Results 11 to 20 of about 2,365,951 (330)

AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor

Nature Communications, 2017
In this work the authors show that AIP (aryl hydrocarbon receptor-interacting protein), a gene frequently mutated in association with pituitary tumors, regulates neurotransmitter release by inhibiting calcium release from ryanodine receptors.
Bojun Chen, Ping Liu, Edward J. Hujber, Yan Li, Erik M. Jorgensen, Zhao-Wen Wang   +5 more
doaj   +2 more sources

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

Nature, 2014
The ryanodine receptors (RyRs) are high-conductance intracellular Ca2+ channels that play a pivotal role in the excitation–contraction coupling of skeletal and cardiac muscles.
Yan Zhen, Xiao‐chen Bai, Chuangye Yan, Jianping Wu, Zhangqiang Li, Tian Xie, Wei Peng, Chang-Cheng Yin, Xueming Li, Sjors H. W. Scheres, Yigong Shi, Nieng Yan   +11 more
openalex   +2 more sources

Cardiac ryanodine receptor calcium release deficiency syndrome

Science Translational Medicine, 2021
Clinical and basic studies shed light on the mechanism, diagnosis, and treatment of cardiac ryanodine receptor Ca2+ release deficiency syndrome. Calcium and cardiac arrhythmia Calcium signaling couples cardiac electrical excitation and contraction and is
Bo Sun, Jinjing Yao, Mingke Ni, Jinhong Wei, Xiaowei Zhong, Wenting Guo, Lin Zhang, Ruiwu Wang, D. Belke, Yong-Xiang Chen, K. Lieve, A. K. Broendberg, T. Roston, I. Blankoff, J. Kammeraad, Johannes C. von Alvensleben, J. Lazarte, Alexander Vallmitjana, Loryn J. Bohne, R. Rose, R. Benítez, L. Hove-Madsen, C. Napolitano, R. Hegele, M. Fill, S. Sanatani, A. Wilde, Jason D. Roberts, S. Priori, H. Jensen, S. Chen   +30 more
semanticscholar   +1 more source

Ryanodine Receptor Patents [PDF]

Recent Patents on Biotechnology, 2012
Research over the past two decades has implicated dysfunction of the ryanodine receptor (RyR), a Ca(2+) release channel on the sarcoplasmic reticulum (SR) required for excitation-contraction (EC) coupling, in the pathogenesis of cardiac and skeletal myopathies.
Alexander, Kushnir, Andrew R, Marks
openaire   +2 more sources

Ryanodine receptor channelopathies [PDF]

Pflügers Archiv - European Journal of Physiology, 2010
Ryanodine receptors (RyR) are intracellular Ca2+-permeable channels that provide the sarcoplasmic reticulum Ca2+ release required for skeletal and cardiac muscle contractions. RyR1 underlies skeletal muscle contraction, and RyR2 fulfills this role in cardiac muscle.
Matthew J, Betzenhauser, Andrew R, Marks
openaire   +2 more sources

Structural Insight Into Ryanodine Receptor Channelopathies

Frontiers in Pharmacology, 2022
The ryanodine receptors (RyRs) are large cation-selective ligand-gated channels that are expressed in the sarcoplasmic reticulum (SR) membrane. They mediate the controlled release of Ca2+ from SR and play an important role in many cellular processes. The
Hadiatullah Hadiatullah, Hadiatullah Hadiatullah, Zhao He, Zhao He, Zhiguang Yuchi, Zhiguang Yuchi   +5 more
doaj   +1 more source

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. [PDF]

, 2020
Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels ...
Bers, Donald M, Cornea, Razvan L, Janicek, Kevyn A, Launikonis, Bradley S, Rebbeck, Robyn T, Singh, Daniel P, Thomas, David D   +6 more
core   +2 more sources

Ryanodine Receptor Adaptation [PDF]

The Journal of General Physiology, 2000
In the heart, depolarization during the action potential activates voltage-dependent Ca2+ channels that mediate a small, localized Ca2+ influx (ICa). This small Ca2+ signal activates specialized Ca2+ release channels, the ryanodine receptors (RyRs), in the sarcoplasmic reticulum (SR).
M, Fill, A, Zahradníková, C A, Villalba-Galea, I, Zahradník, A L, Escobar, S, Györke   +5 more
openaire   +2 more sources

Single Amino Acid Changes in the Ryanodine Receptor in the Human Population Have Effects In Vivo on Caenorhabditis elegans Neuro-Muscular Function

Frontiers in Genetics, 2020
The ryanodine receptor mediates intracellular calcium ion release with excitation of nerve and muscle cells. Ryanodine receptor missense variants cause a number of myopathologies, such as malignant hyperthermia, and have been linked with various ...
Brittany Graham, Marie-Anne Shaw, Ian A. Hope   +2 more
doaj   +1 more source

Hippocampus anatomical structure and distribution of agrin proteoglycan and ryanodine receptor expression boost bird food caching behavior

The European Zoological Journal, 2021
Feeding habitats and behavior are connected with various environmental conditions and anatomical structures of the hippocampus, altogether with proteins expression level that may enhance their cognitive memory abilities.
I. M. Hamza, Y. M. Mobarak, H. S. Hafez
doaj   +1 more source