Results 41 to 50 of about 616,892 (193)

Characterisation of RT-QuIC negative cases from the UK National CJD Research and Surveillance programme. [PDF]

J Neurol
Introduction Incorporation of the real-time quaking-induced conversion (RT-QuIC) assays for diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) has transformed diagnosis largely related to its extremely high specificity.
Ng D, Watson N, McDermott EA, Kurucu H, Summers D, Andrews M, Green A, Barria M, McKenzie J, Tam J, Smith C, Pal S.   +11 more
europepmc   +2 more sources

Early detection of abnormal prion protein in genetic human prion diseases now possible using real-time QUIC assay. [PDF]

PLoS ONE, 2013
INTRODUCTION: The definitive diagnosis of genetic prion diseases (gPrD) requires pathological confirmation. To date, diagnosis has relied upon the finding of the biomarkers 14-3-3 protein and total tau (t-tau) protein in the cerebrospinal fluid (CSF ...
Kazunori Sano, Katsuya Satoh, Ryuichiro Atarashi, Hiroshi Takashima, Yasushi Iwasaki, Mari Yoshida, Nobuo Sanjo, Hiroyuki Murai, Hidehiro Mizusawa, Matthias Schmitz, Inga Zerr, Yong-Sun Kim, Noriyuki Nishida   +12 more
doaj   +6 more sources

RT-QuIC detection of chronic wasting disease prion in platelet samples of white-tailed deer. [PDF]

BMC Vet Res
Background Chronic wasting disease (CWD) is a prion disease of captive and free-ranging cervids. Currently, a definitive diagnosis of CWD relies on immunohistochemistry detection of PrP^Sc in the obex and retropharyngeal lymph node (RPLN) of the affected
Kobashigawa E, Russell S, Zhang MZ, Sinnott EA, Connolly M, Zhang S.   +5 more
europepmc   +2 more sources

Comparative study of immunoassays, a microelectromechanical systems-based biosensor, and RT-QuIC for the diagnosis of chronic wasting disease in white-tailed deer. [PDF]

BMC Vet Res
Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy in cervids. The disease is caused by a pathogenic prion, namely PrPSc.
Kobashigawa E, Muhsin SA, Abdullah A, Allen K, Sinnott EA, Zhang MZ, Russell S, Almasri M, Zhang S.   +8 more
europepmc   +2 more sources

Correction: RT-QuIC: a highly promising diagnostic method for neurodegenerative diseases-advantages and limitations. [PDF]

Front Neurol
[This corrects the article DOI: 10.3389/fneur.2025.1578252.].
Koníčková D, Hraboš D, Menšíková K, Tučková L, Kaleta M, Strnad M, Colosimo C, Kaňovský P.   +7 more
europepmc   +2 more sources

Biochemical signatures of skin α-synuclein in synucleinopathies revealed by RT-QuIC assay end-product analysis. [PDF]

Acta Neuropathol
Synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), share pathological accumulation of misfolded α-synuclein (αSyn) in the brain and overlapping clinical features, complicating ...
Gerasimenko M, Yi H, Gilliland T, Chen Y, Wang Z, Zou WQ.   +5 more
europepmc   +2 more sources

A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases [PDF]

Acta Neuropathologica Communications, 2020
Multiple neurodegenerative diseases are characterized by aggregation of tau molecules. Adult humans express six isoforms of tau that contain either 3 or 4 microtubule binding repeats (3R or 4R tau).
Michael A. Metrick, Natália do Carmo Ferreira, Eri Saijo, Allison Kraus, Kathy Newell, Gianluigi Zanusso, Michele Vendruscolo, Bernardino Ghetti, Byron Caughey   +8 more
doaj   +8 more sources

Inter-laboratory comparison of real-time quaking-induced conversion (RT-QuIC) for the detection of chronic wasting disease prions in white-tailed deer retropharyngeal lymph nodes. [PDF]

J Vet Diagn Invest
The rapid geographic spread of chronic wasting disease (CWD) in white-tailed deer (WTD; Odocoileus virginianus) increases the need for the development and validation of new detection tests.
Darish JR, Kaganer AW, Hanley BJ, Schuler KL, Schwabenlander MD, Wolf TM, Ahmed MS, Rowden GR, Larsen PA, Kobashigawa E, Tewari D, Lichtenberg S, Pedersen JA, Zhang S, Sreevatsan S.   +14 more
europepmc   +2 more sources

Determination of prion proteins in the diagnosis of Creutzfeldt-Jakob disease using RT-QuIC: A case report from northeastern Colombia [PDF]

Biomedica
Creutzfeldt-Jakob disease is a rare neurodegenerative disease caused by prions. We present the case of a woman in the seventh decade of life with rapidly progressive dementia and myoclonus.
Lizarazo J, Vargas AX, Olarte R, Lizarazo DA.   +3 more
europepmc   +2 more sources

Detection of CWD in cervids by RT-QuIC assay of third eyelids.

PLoS ONE, 2019
The diagnosis of chronic wasting disease (CWD) relies on demonstration of the disease-associated misfolded CWD prion protein (PrPCWD) in brain or retropharyngeal lymph node tissue by immunodetection methods, e.g. ELISA and immunohistochemistry (IHC). The
Sarah K Cooper, Clare E Hoover, Davin M Henderson, Nicholas J Haley, Candace K Mathiason, Edward A Hoover   +5 more
doaj   +3 more sources