Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies. [PDF]
PLoS ONE, 2016 Folate deficiency is generally accepted as a potential direct or indirect risk factor for diseases including spina bifida, coronary heart diseases, malfunctions of the central nervous system, and cancer. The direct inclusion of folates in the methylation
Markus Kopp +3 more
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Redox Biology, 2021 Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a range of
Anita Ayer +19 more
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Antioxidants, 2021 In the past, reactive nitrogen species (RNS) were supposed to be stress-induced by-products of disturbed metabolism that cause oxidative damage to biomolecules.
Eva Esther Rudolf +10 more
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Acute ethanol-induced liver injury is prevented by betaine administration
Frontiers in Physiology, 2022 Binge drinking is the most common form of excessive alcohol use. Repeated episodes of binge drinking cause multiple organ injuries, including liver damage.
Madan Kumar Arumugam +19 more
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Functional and Pathological Roles of AHCY
Frontiers in Cell and Developmental Biology, 2021 Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of S-adenosylhomocysteine (SAH), the by-product and a potent inhibitor of methyltransferases activity.
Pedro Vizán +4 more
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S-adenosylhomocysteine metabolism in Streptomyces flocculus [PDF]
Journal of Bacteriology, 1988 S-Adenosylhomocysteine metabolism was studied in cell extracts of streptonigrin-producing Streptomyces flocculus. The major route of metabolism was found to be deamination to form S-inosylhomocysteine. The metabolite was purified by high-performance liquid chromatography and identified by its UV and nuclear magnetic resonance spectra and by its ...
M K, Speedie, J J, Zulty, P, Brothers
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Transsulfuration pathway thiols and methylated arginines: the hunter community study [PDF]
, 2013 Background: Serum homocysteine, when studied singly, has been reported to be positively associated both with the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine [ADMA, via inhibition of dimethylarginine dimethylaminohydrolase ...
Attia, John R. +4 more
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Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]
, 2019 Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna +6 more
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DETERMINATION OF S-ADENOSYLHOMOCYSTEINE IN TISSUES FOLLOWING PHARMACOLOGICAL INHIBITION OF S-ADENOSYLHOMOCYSTEINE CATABOLISM: 84 [PDF]
Pediatric Research, 1985 The amount of S-adenosylhomocysteine in liver increases 2 to 3 fold during the first minute following death of the animal (Hoffman, D.R. et al. (1979) Can. J. Biochem. 57, 56-65), and postmortem increase in AdoHcy should be avoided when determining the physiological level of AdoHcy.
Svein Helland, Per M Ueland
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S-adenosylmethionine and superoxide dismutase 1 synergistically counteract Alzheimer's disease features progression in tgCRND8 mice [PDF]
, 2017 Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer's Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated by one-carbon metabolism ...
Cavallaro, Rosaria A +4 more
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