Epitope mapping of the protease resistant products of RT-QuIC does not allow the discrimination of sCJD subtypes. [PDF]
PLoS ONE, 2019 Sporadic Creutzfeldt-Jakob disease (sCJD) is a transmissible, rapidly progressive and fatal neurodegenerative disease. The transmissible agent linked to sCJD is composed of the misfolded form of the host-encoded prion protein.
Gabriele Piconi +3 more
doaj +3 more sources
Rapid and Sensitive RT-QuIC Detection of Human Creutzfeldt-Jakob Disease Using Cerebrospinal Fluid [PDF]
mBio, 2015 Fast, definitive diagnosis of Creutzfeldt-Jakob disease (CJD) is important in assessing patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) assays of cerebrospinal fluid (CSF) and nasal-brushing specimens are ...
Christina D. Orrú +5 more
doaj +3 more sources
Preparation of lyophilized recombinant prion protein for TSE diagnosis by RT-QuIC [PDF]
BMC Research Notes, 2018 Objective Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases, often referred as prion diseases. TSEs result from the misfolding of the cellular prion protein (PrPC) into a pathogenic form (PrPSc) that ...
Soyoun Hwang +3 more
doaj +3 more sources
An atypical case of Creutzfeldt-Jakob disease mimicking frontotemporal dementia: genotypic influence and clinical implications [PDF]
BMC GeriatricsWe report an atypical case of Creutzfeldt-Jakob Disease (CJD) mimicking Frontotemporal Dementia (FTD) in a 68-year-old male. The patient initially presented with an anxious-depressive syndrome, progressing over 29 months to include dysexecutive syndrome,
Carlo Manco +6 more
doaj +2 more sources
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies [PDF]
, 2021 Several studies have confirmed α-synuclein real-time quaking-induced conversion (αSyn-RT-QuIC) assay to have high sensitivity and specificity for Parkinson's disease.
Antelmi, Elena +20 more
core +10 more sources
Frontiers in Aging Neuroscience, 2022 The real-time quaking-induced conversion (RT-QuIC) assay has been developed and used as an in vitro diagnostic tool for Parkinson’s disease (PD). In this study, we established α-Syn RT-QuIC using recombinant human α-Syn as the substrate.
Dong-Dong Chen +12 more
doaj +1 more source
Improved Real-Time Quaking Induced Conversion for Early Diagnostics of Creutzfeldt-Jakob Disease in Denmark [PDF]
, 2023 Cerebrospinal fluid-based real-time quaking-induced conversion (CSF RT-QuIC) is currently the most prominent method for early detection of sporadic Creutzfeldt–Jakob disease (sCJD), the most common prion disease.
Andrews, Mary +6 more
core +2 more sources
Diagnosis of prion diseases by RT-QuIC results in improved surveillance [PDF]
Neurology, 2020 To present the National Prion Disease Pathology Surveillance Center's (NPDPSC's) experience using CSF real-time quaking-induced conversion (RT-QuIC) as a diagnostic test, to examine factors associated with false-negative RT-QuIC results, and to investigate the impact of RT-QuICs on prion disease surveillance.Between May 2015 and April 2018, the NPDPSC ...
Daniel D. Rhoads +11 more
openaire +2 more sources
Brain and Cerebrospinal Fluid α-Synuclein Real-Time Quaking-Induced Conversion Identifies Lewy Body Pathology in LRRK2-PD [PDF]
, 2022 Background<jats:p/>The neuropathology of Parkinson's disease (PD) associated with leucine‐rich repeat kinase 2 (LRRK2) mutations (LRRK2‐PD) is heterogeneous and varies with the type of mutation.
Ezquerra, Mario +5 more
core +3 more sources
Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear
Scientific Reports, 2021 Efforts to contain the spread of chronic wasting disease (CWD), a fatal, contagious prion disease of cervids, would be aided by the availability of additional diagnostic tools.
Natalia C. Ferreira +13 more
doaj +1 more source