Results 81 to 90 of about 14,441 (168)

SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis. [PDF]

, 2017
Pericyclic reactions-which proceed in a concerted fashion through a cyclic transition state-are among the most powerful synthetic transformations used to make multiple regioselective and stereoselective carbon-carbon bonds.
Chen, Mengbin, Hai, Yang, Houk, KN, Liu, Fang, Ohashi, Masao, Sato, Michio, Tang, Man-Cheng, Tang, Yi, Watanabe, Kenji, Yang, Zhongyue   +9 more
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Transiently elevated plasma methionine, S‐adenosylmethionine and S‐adenosylhomocysteine: Unreported laboratory findings in a patient with NGLY1 deficiency, a congenital disorder of deglycosylation

JIMD Reports, 2019
We report on a 5‐year‐old female born to consanguineous parents, ascertained at the age of 23 months for an elevated plasma methionine level, a mildly abnormal total plasma homocysteine (tHcy), and elevated aminotransferases. She had global developmental
Caitlin A. Chang, Xing‐Chang Wei, Steven R. Martin, David S. Sinasac, Walla Al‐Hertani   +4 more
doaj   +1 more source

Historical Perspectives in the Development of Antiviral Agents Against Poxviruses

Viruses, 2010
The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the ...
Erik De Clercq
doaj   +1 more source

Determinants of the essential one-carbon metabolism metabolites, homocysteine, S-adenosylmethionine, S-adenosylhomocysteine and folate, in cerebrospinal fluid [PDF]

, 2017
Background: Disturbances in the levels of one-carbon (1C) metabolism metabolites have been associated with a wide variety of neuropsychiatric diseases.
Blom, Henk J., Farkas, Melinda, Jessen, Frank, Linnebank, Michael, Popp, Julius, Semmler, Alexander, Smith, Desirée E.C., Smulders, Yvo M.   +7 more
core  

One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond. [PDF]

, 2017
Hyperhomocysteinemia is a risk factor for cognitive decline and dementia, including Alzheimer disease (AD). Homocysteine (Hcy) is a sulfur-containing amino acid and metabolite of the methionine pathway.
Bowman, G.L., Collino, S., Corthésy, J., Da Silva, L., Dayon, L., Descombes, P., Guiraud, S.P., Henry, H., Kussmann, M., Marquis, J., Martin, F.J., Migliavacca, E., Montoliu, I., Moullet, B., Métairon, S., Oikonomidi, A., Popp, J., Tautvydaitė, D., Wojcik, J.   +18 more
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Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries

Biochemistry Research International, 2012
Alcohol is readily distributed throughout the body in the blood stream and crosses biological membranes, which affect virtually all biological processes inside the cell.
Cheng Ji
doaj   +1 more source

Plasma S-adenosylmethionine, DNMT polymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore [PDF]

, 2013
10.1186/1471-2407-13-389BMC Cancer13 ...
Arning, E., Bottiglieri, T., Inoue-Choi, M., Koh, W.-P., Nelson, H.H., Robien, K., Yuan, J.-M.   +6 more
core   +4 more sources

Methionine metabolism in an animal model of sepsis [PDF]

, 2017
Background: Sepsis is a disease with high incidence and lethality and is accompanied by profound metabolic disturbances. In mammalian methionine metabolism, S-adenosylmethionine (SAM) is produced, which is important in the synthesis of neurotransmitters ...
Blom, Henk, Linnebank, Michael, Moskau, Susanna, Semmler, Alexander, Smith, Desiree, Smulders, Yvo, Struys, Eduard   +6 more
core  

The Effects of Cocaine on Different Redox Forms of Cysteine and Homocysteine, and on Labile, Reduced Sulfur in the Rat Plasma Following Active versus Passive Drug Injections [PDF]

, 2013
Received: 28 November 2012 / Revised: 19 April 2013 / Accepted: 6 May 2013 / Published online: 16 May 2013 The Author(s) 2013. This article is published with open access at Springerlink.comThe aim of the present studies was to evaluate cocaine ...
A Madayag, A Meister, AA Tambe, AJ Cooper, CQ Chen, DA Baker, DA Baker, Danuta Kowalczyk-Pachel, DC Carter, DP Jones, E Bald, E Bald, Elżbieta Lorenc-Koci, G Chwatko, G Lund, GJ McBean, GJ McBean, Grażyna Chwatko, H Refsum, H Sato, H Turhan, HJ Forman, HJ Forman, HL Wiener, I Barutcu, I Dalle-Donne, I Dalle-Donne, JB Dietrich, JD Uys, JE Schnitzer, JI Toohey, JJ Mieyal, JM Mato, Joanna Czyżyk, K Fijał, KM Humphries, KS Kau, KS McCully, L Pomierny-Chamioło, L Włodek, LH Lash, Lidia Włodek, M Conrad, M Iciek, M Kemp, M Muriach, MA Evans, Małgorzata Filip, Małgorzata Iciek, NL Reynaert, O Stanger, P Klatt, P Kovacic, PN Mardikian, PW Beatty, PW Kalivas, R Banerjee, R Castro, R Labib, R Labib, RA Kloner, RC Twining, S Githens, S Kandil, S Sengupta, S Zaina, SA Everett, SC Lu, SD LaRowe, SE Hyman, SH Rezkalla, SL Amen, SZ Mehanny, T Fiaschi, T Visalli, V Vitvitsky, W Tian, W Zhou, YI Kim, YM Go, YM Kupchik   +80 more
core   +2 more sources

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
A Freitag, A Gevorgyan, A Mithani, Albert Gevorgyan, AM Feist, AM Feist, AM Feist, Andrzej M. Kierzek, AP Burgard, BA Pfeifer, CS Henry, D Nagrath, DC Alexander, DC Stevens, EM Paradise, Eriko Takano, FC Lee, H Ikeda, I Thiele, J Gonzalez-Lergier, J Romero, J Schellenberger, JD Orth, JL Adrio, JP Brooks, JS Edwards, K Nieselt, K Yanai, LM Blank, M DeJongh, M Durot, M Kanehisa, M Latendresse, MA Fischbach, MA Oberhardt, MA Oberhardt, MA Oberhardt, Marnix H. Medema, MH Medema, MH Medema, MH Medema, MH Medema, MT Alam, MT Alam, MW Covert, N Scherr, ND Price, ND Price, NE Lewis, Piotr Zakrzewski, PR Ives, R Breitling, R Schuetz, Rainer Breitling, SA Becker, SD Bentley, Stephen S. Fong, TD Vo, TY Kim, XQ Zhao   +59 more
core   +6 more sources