Results 1 to 10 of about 2,365,951 (330)

Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders [PDF]

Nature Communications
Heart failure, the leading cause of mortality and morbidity in the developed world, is characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated, oxidized, and depleted of the stabilizing subunit calstabin-2.
Marco C. Miotto, Steven Reiken, Anetta Wronska, Qi Yuan, Haikel Dridi, Yang Liu, Gunnar Weninger, Carl Tchagou, Andrew R. Marks   +8 more
doaj   +3 more sources

Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction

Brain Research Bulletin, 2023
Background: Postoperative cognitive dysfunction (POCD) is characterized by impaired learning and memory. 6 h duration isoflurane anesthesia is an important factor to induce POCD, and the dysfunction of ryanodine receptor (RyR) in the hippocampus may be ...
Binwen Liu, Xurui Zhu, Qingyun Zhou, Yan Su, Yue Qian, Zhengliang Ma, Xiaoping Gu, Tianjiao Xia   +7 more
doaj   +2 more sources

Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression [PDF]

Nature Communications
Ryanodine receptor 1 Ca2+ leak is a signal in skeletal muscle, but chronic leak can underlie pathology. Here we show that in healthy male mouse, limb-girdle muscle presents higher sympathetic input, elevated ryanodine receptor 1 basal phosphorylation ...
Aldo Meizoso-Huesca, Cedric R. Lamboley, James R. Krycer, Mark P. Hodson, James E. Hudson, Bradley S. Launikonis   +5 more
doaj   +2 more sources

Cryo-EM investigation of ryanodine receptor type 3 [PDF]

Nature Communications
Ryanodine Receptor isoform 3 (RyR3) is a large ion channel found in the endoplasmic reticulum membrane of many different cell types. Within the hippocampal region of the brain, it is found in dendritic spines and regulates synaptic plasticity.
Yu Seby Chen, Maricela Garcia-Castañeda, Maria Charalambous, Daniela Rossi, Vincenzo Sorrentino, Filip Van Petegem   +5 more
doaj   +2 more sources

Disparate molecular mechanisms in cardiac ryanodine receptor channelopathies [PDF]

Frontiers in Molecular Biosciences
AimsMutations in the cardiac ryanodine receptor (RyR2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). This study investigates the underlying molecular mechanisms for CPVT mutations within the RyR2 N-terminus domain (NTD)
Yadan Zhang, Monika Seidel, Camille Rabesahala de Meritens, Astrid Beckmann, Syeda Ahmed, Melanie Hurtz, F. Anthony Lai, Esther Zorio, Esther Zorio, Esther Zorio, Esther Zorio, Dimitris Parthimos, Spyros Zissimopoulos   +12 more
doaj   +2 more sources

Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol. [PDF]

J Gen Physiol, 2023
Scriven DRL, Johnsen AB, Asghari P, Chou KC, Moore EDW.   +4 more
europepmc   +3 more sources

Ryanodine receptors [PDF]

Skeletal Muscle, 2011
Abstract Excitation-contraction coupling involves the faithful conversion of electrical stimuli to mechanical shortening in striated muscle cells, enabled by the ubiquitous second messenger, calcium. Crucial to this process are ryanodine receptors (RyRs), the sentinels of massive intracellular calcium stores contained within the sarcoplasmic ...
Capes E Michelle, Loaiza Randall, Valdivia Héctor H   +2 more
openaire   +3 more sources

Calcium Homeostasis in Myogenic Differentiation Factor 1 (MyoD)-Transformed, Virally-Transduced, Skin-Derived Equine Myotubes [PDF]

, 2014
Dysfunctional skeletal muscle calcium homeostasis plays a central role in the pathophysiology of several human and animal skeletal muscle disorders, in particular, genetic disorders associated with ryanodine receptor 1 (RYR1) mutations, such as malignant
A Hovnanian, A Klein, A Margreth, Atsushi Asakura, C Drogemuller, Cesare M. Terracciano, CM Isgren, DR Laver, E Zvaritch, EC McKenzie, EC McKenzie, F Ghassemi, FL Cole, G Avila, G Cherednichenko, Georges Vassaux, GG Harrison, GL Walmsley, H Gissel, H Jungbluth, H Weintraub, H Zhou, H Zhou, H Zhou, HK DiMaio Knych, J Choi, J Fujii, J Garcia, J Huang, J Larsen, J Ma, J Tong, JM Eltit, JM Eltit, JM Healy, JM MacLeay, JR Lopez, JR Lopez, JR Mickelson, K Anderson, K Jurkat-Rott, KP Glahn, L Csernoch, L Lattanzi, LR Lentz, M Aleman, M Fernandez-Fuente, M Fernandez-Fuente, MA Denborough, Marta Fernandez-Fuente, MC Roberts, MG Larach, MH Court, MJ Hull, MM Upjohn, N Dlamini, N Tilgen, NC Voermans, NM Burton, Pilar Martin-Duque, PJ Lynch, PK Dranchak, R Yasin, RA Bannister, RA Bannister, Richard J. Piercy, S Ducreux, S Gyorke, S Hollingworth, Susan C. Brown, T Abe, T Yang, TB Rogers, TC He, TV McCarthy, X Zhao   +75 more
core   +11 more sources

Ryanodine Receptors Selectively Interact with L Type Calcium Channels in Mouse Taste Cells. [PDF]

PLoS ONE, 2013
INTRODUCTION:WE REPORTED THAT RYANODINE RECEPTORS ARE EXPRESSED IN TWO DIFFERENT TYPES OF MAMMALIAN PERIPHERAL TASTE RECEPTOR CELLS: Type II and Type III cells. Type II cells lack voltage-gated calcium channels (VGCCs) and chemical synapses.
Michelle R Rebello, Amanda B Maliphol, Kathryn F Medler   +2 more
doaj   +1 more source

A basal level of γ-linolenic acid depletes Ca2+ stores and induces endoplasmic reticulum and oxidative stresses to cause death of breast cancer BT-474 cells

Chinese Journal of Physiology, 2021
Gamma-linolenic acid (GLA), a natural fatty acid obtained from oils of various vegetables and seeds, has been demonstrated as an anticancer agent. In this work, we investigated the anticancer effects of GLA on breast cancer BT-474 cells.
Cing-Yu Chen, Cheng-Hsun Wu, King-Chuen Wu, Lian-Ru Shiao, Chin-Min Chuang, Yuk-Man Leung, Louis W C Chow   +6 more
doaj   +1 more source