Results 131 to 140 of about 14,441 (168)

Evaluation of Vortioxetine on Global DNA Methylation in Maternal and Offspring Rats and In Silico Molecular Docking to Key Epigenetic Enzymes. [PDF]

Int J Mol Sci
Günay M, Hız-Çelikliyurt MM, Akkuş G, Korkmaz ŞA.   +3 more
europepmc   +1 more source

Marine Bacterium <i>Kordia algicida</i> Reshapes Plankton Microbiome and Induces Metabolomic Rewiring, Independent of Heatwave or Worst-Case Climate Scenarios. [PDF]

J Nat Prod
Vallet M, Staudinger M, Syhapanha KS, Meunier CL, Kirstein IV, Pohnert G.   +5 more
europepmc   +1 more source

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S-adenosylhomocysteine hydrolase, S-adenosylmethionine, S-adenosylhomocysteine: correlations with ribavirin induced anemia

Medical Hypotheses, 2004
Objective is to speculate on the ribavirin induced anemia by inhibiting S-adenosylhomocysteine (SAH)-hydrolase activity. The major toxicity associated with the use of ribavirin is hemolytic anemia. This adverse effect has been ascribed to the accumulation of ribavirin triphosphate in the erythrocyte, which interferes with erythrocyte function ...
Engin, Altintas, Orhan, Sezgin
openaire   +3 more sources

S-Adenosylmethionine, S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase variations during differentiation of Dictyostelium discoideum

Cell Differentiation, 1988
We have analyzed the level of substrate (AdoMet) and products (AdoHcy) of transmethylations throughout the developmental cycle of the primitive eukaryote Dictyostelium discoideum. The ratio AdoMet/AdoHcy varied dramatically during differentiation. The intracellular level of AdoHcy decreased sharply after the beginning of starvation reaching a value of ...
M C, Guitton, B T, Keller, D, Part, J, De Gunzburg, R T, Borchardt, M, Véron   +5 more
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Polymorphism of S-Adenosylhomocysteine Hydrolase in Italy

Human Heredity, 1987
S-adenosylhomocysteine hydrolase (SAHH) polymorphism has been investigated in the Italian population. Three common alleles, SAHH*1, SAHH*2 and SAHH*3, have been observed and the estimated gene frequencies are 0.968, 0.023 and 0.009, respectively. SAHH activity has been assayed in 50 healthy individuals and the mean activity was 0.043 +/- 0.017 mumol ...
CORBO, Rosa Maria, R. Palmarino, E. Schiattarella, M. A. Giannini, R. Scacchi   +4 more
openaire   +3 more sources

Determination of S-Adenosylhomocysteine in Tissues Following Pharmacological Inhibition of S-Adenosylhomocysteine Catabolism

1986
S-Adenosylhomocysteine (AdoHcy) hydrolase (EC 3.3.1.1.), the enzyme responsible for the metabolic degradation of the endogenous transmethylase inhibitor, AdoHcy, is a target enzyme for various adenosine analogues. Some of these compounds have oncostatic and antiviral properties.
S, Helland, P M, Ueland
openaire   +2 more sources

S-Adenosylhomocysteine Hydrolase

1986
S-Adenosylhomocysteine hydrolase (AdoHcyase; EC 3.3.1.1) catalyzes the overall reaction first described by de la Haba and Cantoni (1957):
Peter K. Chiang, George A. Miura
openaire   +1 more source

Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase

Bioorganic & Medicinal Chemistry Letters, 2014
Elevated plasma homocysteine (Hcy) levels are an independent risk factor for the onset and progression of Alzheimer's disease. Reduction of Hcy to normal levels therefore presents a new approach for disease modification. Hcy is produced by the cytosolic enzyme S-adenosylhomocysteine hydrolase (AHCY), which converts S-adenosylhomocysteine (SAH) to Hcy ...
Antonella, Converso, Timothy, Hartingh, Mark E, Fraley, Robert M, Garbaccio, George D, Hartman, Shaei Y, Huang, John M, Majercak, Alexander, McCampbell, Sang Jin, Na, William J, Ray, Mary J, Savage, Carrie, Wolffe, Suzie, Yeh, Yuanjiang, Yu, Rebecca, White, Rena, Zhang   +15 more
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