Results 51 to 60 of about 14,441 (168)

Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress. [PDF]

, 2018
The symposium, "Role of Nutrition in Alcoholic Liver Disease", was held at the European Society for Biomedical Research on Alcoholism Congress on 9 October 2017 in Crete, Greece. The goal of the symposium was to highlight recent advances and developments
Feldstein, Ariel E, Kharbanda, Kusum K, Kirpich, Irina A, McClain, Craig J, Petersen, Dennis R, Ronis, Martin JJ, Shearn, Colin T, Warner, Dennis R, Zakhari, Samir   +8 more
core   +2 more sources

Link between allosteric signal transduction and functional dynamics in a multi-subunit enzyme: S-adenosylhomocysteine hydrolase

, 2011
S-adenosylhomocysteine hydrolase (SAHH), a cellular enzyme that plays a key role in methylation reactions including those required for maturation of viral mRNA, is an important drug target in the discovery of antiviral agents.
Choi, Sun, Hyeon, Changbong, Jeong, Lak Shin, Lee, Yoonji   +3 more
core   +1 more source

Current epigenetic aspects the clinical kidney researcher should embrace [PDF]

, 2017
Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J., Nordfors, Louise, Shiels, Paul G., Stenvinkel, Peter, Van Craenenbroeck, Amaryllis H., Witasp, Anna   +5 more
core   +1 more source

Metabolic perturbation of epigenome by inhibiting -adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells

Tumor Biology, 2017
Cellular senescence is a key physiological barrier against tumor and represents an option for therapeutic intervention. One pivotal intracellular stimulus causing senescence is DNA damage response, while the senescence-associated heterochromatin in ...
Guozhen Wu, Ning Wang, Ying Luo, Yanyan Zhang, Peng Wang, Zhengyan Zhu, Yingtang Gao, Zhi Du, Bin Yang   +8 more
doaj   +1 more source

Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells [PDF]

, 2015
This research was originally published in Journal of Biological Chemistry. Olesya Chayka, Cosimo Walter D’Acunto, Odette Middleton, Maryam Arab, and Arturo Sala.
Arab, M, Chayka, O, D'Acunto, CW, Middleton, O, Sala, A   +4 more
core   +1 more source

Antiparasitic activity of FLLL-32 against four Babesia species, B. bovis, B. bigemina, B. divergens and B. caballi, and one Theileria species, Theileria equi in vitro, and Babesia microti in mice

Frontiers in Pharmacology, 2023
Introduction: FLLL-32, a synthetic analog of curcumin, is a potent inhibitor of STAT3’s constitutive activation in a variety of cancer cells, and its anticancer properties have been demonstrated both in vitro and in vivo.
Shimaa Abd El-Salam El-Sayed, Shimaa Abd El-Salam El-Sayed, El-Sayed El-Alfy, Hanadi B. Baghdadi, Hanadi B. Baghdadi, Mohamed Z. Sayed-Ahmed, Saad S. Alqahtani, Nawazish Alam, Sarfaraz Ahmad, Md. Sajid Ali, Ikuo Igarashi, Mohamed Abdo Rizk   +11 more
doaj   +1 more source

The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver[S]

Journal of Lipid Research, 2011
Retinyl esters are the major chemical forms of vitamin A stored in the liver, and can be delivered to peripheral tissues for conversion into biologically active forms.
Wenqiang Pang, Ying Zhang, Shiming Wang, Aiqun Jia, Wei Dong, Chun Cai, Zichun Hua, Jianfa Zhang   +7 more
doaj   +1 more source

Metabolic Aspects of Adenosine Functions in the Brain

Frontiers in Pharmacology, 2021
Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological and pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning and memory, motor ...
Mercedes Garcia-Gil, Mercedes Garcia-Gil, Marcella Camici, Simone Allegrini, Rossana Pesi, Maria Grazia Tozzi   +5 more
doaj   +1 more source

Co-silencing of tomato S-adenosylhomocysteine hydrolase genes confers increased immunity against Pseudomonas syringae pv. tomato DC3000 and enhanced tolerance to drought stress

Frontiers in Plant Science, 2015
S-adenosylhomocysteine hydrolase (SAHH), catalyzing the reversible hydrolysis of S-adenosylhomocysteine to adenosine and homocysteine, is a key enzyme that maintain the cellular methylation potential in all organisms.
Li Xiao Hui, Lei eHuang, Yongbo eHong, Yafen eZhang, Shixia eLiu, Zhang Hui Juan, Dayong eLi, Fengming eSong   +7 more
doaj   +1 more source

Folate Network Genetic Variation, Plasma Homocysteine, and Global Genomic Methylation Content: A Genetic Association Study [PDF]

, 2013
Background: Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease.
Baccarelli, Andrea, Bollati, Valentina, Cassano, Patricia A, Clark, Andrew G., Gaziano, John Michael, Litonjua, Augusto Ampil, Schwartz, Joel David, Stover, Patrick J, Tucker, Katherine L, Weiss, Scott Tillman, Wells, Martin T, Wernimont, Susan M   +11 more
core   +1 more source