Results 31 to 40 of about 2,365,951 (330)
Regulation of Ryanodine Receptor–Mediated Ca2+ Release in Vas Deferens Smooth Muscle Cells
Journal of Pharmacological Sciences, 2009 .: Ca2+ release from intracellular store sites via the ryanodine receptor (RyR) and hormonal regulation by flutamide, an androgen-receptor (AR) antagonist, on it were examined in vas deferens (VD) smooth muscle cells (SMCs).
Akitoshi Ohno +3 more
doaj +1 more source
Structural and functional conservation of key domains in InsP3 and ryanodine receptors. [PDF]
, 2012 Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by ...
Ames, James B +10 more
core +1 more source
The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
Nature Communications, 2019 Ryanodine receptors (RyR) are ion channels responsible for the release of Ca2+ from the sarco/endoplasmic reticulum and play a crucial role in the precise control of Ca2+ concentration in the cytosol. The detailed permeation mechanism of Ca2+ through RyR
Aihua Zhang +3 more
semanticscholar +1 more source
G3: Genes, Genomes, Genetics, 2017 Delaying the decline in skeletal muscle function will be critical to better maintenance of an active lifestyle in old age. The skeletal muscle ryanodine receptor, the major intracellular membrane channel through which calcium ions pass to elicit muscle ...
Katie Nicoll Baines +4 more
doaj +1 more source
Ryanodine Receptor 1-Related Myopathies: Diagnostic and Therapeutic Approaches
Neurotherapeutics, 2018 Ryanodine receptor type 1-related myopathies (RYR1-RM) are the most common class of congenital myopathies. Historically, RYR1-RM classification and diagnosis have been guided by histopathologic findings on muscle biopsy.
Tokunbor A. Lawal, J. Todd, K. Meilleur
semanticscholar +1 more source
The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]
, 2017 The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro +8 more
core +1 more source
Mechanisms of modulation of brain microvascular endothelial cells function by thrombin. [PDF]
, 2017 Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis.
Abood, Mary E. +4 more
core +2 more sources
Frontiers in Physiology, 2018 Heart contraction vitally depends on tightly controlled intracellular Ca regulation. Because contraction is mainly driven by Ca released from the sarcoplasmic reticulum (SR), this organelle plays a particularly important role in Ca regulation.
R. Nikolaienko, E. Bovo, A. Zima
semanticscholar +1 more source
Nature Communications, 2022 Ryanodine receptor 2 (RyR2) is a Ca2+ release channel essential for cardiac excitation-contraction coupling. Here, the authors use structural and functional analysis to reveal RyR2 gating mechanism and its alterations by pathogenic mutations.
Takuya Kobayashi +8 more
doaj +1 more source
The structural basis of ryanodine receptor ion channel function
The Journal of General Physiology, 2017 Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic reticulum.
G. Meissner
semanticscholar +1 more source