Results 51 to 60 of about 2,250 (151)
Concurrent Hashimoto's Encephalopathy and Papillary Thyroid Carcinoma: A Case Report
Clinical and Experimental Neuroimmunology, Volume 17, Issue 3, August 2026.ABSTRACT Background Hashimoto's encephalopathy (HE) is a rare steroid‐responsive autoimmune syndrome. Although HE is associated with anti‐thyroid antibodies, its concurrence with malignant thyroid tumors has rarely been described and its clinical implications remain poorly understood.
Ryo Hara +12 more
wiley +1 more source
Stability and Reproducibility Underscore Utility of RT-QuIC for Diagnosis of Creutzfeldt-Jakob Disease [PDF]
Molecular Neurobiology, 2015 Abstract Real-time quaking-induced conversion (RT-QuIC) allows the amplification of miniscule amounts of scrapie prion protein (PrPSc). Recent studies applied the RT-QuIC methodology to cerebrospinal fluid (CSF) for diagnosing human prion diseases.
Cramm, M +11 more
openaire +5 more sources
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, Volume 36, Issue 4, July 2026.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
Brain Pathology, Volume 36, Issue 4, July 2026.A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña +20 more
wiley +1 more source
A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu +4 more
wiley +1 more source
Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation
Advanced Science, Volume 13, Issue 27, 13 May 2026.Nanoplastics are pervasive environmental contaminants with potentially profound implications for human health. Emerging evidence suggests a possible link between nanoplastic exposure and neurodegeneration, a key driver of ageing and dementia, yet causality remains unresolved.
Yuhuan Li +5 more
wiley +1 more source
Preparation of mouse tissue homogenates for RT-QuIC assay v1
, 2023 This protocol is designed for a standardized and efficient procedure to homogenize mouse tissue, conducive for RT-QuIC analysis. The process involves treating samples with PBS mixed with Triton-X100, followed by homogenization using a prob-tip sonicator.
arpine.sokratian not provided +1 more
openaire +1 more source
Annals of Neurology, Volume 99, Issue 5, Page 1303-1314, May 2026.Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw +13 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.MOG antibody‐associated cortical encephalitis (MOG‐CCE) presents a distinct clinical phenotype characterized by seizure‐dominant onset, unilateral cortical lesions, and favorable immunotherapy response, highlighting the diagnostic and prognostic value of antibody profiling in autoimmune cortical encephalitis.
Qing Yin +7 more
wiley +1 more source