Results 61 to 70 of about 424,860 (186)
CSF seeded RT-QuIC reaction kinetic and PK resistant RT-QuIC reaction products.
, 2019 (A) Averaged RT-QuIC traces per individual seed are displayed (B) RT-QuIC reaction products from the reaction displayed in (A) were digested with PK 50 ug/mL and probed in WB with mAb SAF70 1:1000.
Gabriele Piconi (6848594) +3 more
core +1 more source
Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays
Biomolecules, 2020 Neurodegenerative diseases are characterized by the accumulation of disease-related misfolded proteins. It is now widely understood that the characteristic self-amplifying (i.e., seeding) capacity once only attributed to the prions of transmissible ...
Matteo Manca, Allison Kraus
doaj +1 more source
Concurrent Hashimoto's Encephalopathy and Papillary Thyroid Carcinoma: A Case Report
Clinical and Experimental Neuroimmunology, Volume 17, Issue 3, August 2026.ABSTRACT Background Hashimoto's encephalopathy (HE) is a rare steroid‐responsive autoimmune syndrome. Although HE is associated with anti‐thyroid antibodies, its concurrence with malignant thyroid tumors has rarely been described and its clinical implications remain poorly understood.
Ryo Hara +12 more
wiley +1 more source
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.Abstract INTRODUCTION Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are neurocognitive disorders characterized by distinct but often overlapping pathological processes. These include α‐synuclein, amyloid‐beta 42 (Aβ42), and tau protein aggregation. While cerebrospinal fluid (CSF) biomarkers provide in vivo insight into these pathologies,
Vincent Gabriel +12 more
wiley +1 more source
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, Volume 36, Issue 4, July 2026.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
Performance Analysis of QUIC Protocol Used for Real-World Automated Meter Reading Application [PDF]
, 2022 openThe QUIC is a new encrypted transport protocol, designed on the basis of decades of transport and security experience, with the aim to find a valid, more performing substitute to TCP protocol in all its internet implications.
MILOVANOVIC, BOGDAN
core
Endpoint dilution of prion-infected brain homogenates by RT-QuIC.
, 2023 Representative RT-QuIC experiments testing a ten-fold dilution series of (A) reference BSE-infected sheep brain tissue and brain tissue from mock-infected negative control sheep (NBH), and (B) reference vCJD-infected human brain tissue and negative ...
M. Khalid F. Salamat (10163942) +7 more
core +1 more source
PLoS ONE, 2019 Sporadic Creutzfeldt-Jakob disease (sCJD) is a transmissible, rapidly progressive and fatal neurodegenerative disease. The transmissible agent linked to sCJD is composed of the misfolded form of the host-encoded prion protein.
Gabriele Piconi +3 more
doaj +1 more source
Brain Pathology, Volume 36, Issue 4, July 2026.A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña +20 more
wiley +1 more source
Rapid and Sensitive RT-QuIC Detection of Human Creutzfeldt-Jakob Disease Using Cerebrospinal Fluid
mBio, 2015 Fast, definitive diagnosis of Creutzfeldt-Jakob disease (CJD) is important in assessing patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) assays of cerebrospinal fluid (CSF) and nasal-brushing specimens are ...
Christina D. Orrú +5 more
doaj +1 more source