Anti-Prion Screening for Acridine, Dextran, and Tannic Acid using Real Time-Quaking Induced Conversion: A Comparison with PrPSc-Infected Cell Screening. [PDF]
PLoS ONE, 2017 Prion propagation is mediated by the structural alteration of normal prion protein (PrPC) to generate pathogenic prion protein (PrPSc). To date, compounds for the inhibition of prion propagation have mainly been screened using PrPSc-infected cells.
Jae Wook Hyeon +6 more
doaj +1 more source
Frontiers in Veterinary Science, 2022 Chronic wasting disease (CWD) is a transmissible prion disorder, primarily affecting free-ranging and captive cervids in North America (United States and Canada), South Korea, and Europe (Finland, Norway, and Sweden).
Carine L. Holz +6 more
doaj +1 more source
Exploring physical and chemical factors influencing the properties of recombinant prion protein and the real-time quaking-induced conversion (RT-QuIC) assay. [PDF]
PLoS ONE, 2014 Real-time quaking-induced conversion (RT-QuIC), a highly specific and sensitive assay able to detect low levels of the disease-inducing isoform of the prion protein (PrP(d)) in brain tissue biopsies and cerebral spinal fluid, has great potential to ...
Keding Cheng +5 more
doaj +1 more source
Acta Neuropathologica, 2020 The clinical diagnosis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), is challenging, especially at an early disease stage, due to the heterogeneous and often non-specific ...
Marcello Rossi +14 more
semanticscholar +1 more source
Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease [PDF]
, 2012 OBJECTIVE: Current cerebrospinal fluid (CSF) tests for sporadic Creutzfeldt-Jakob disease (sCJD) are based on the detection of surrogate markers of neuronal damage such as CSF 14-3-3 which are not specific for sCJD.
Andrews, Mary +11 more
core +1 more source
THE DIAGNOSTIC UTILITY OF RT-QUIC IN SPORADIC CJD [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 2014 Sporadic CJD (sCJD) remains the commonest type of CJD. Currently, there is not a disease specific antemortem test available for the diagnosis of sCJD with postmortem remaining the definitive method of diagnosis. Current diagnostic criteria rely on clinical presentation in association with the MRI, EEG and CSF 14–3–3 protein.
Louise Davidson +4 more
openaire +1 more source
Frontiers in Veterinary Science, 2018 Bovine spongiform encephalopathy (BSE) belongs to a group of fatal prion diseases that result from the misfolding of the cellular prion protein (PrPC) into a pathogenic form (PrPSc) that accumulates in the brain.
Soyoun Hwang +5 more
doaj +1 more source
Prion Seeding Activities of Mouse Scrapie Strains with Divergent PrPSc Protease Sensitivities and Amyloid Plaque Content Using RT-QuIC and eQuIC [PDF]
, 2012 Different transmissible spongiform encephalopathy (TSE)-associated forms of prion protein (e.g. PrPSc) can vary markedly in ultrastructure and biochemical characteristics, but each is propagated in the host. PrPSc propagation involves conversion from its
AH Peden +70 more
core +3 more sources
Imaging and CSF analyses effectively distinguish CJD from its mimics [PDF]
, 2017 OBJECTIVE: To review clinical and investigation findings in patients referred to a specialist prion clinic who were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to have an alternative final diagnosis. METHODS: Review the
Collinge, J +4 more
core +1 more source
High sensitivity of an ELISA kit for detection of the gamma-isoform of 14-3-3 proteins: usefulness in laboratory diagnosis of human prion disease [PDF]
, 2011 Background The gamma-isoform of the 14-3-3 protein (14-3-3 gamma) is expressed in neurons, and could be a specific marker for neuronal damage.
Yuki Matsui +8 more
core +1 more source