF]

BMC Res Notes
Nicholson EM, Veneziano SE.
europepmc   +1 more source

When Proteins Go MAD-Misfolded, Amplified, Detected: Advances in α-Synuclein Pathophysiology and RT-QuIC Detection. [PDF]

Mol Neurobiol
Labajová N, Polák A, Cehlár O, Križan P, Hritz J, Kolisek M, Škorvánek M, Škrabana R, Kovačech B, Žilka N.   +9 more
europepmc   +1 more source

Role of different recombinant PrP substrates in the diagnostic accuracy of the CSF RT-QuIC assay in Creutzfeldt-Jakob disease. [PDF]

Cell Tissue Res, 2023
Da Silva Correia SM, Schmitz M, Fischer A, Hermann P, Zerr I.   +4 more
europepmc   +1 more source

Biochemical signatures of skin α-synuclein in synucleinopathies revealed by RT-QuIC assay end-product analysis. [PDF]

Acta Neuropathol
Gerasimenko M, Yi H, Gilliland T, Chen Y, Wang Z, Zou WQ.   +5 more
europepmc   +1 more source

Diagnostic testing of chronic wasting disease in white-tailed deer (Odocoileus virginianus) by RT-QuIC using multiple tissues. [PDF]

PLoS One, 2022
Burgener KR, Lichtenberg SS, Lomax A, Storm DJ, Walsh DP, Pedersen JA.   +5 more
europepmc   +1 more source