Results 21 to 30 of about 424,860 (186)

Detection and diagnosis of prion diseases using RT-QuIC: an update

, 2017
Until recently, it has been difficult to detect all infectious levels of prions and diagnose prion diseases in living humans and other animals. Real-time quaking-induced conversion (RT-QuIC), an ultrasensitive test based on amplification of the amyloid ...
Michele Fiorini, Byron Caughey, Maurizio Pocchiari, Raymond, Gregory J., Christina D. Orru, Matteo Manca, Andrew G. Hughson, Lynne D. Raymond, Caughey, Byron, Kraus, Allison, Matilde Bongianni, Gregory J. Raymond, Gianluigi Zanusso, Pocchiari, Maurizio, Zanusso, Gianluigi, Allison Kraus, Groveman, Bradley R., Bongianni, Matilde, Manca, Matteo, Fiorini, Michele, Orru, Christina D., Bradley R. Groveman, Hughson, Andrew G., Raymond, Lynne D.   +23 more
core   +2 more sources

High diagnostic accuracy of RT-QuIC assay in a prospective study of patients with suspected sCJD [PDF]

International Journal of Molecular Sciences, 2020
The early and accurate in vivo diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) is essential in order to differentiate CJD from treatable rapidly progressive dementias. Diagnostic investigations supportive of clinical CJD diagnosis include magnetic
Michele Fiorini, Daniela Perra, Silvia Testi, Monaco, Salvatore, Stefano Capaldi, Testi, Silvia, Sarah Vascellari, Luca Sacchetto, Capaldi, Stefano, Matilde Bongianni, Iselle, Giorgia, Gianluigi Zanusso, Zanusso, Gianluigi, Sergio Ferrari, Salvatore Monaco, Bongianni, Matilde, Fiorini, Michele, Vascellari, Sarah, Sacchetto, Luca, Ferrari, Sergio, Mombello, Aldo, Giorgia Iselle, Aldo Mombello, Perra, Daniela   +23 more
core   +4 more sources

α‐Synuclein RT‐QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies [PDF]

Annals of Clinical and Translational Neurology, 2019
We applied RT‐QuIC assay to detect α‐synuclein aggregates in cerebrospinal fluid (CSF) of patients with suspected Creutzfeldt–Jakob disease who had a neuropathological diagnosis of dementia with Lewy bodies (DLB) (n = 7), other neurodegenerative diseases
Matilde Bongianni, Anna Ladogana, Stefano Capaldi, Sigrid Klotz, Simone Baiardi, Annachiara Cagnin, Daniela Perra, Michele Fiorini, Anna Poleggi, Giuseppe Legname, Tatiana Cattaruzza, Francesco Janes, Massimo Tabaton, Bernardino Ghetti, Salvatore Monaco, Gabor G. Kovacs, Piero Parchi, Maurizio Pocchiari, Gianluigi Zanusso   +18 more
doaj   +6 more sources

Application of α-Syn Real-Time Quaking-Induced Conversion for Brain and Skin Specimens of the Chinese Patients With Parkinson’s Disease

Frontiers in Aging Neuroscience, 2022
The real-time quaking-induced conversion (RT-QuIC) assay has been developed and used as an in vitro diagnostic tool for Parkinson’s disease (PD). In this study, we established α-Syn RT-QuIC using recombinant human α-Syn as the substrate.
Dong-Dong Chen, Ling Jiao, Yue Huang, Kang Xiao, Li-Ping Gao, Cao Chen, Cao Chen, Qi Shi, Qi Shi, Xiao-Ping Dong, Xiao-Ping Dong, Xiao-Ping Dong, Xiao-Ping Dong   +12 more
doaj   +1 more source

Prion Seeding Activity in Plant Tissues Detected by RT-QuIC. [PDF]

Pathogens
Prion diseases such as scrapie, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) affect domesticated and wild herbivorous mammals. Animals afflicted with CWD, the transmissible spongiform encephalopathy of cervids (deer, elk, and moose), shed prions into the environment, where they may persist and remain infectious for years ...
Burgener K, Lichtenberg SS, Walsh DP, Inzalaco HN, Lomax A, Pedersen JA.   +5 more
europepmc   +4 more sources

HTTP/2 and QUIC for virtual worlds and the 3D Web? [PDF]

, 2015
The continuing advances in computer graphics and Internet bandwidths are supporting a gradual convergence between multi-user virtual worlds (MUVW), such as Second Life and OpenSim (SL/OS), and the nascent 3D Web.
Miller, Alan Henry David, Bakri, Hussein, Allison, Colin, Oliver, Iain, Oliver, Iain Angus, Miller, Alan   +5 more
core   +3 more sources

Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies

Acta Neuropathologica Communications, 2021
Definitive diagnosis of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) relies on postmortem finding of disease-associated alpha-synuclein (αSynD) as misfolded protein aggregates in the central nervous system (CNS). The recent development of
Connor Bargar, Wen Wang, Steven A. Gunzler, Alexandra LeFevre, Zerui Wang, Alan J. Lerner, Neena Singh, Curtis Tatsuoka, Brian Appleby, Xiongwei Zhu, Rong Xu, Vahram Haroutunian, Wen-Quan Zou, Jiyan Ma, Shu G. Chen   +14 more
doaj   +1 more source

RT-QuIC: a highly promising diagnostic method for neurodegenerative diseases-advantages and limitations. [PDF]

Front Neurol
Although it has been more than 200 years since Parkinson’s disease was described, we have not established biomarkers for its definitive diagnosis yet. Moreover, there is a similar case for the entire group of α-synucleinopathies, which are all characterized by the pathological accumulation of aggregated α-synuclein (α-Syn) in the brain and other ...
Koníčková D, Hraboš D, Menšíková K, Tučková L, Kaleta M, Strnad M, Colosimo C, Kaňovský P.   +7 more
europepmc   +6 more sources

Detekce prionových kmenů pomocí metody RT-QuIC [PDF]

Prionová onemocnění jsou skupinou progresivních, smrtelných neurodegenerativních poruch, které každoročně postihují přibližně 1-2 osoby na milion. Vzhledem ke své přenosné povaze a odolnosti vůči vlivům prostředí představují významné riziko pro veřejné ...
Chepizhko, Veronika
core   +2 more sources

THE DIAGNOSTIC UTILITY OF RT-QUIC IN SPORADIC CJD [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2014
Sporadic CJD (sCJD) remains the commonest type of CJD. Currently, there is not a disease specific antemortem test available for the diagnosis of sCJD with postmortem remaining the definitive method of diagnosis. Current diagnostic criteria rely on clinical presentation in association with the MRI, EEG and CSF 14–3–3 protein.
Louise Davidson, Alison Green, Lynne McGuire, Robert G Will, Richard Knight   +4 more
openaire   +1 more source