Genomic Runs of Homozygosity Record Population History and Consanguinity [PDF]
PLoS ONE, 2010 The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is determined partly by the number of generations since the common ancestor: offspring of cousin ...
Harry Campbell, James G Wilson
exaly +12 more sources
Runs of Homozygosity Preliminary Investigation in Pig Breeds [PDF]
AnimalsRuns of homozygosity (ROH) are contiguous homozygous genomic segments that provide valuable insights into population history, selection pressures, and inbreeding levels. However, the global distribution of ROH and their implications for pig domestication
Yuqiang Liu +6 more
doaj +4 more sources
Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. [PDF]
PLoS Genetics, 2012 Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among ...
Matthew C Keller +10 more
doaj +14 more sources
Analysis of Runs of Homozygosity in Aberdeen Angus Cattle [PDF]
AnimalsA large number of cattle breeds have marked phenotypic differences. They are valuable models for studying genome evolution. ROH analysis can facilitate the discovery of genomic regions that may explain phenotypic differences between breeds affecting ...
Vladimir Kolpakov +3 more
doaj +4 more sources
Runs of homozygosity do not influence survival to old age. [PDF]
PLoS ONE, 2011 Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making
Maris Kuningas +6 more
doaj +14 more sources
Genomic Inbreeding and Runs of Homozygosity Analysis of Cashmere Goat [PDF]
AnimalsCashmere goats are valuable genetic resources which are famous worldwide for their high-quality fiber. Runs of homozygosity (ROHs) have been identified as an efficient tool to assess inbreeding level and identify related genes under selection.
Qian Zhao +11 more
doaj +4 more sources
Genomic inbreeding estimation in small populations: evaluation of runs of homozygosity in three local dairy cattle breeds [PDF]
Animal, 2016 In the local breeds with small population size, one of the most important problems is the increase of inbreeding coefficient (F). High levels of inbreeding lead to reduced genetic diversity and inbreeding depression.
S. Mastrangelo +5 more
doaj +4 more sources
Genome-wide scan for runs of homozygosity in South American Camelids [PDF]
BMC Genomics, 2023 Background Alpaca (Vicugna pacos), llama (Lama glama), vicugna (Vicugna vicugna) and guanaco (Lama guanicoe), are the camelid species distributed over the Andean high-altitude grasslands, the Altiplano, and the Patagonian arid steppes.
Stefano Pallotti +4 more
doaj +2 more sources
Runs of homozygosity and selection signature analyses reveal putative genomic regions for artificial selection in layer breeding [PDF]
BMC GenomicsBackground The breeding of layers emphasizes the continual selection of egg-related traits, such as egg production, egg quality and eggshell, which enhance their productivity and meet the demand of market.
Xiaochang Li +7 more
doaj +2 more sources
Detection of Runs of Homozygosity and Identification of Candidate Genes in the Whole Genome of Tunchang Pigs [PDF]
AnimalsTunchang pigs are an indigenous pig population in China known for their high tolerance to roughage, delicious meat, and fecundity. However, the number of Tunchang pigs has been declining due to the influence of commercial breeds and African swine fever ...
Ziyi Wang +8 more
doaj +2 more sources