FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses [PDF]
Journal of Lipid Research, 2022 The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically conserved cysteine residues.
Katrina Mekhail +13 more
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A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation [PDF]
Nat BiotechnolThe 23 human zinc finger Asp-His-His-Cys motif-containing (ZDHHC) S-acyltransferases catalyze long-chain S-acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in disease. Here
Cory A. Ocasio +15 more
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S-acylation of Ca2+ transport proteins: molecular basis and functional consequences [PDF]
Biochem Soc TransCalcium (Ca2+) regulates a multitude of cellular processes during fertilization and throughout adult life by acting as an intracellular messenger to control effector functions in excitable and non-excitable cells. Changes in intracellular Ca2+ levels are
Raphaël Néré +3 more
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S-acylation of a non-secreted peptide controls plant immunity via secreted-peptide signal activation [PDF]
EMBO RepSmall peptides modulate multiple processes in plant cells, but their regulation by post-translational modification remains unclear. ROT4 (ROTUNDIFOLIA4) belongs to a family of Arabidopsis non-secreted small peptides, but knowledge on its molecular ...
Wenliang Li +12 more
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An atlas of Arabidopsis protein S-Acylation reveals its widespread role in plant cell organisation and function [PDF]
Nat Plants, 2022 S-acylation is the addition of a fatty acid to a cysteine residue of a protein. While this modification may profoundly alter protein behaviour, its effects on the function of plant proteins remains poorly characterized, largely as a result of the lack of
Manoj Kumar, Paul Carr, Simon Turner
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S‐acylation of Ca2+ transport proteins in cancer [PDF]
Chronic Diseases and Translational MedicineAlterations in cellular calcium (Ca2+) signals have been causally associated with the development and progression of human cancers. Cellular Ca2+ signals are generated by channels, pumps, and exchangers that move Ca2+ ions across membranes and are ...
Sana Kouba, Nicolas Demaurex
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Arabidopsis protein S-acyl transferases positively mediate BR signaling through S-acylation of BSK1 [PDF]
Proc Natl Acad Sci U S ASignificance Brassinosteriods (BRs) are plant hormones mediating various developmental processes. BSK1 relays BR signaling by interacting with the BR receptor BRI1 and phosphorylating downstream targets.
Fei Liu +7 more
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Detection of Protein S-Acylation using Acyl-Resin Assisted Capture
Journal of Visualized Experiments, 2020 Protein S-acylation, also referred to as S-palmitoylation, is a reversible post-translational modification of cysteine residues with long-chain fatty acids via a labile thioester bond.
Ritika Tewari +3 more
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A palmitoyl transferase chemical genetic system to map ZDHHC-specific S-acylation
bioRxiv, 2023 The 23 human ZDHHC S-acyltransferases catalyze long-chain S-acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in disease.
Cory A. Ocasio +13 more
semanticscholar +2 more sources
S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy [PDF]
Mol Cell, 2023 Xue Huang +20 more
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