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α-Synuclein Seeding Assay Using RT-QuIC
2021Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of α-synuclein (αSyn). They include Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. In each disease, it has been proposed that aggregates of αSyn represent different conformational strains of αSyn, leading to self ...
Ayami, Okuzumi +6 more
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This study quantified the occurrence of an underlying synucleinopathy in 50 patients with idiopathic normal pressure hydrocephalus by means of real‐time quaking‐induced conversion, a highly sensitive and specific technique capable of detecting and amplifying misfolded aggregated forms of α‐synuclein in the cerebrospinal fluid.
Alfonso Fasano +14 more
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RT-QuIC Assays for Prion Disease Detection and Diagnostics
2017In coping with prion diseases, it is important to have tests that are practical enough for routine applications in medicine, agriculture, wildlife biology, and research, yet sensitive enough to detect minimal amounts of infectivity. Real-time quaking-induced conversion (RT-QuIC) assays have evolved to the point where they fulfill these criteria in ...
Christina D, Orrù +9 more
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Seed amplification and RT-QuIC assays to investigate protein seed structures and strains
Cell and Tissue Research, 2022The accumulation of misfolded proteins as amyloid fibrils in the brain is characteristic of most neurodegenerative disorders. These misfolded proteins are capable of self-amplifying through protein seeding mechanisms, leading to accumulation in the host. First shown for PrP prions and prion diseases, it is now recognized that self-propagating misfolded
Heidi G. Standke, Allison Kraus
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Tracking Prions by RT-QuIC: An Update
Prion seed amplification assays, such as real-time quaking-induced conversion (RT-QuIC), are providing ultrasensitive, specific, and increasingly practical means of detecting prions and diagnosing prion diseases in humans and other animals. Widespread efforts have greatly increased the breadth of RT-QuIC applications for research, surveillance, and ...Christina D, Orrù +2 more
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Acta Neurologica Belgica, 2018
Sporadic Creutzfeldt-Jakob disease (sCJD) is a human prion disease that is a relatively common differential diagnosis in dementia patients. Therefore it needs a good diagnostic tool. Brain autopsy is the golden standard for the diagnosis of CJD; however, a less invasive technique is 14-3-3 protein measurement in the cerebrospinal fluid (CSF).
Olivia Behaeghe +3 more
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Sporadic Creutzfeldt-Jakob disease (sCJD) is a human prion disease that is a relatively common differential diagnosis in dementia patients. Therefore it needs a good diagnostic tool. Brain autopsy is the golden standard for the diagnosis of CJD; however, a less invasive technique is 14-3-3 protein measurement in the cerebrospinal fluid (CSF).
Olivia Behaeghe +3 more
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Advancing Prion Diagnostics: RT-QuIC Applications in Peripheral Tissues
Prion diseases (PrDs) are fatal neurodegenerative disorders characterized by the accumulation of misfolded prion protein (PrPSc) in the central nervous system (CNS). This pathological isoform of the cellular prion protein drives disease pathogenesis through its unique ability to propagate itself via a template-directed misfolding mechanism.Bacınoglu, Merve Begum +5 more
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Three-Way Clustering of RT-QuIC for Prion Disease Diagnosis
Prion diseases, such as Creutzfeldt–Jakob disease (CJD), are rare, invariably fatal, and rapidly progressive neurodegenerative disorders caused by the accumulation of misfolded prion protein (PrPSc) in the central nervous system. Their diagnosis is challenging due to clinical heterogeneity and symptom overlap with other neurological conditions ...Gabriele D’Andrea +3 more
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The effect of terrain-influenced winds on fire spread in QUIC-Fire
Environmental Modelling and Software, 2023Rodman R. Linn +2 more
exaly
CSF RT-QuIC and the Diagnosis of Creutzfeldt–Jakob Disease
2021Alison J. E. Green, Neil I. McKenzie
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