Results 11 to 20 of about 15,343 (276)

Runs of homozygosity and population history in cattle [PDF]

BMC Genetics, 2012
Background Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring.
Purfield Deirdre C, Berry Donagh P, McParland Sinead, Bradley Daniel G   +3 more
doaj   +6 more sources

Long runs of homozygosity are associated with Alzheimer’s disease [PDF]

Translational Psychiatry, 2021
Long runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of inbreeding and recessive inheritance. The presence of recessive loci is suggested for Alzheimer’s disease (AD); however, their search has been ...
Sonia Moreno-Grau, Maria Victoria Fernández, Itziar de Rojas, Pablo Garcia-González, Isabel Hernández, Fabiana Farias, John P. Budde, Inés Quintela, Laura Madrid, Antonio González-Pérez, Laura Montrreal, Emilio Alarcón-Martín, Montserrat Alegret, Olalla Maroñas, Juan Antonio Pineda, Juan Macías, The GR@ACE study group, DEGESCO consortium, Marta Marquié, Sergi Valero, Alba Benaque, Jordi Clarimón, Maria Jesus Bullido, Guillermo García-Ribas, Pau Pástor, Pascual Sánchez-Juan, Victoria Álvarez, Gerard Piñol-Ripoll, Jose María García-Alberca, José Luis Royo, Emilio Franco-Macías, Pablo Mir, Miguel Calero, Miguel Medina, Alberto Rábano, Jesús Ávila, Carmen Antúnez, Luis Miguel Real, Adelina Orellana, Ángel Carracedo, María Eugenia Sáez, Lluís Tárraga, Mercè Boada, Carlos Cruchaga, Agustín Ruiz, for the Alzheimer’s Disease Neuroimaging Initiative   +45 more
doaj   +16 more sources

Genome-wide analysis of runs of homozygosity in Italian Mediterranean buffalo

Journal of Dairy Science, 2022
: Runs of homozygosity (ROH) are a powerful tool to explore patterns of genomic inbreeding in animal populations and detect signatures of selection. The present study used ROH analysis to evaluate the genome-wide patterns of homozygosity, inbreeding ...
Shen-he Liu, Xiao-ya Ma, Faiz-ul Hassan, Teng-yun Gao, Ting-xian Deng   +4 more
doaj   +3 more sources

GENOMIC VARIABILITY AMONG CATTLE POPULATIONS BASED ON RUNS OF HOMOZYGOSITY [PDF]

Poljoprivreda, 2015
In this work, the distribution of different lengths ROH (runs of homozygosity) in six cattle breeds was described. A total of 122 animals from six cattle breeds (Holstein, Simmental, Austrian Pinzgau, Ayrshire, MRI-Meuse Rhine Issel and Slovak Pinzgau ...
Veronika Šidlová, Radovan Kasarda, Nina Moravčíková, Anna Trakovická , Ino Curik, Maja Ferenčaković   +5 more
doaj   +3 more sources

Runs of Homozygosity in Modern Chicken Revealed by Sequence Data

G3: Genes, Genomes, Genetics, 2020
Runs of homozygosity (ROH) are chromosomal stretches that in a diploid genome appear in a homozygous state and display identical alleles at multiple contiguous loci.
Reza Talebi, Tomasz Szmatoła, Gábor Mészáros, Saber Qanbari   +3 more
doaj   +3 more sources

Runs of Homozygosity and Inferences in Wild Populations. [PDF]

Mol Ecol
ABSTRACTLong homozygous chromosome segments are known as runs of homozygosity (ROH); these reflect patterns of identity by descent and can be used to measure individual inbreeding, map recessive traits, and reconstruct demographic histories. Here, we review some key considerations with ROH detection and the inferences pertaining to inbreeding and ...
Shafer ABA, Kardos M.
europepmc   +3 more sources

Runs of Homozygosity in European Populations [PDF]

The American Journal of Human Genetics, 2008
Estimating individual genome-wide autozygosity is important both in the identification of recessive disease variants via homozygosity mapping and in the investigation of the effects of genome-wide homozygosity on traits of biomedical importance. Approaches have tended to involve either single-point estimates or rather complex multipoint methods of ...
McQuillan, Ruth, Leutenegger, Anne-Louise, Abdel-Rahman, Rehab, Franklin, Christopher S, Pericic, Marijana, Barac-Lauc, Lovorka, Smolej-Narancic, Nina, Janicijevic, Branka, Polasek, Ozren, Tenesa, Albert, Macleod, Andrew K, Farrington, Susan M, Rudan, Pavao, Hayward, Caroline, Vitart, Veronique, Rudan, Igor, Wild, Sarah H, Dunlop, Malcolm G, Wright, Alan F, Campbell, Harry, Wilson, James F   +20 more
  +9 more sources

Runs of homozygosity and analysis of inbreeding depression [PDF]

Journal of Animal Science, 2020
Abstract Pedigree information was traditionally used to assess inbreeding. The availability of high-density marker panels provides an alternative to assess inbreeding, particularly in the presence of incomplete and error-prone pedigrees.
Pattarapol Sumreddee, Sajjad Toghiani, El Hamidi Hay, Andrew Roberts, Samuel E Aggrey, Romdhane Rekaya   +5 more
openaire   +3 more sources

Ethnic Identity and Genome Wide Runs of Homozygosity [PDF]

Behavior Genetics, 2021
AbstractIt is long known that inbreeding increases the detrimental effects of recessive sequence variants in “Runs of Homozygosity” (ROHs). However, although the phenotypic association of ROH has been investigated for a variety of traits, the statistical power of the results often remains limited as a sufficiently high number of cases are available for
Fieder, Martin, Mitchell, Brittany L., Gordon, Scott, Huber, Susanne, Martin, Nicholas G.   +4 more
openaire   +5 more sources

Facial attractiveness is only weakly linked to genome–wide heterozygosity

Frontiers in Psychology, 2023
IntroductionIt has been frequently suggested that overall genomic heterozygosity and, particularly, heterozygosity of loci on the so-called major histocompatibility complex (MHC), which is responsible for the recognition of foreign substances/ pathogens ...
Martin Fieder, Martin Fieder, Susanne Huber   +2 more
doaj   +1 more source