Results 121 to 130 of about 616,892 (193)
Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 122-130, January 2026.Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo +13 more
wiley +1 more source
Seed amplification and neurodegeneration marker trajectories in individuals at risk of prion disease [PDF]
, 2023 Human prion diseases are remarkable for long incubation times followed typically by rapid clinical decline. Seed amplification assays and neurodegeneration biofluid biomarkers are remarkably useful in the clinical phase, but their potential to predict ...
Batchelor, Mark +32 more
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Alpha‐synuclein quantitative seed amplification assay predicts conversion to dementia
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION The alpha‐synuclein seed amplification assay (SAA) has shown excellent performance in the detection of Lewy body pathology in cerebrospinal fluid (CSF). Lewy body pathology is prognostically relevant in patients at risk for dementia. Current assays only provide binary results, so there is a need to quantify the extent of pathology
Stefan Bräuer +37 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.Plasma biomarkers in CJD reveal multisystem involvement, with neuronal injury markers showing strong discriminative performance and vascular proteins indicating blood–brain barrier dysfunction. In asymptomatic PRNP mutation carriers, biomarker changes are minimal and emerge mainly near disease onset ABSTRACT Background Plasma markers of neuronal injury
Zhong‐Yun Chen +11 more
wiley +1 more source
α‐Synuclein RT‐QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies
Annals of Clinical and Translational Neurology, 2019 We applied RT‐QuIC assay to detect α‐synuclein aggregates in cerebrospinal fluid (CSF) of patients with suspected Creutzfeldt–Jakob disease who had a neuropathological diagnosis of dementia with Lewy bodies (DLB) (n = 7), other neurodegenerative diseases
Matilde Bongianni +18 more
doaj +1 more source
Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies
Experimental Gerontologysynucleinopathies are diseases characterized by the aggregation of α-synuclein (α-syn), which forms fibrils through misfolding and accumulates in a prion-like manner.
Juan Huang +6 more
doaj +1 more source
Improving protocols for α-synuclein seed amplification assays: analysis of preanalytical and analytical variables and identification of candidate parameters for seed quantification [PDF]
Objectives: The effect of preanalytical and analytical factors on the α-synuclein (α-syn) seed amplification assay's (SAA) performance has not been fully explored.
Baiardi, Simone +8 more
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Movement Disorders Clinical Practice, Volume 13, Issue 3, Page 832-834, March 2026.
Lukas Gattermeyer‐Kell +6 more
wiley +1 more source
Prion Epidemiology And The Npdpsc’s Experience With Rt-Quic [PDF]
, 2019 Prion diseases, or transmissible spongiform encephalopathies, constitute a wide array of invariably fatal rapidly progressive neurodegenerative illnesses that affect both humans and animals.
Wrona, Aleksandra
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BMC Research NotesObjective The goal of the research presented here is to determine if methods previously developed for the aqueous extraction of PrPSc from formalin-fixed paraffin-embedded tissue (FFPET) are applicable to the detection PrPSc by real-time quaking induced ...
Eric M. Nicholson +2 more
doaj +1 more source