Results 201 to 210 of about 27,021 (267)

Accelerating real‐world prediction and research in Alzheimer's: The M3AD study

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Chronic diseases, including Alzheimer's disease (AD) and related dementia (ADRD), do not exist solely as isolated entities. Instead, they weave concomitant trajectories of multiple diseases, conditions, behaviors, and risks, mutually influencing each other's course and natural history, in ways yet unexplored.
Moïse Desvarieux, Tatjana Rundek, Habibul Ahsan, Javier Narvaez, Felipe Diaz, Daniel Malinsky, Luis Marco Ruiz, Maxim Topaz, Thomas Falconer, Karthik Natarajan, James Noble, Barbara Entwisle, Deepthi Puram, Tara Anand, Hsin Yi Chen, Xinzhuo Jiang, Yian Gu, Alan Cohen, Mary Beth Terry, Brandon Pierce, Howard Andrews, Emily Rogalsky, Shahla Farzana, George Gulotta, John Beard, Danielle Landron, Samuel L Volchenboum, Philippe Ravaud, Julie Johnson, Ezra Susser, Andrew Rundle, Ying Wei, Nick Tsinoremas, David Loewenstein, Linda Fried, Allison Aiello, Richard Mayeux, George Hripcsak   +37 more
wiley   +1 more source

Innovating HTA: a call for capacity building and standardization. [PDF]

Int J Technol Assess Health Care
Delnoij DMJ, Dawoud DM, Elvidge J, Kaló Z, Knies S, Németh B, Goettsch W.   +6 more
europepmc   +1 more source

Key Stakeholders' Knowledge, Opinions, and Interests on Real-World Evidence in the Regulatory Process-Results of an EU-Wide Survey. [PDF]

Clin Transl Sci
Depner FL, Russek M, Röthlein C, Becker C, Peltner J, Pfeifer K, Reviers E, De Valck D, Wicherski J, Hartikainen S, Tolppanen AM, Haenisch B.   +11 more
europepmc   +1 more source

Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4‐ and VEGF‐mediated pathways: insights from a vascular to mixed‐type dementia model

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Chronic cerebral hypoperfusion (CCH) is a major contributor to cognitive impairment; however, its underlying mechanisms remain poorly understood. METHODS We investigated CCH‐induced glymphatic dysfunction and neurodegeneration in amyloid precursor protein (APP)/presenilin 1 (PS1) and wild‐type mice.
Jia‐Hung Chen, Ching‐Wen Chang, You‐Yin Chen, Chih‐Hao Yang, Wen‐Bin Yang, Yi‐Chen Hsieh, Yao‐Wen Liang, Ssu‐Ju Li, Chaur‐Jong Hu   +8 more
wiley   +1 more source

Ensuring Reliability of Curated Electronic Health Record-Derived Data: The Validation of Accuracy for Large Language Model-/Machine Learning-Extracted Information and Data (VALID) Framework. [PDF]

JCO Clin Cancer Inform
Estevez M, Singh N, Dyson L, Adamson B, Krismer K, Magee K, Yuan Q, Hildner MW, Fidyk E, Williams T, Mbah O, Khan F, Seidl-Rathkopf K, Cohen AB.   +13 more
europepmc   +1 more source

Impact of Thiazides and Fluoropyrimidines Interaction on Myelotoxicity and Other Adverse Events in Real‐World Practice: A Retrospective Cohort Study

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Introduction The European Summary of Product Characteristics (SmPC) for 5‐FU warns of significant granulocyte decline when combined with thiazides, cyclophosphamide, or methotrexate, based on a 1981 cohort of 14 patients. Despite limited evidence, drug‐interaction checkers still flag this risk.
Gerard Ronda‐Roca, José Porcel‐Maleno, Mónica Lobo‐Palomar, Gustavo Centeno‐Soto, Ana Ruiz‐Casado, Belén Ruiz‐Antorán   +5 more
wiley   +1 more source

Systematic Review of Genomic‐Based Risk Stratification in Localised Prostate Cancer Treatment Optimisation: Clinical Impact and Health Economic Evidence

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Several genomic risk stratification tests are available to predict the risk of metastasis and mortality for prostate cancer patients at the time of diagnosis. However, the evidence supporting the clinical utility of genomic risk stratification tools is fragmented, posing challenges in assessing their real‐world clinical impact and ...
Juntao Lyu, Fan He, Niall M. Corcoran, Gang Chen, Hadi Akbarzadeh Khorshidi   +4 more
wiley   +1 more source

MCC‐135 Exerts Antiepileptic and Neuroprotective Effects by Downregulating NCX1 Expression to Decrease Intracellular Calcium Overload in the Hippocampus

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
MCC‐135 treatment significantly prolonged the seizure latency and alleviated hippocampal neuronal damage in KA‐induced epileptic mice. Furthermore, MCC‐135 reduced NCX1 levels, alleviated intracellular calcium overload, and downregulated glutamate levels in the epileptic mice.
Chaoning Liu, Min He, Rida Li, Shouhuan Zheng, Lanfeng Sun, Chi Gong, Hengchang Qi, Xinran Qin, Xiaohang Gan, Fang Wang, Yuan Wu   +10 more
wiley   +1 more source

ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
ALKBH3 alleviates myocardial ischemia/reperfusion injury by suppressing PANoptosis. ALKBH3 promotes ZBED6 translation via mRNA m1A demethylation. ZBED6 promotes the interaction between STAT1 and NEDD4L to facilitate STAT1 ubiquitination and subsequent degradation.
Hongtao Diao, Chunlei Wang, Yuting Xiong, Qiaoyue Zhao, Xinyue Zhang, Xiaohui Qi, Yuan Zou, Jiaxuan Li, Linghua Zeng, Wei Si, Feng Zhang, Ping Pang, Ning Wang, Yu Bian, Baofeng Yang   +14 more
wiley   +1 more source