Results 71 to 80 of about 2,250 (151)

Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies

Experimental Gerontology
synucleinopathies are diseases characterized by the aggregation of α-synuclein (α-syn), which forms fibrils through misfolding and accumulates in a prion-like manner.
Juan Huang, Xingxing Yuan, Lin Chen, Binbin Hu, Hui Wang, Ye Wang, Wei Huang   +6 more
doaj   +1 more source

Aqueous extraction of formalin-fixed paraffin-embedded tissue and detection of prion disease using real-time quaking-induced conversion

BMC Research Notes
Objective The goal of the research presented here is to determine if methods previously developed for the aqueous extraction of PrPSc from formalin-fixed paraffin-embedded tissue (FFPET) are applicable to the detection PrPSc by real-time quaking induced ...
Eric M. Nicholson, Justin J. Greenlee, Soyoun Hwang   +2 more
doaj   +1 more source

Real time-quaking induced conversion assay (RT-QUIC) v1

, 2022
Seeded-amplification assay (SAA) method for the detection of pathology-associated aggregation-templating competent forms of alpha-synuclein and other interacting factors.
andrew.west west, Arpine Sokratian
openaire   +1 more source

Adult‐Onset Acute Cerebellar Ataxia with Preceding Essential Tremor‐like Syndrome Associated with a Novel Variant in ATP1A3

Movement Disorders Clinical Practice, Volume 13, Issue 3, Page 832-834, March 2026.
Lukas Gattermeyer‐Kell, Sebastian Franthal, Maria Tscherner, Mariella Kögl, Petra Katschnig‐Winter, Christian Windpassinger, Petra Schwingenschuh   +6 more
wiley   +1 more source

RT-QuIC for detection of prodromal α-synucleinopathies

The Lancet Neurology, 2021
openaire   +3 more sources

Development of TDP-43 RT-QuIC method

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2023
Sora Sakamoto, Masatoshi Inden, Takayoshi Shimohata, Ryo Honda   +3 more
openaire   +1 more source

Source genotype influence on cross species transmission of transmissible spongiform encephalopathies evaluated by RT-QuIC.

PLoS ONE, 2018
Scrapie is a naturally occurring transmissible spongiform encephalopathy of sheep and goats. This fatal neurodegenerative disease is caused by misfolding of the cellular prion protein to pathogenic β-rich conformers (PrPSc) that accumulate in higher ...
Soyoun Hwang, Justin J Greenlee, Natalie M Vance, Eric M Nicholson   +3 more
doaj   +1 more source

Tear fluid as a novel specimen for detection of alpha-synuclein seeding activity in Parkinson’s disease

Scientific Reports
Parkinson’s disease (PD) is a clinically heterogeneous neurodegenerative disorder characterized by intraneuronal accumulation of misfolded α-synuclein.
Matteo Costanzo, Anna Ladogana, Marco Sbriccoli, Francesco Marchet, Flavia Porreca, Clara Salciccia, Michele Equestre, Gabriele Moracci, Maria Ilenia De Bartolo, Giulia Ruocco, Filippo Carlo Carlà, Antonella Conte, Giovanni Fabbrini, Daniele Belvisi, Anna Poleggi   +14 more
doaj   +1 more source

RT-QuIC Reactivity in the Brain and Other Organs and Tissues in Early, Middle-early, Middle-late and Terminal Stages of Scrapie Agent 263K Intracerebral Infection in Hamsters

Zoonoses
Objective: This study was aimed at analyzing the distribution and progression of prion seeds across the central nervous system (CNS) and peripheral tissues, by evaluating ...
Donglin Liang, Chumou Liu, Kang Xiao, Yuan Wang, Donghua Zhou, Xiaoxi Jia, Yuezhang Wu, Xiaoping Dong, Qi Shi   +8 more
doaj   +1 more source

Issue Information

Brain Pathology, Volume 36, Issue 3, May 2026.
wiley   +1 more source