Results 71 to 80 of about 4,880 (161)

Losartan API and Nitrosamines Impurities—Stability Profile Investigation Using HPLC, LC‐MS, and In Silico Assessment

Journal of Separation Science, Volume 49, Issue 5, May 2026.
ABSTRACT Nitrosamines are potent genotoxic impurities with well reported mutagenic and carcinogenic effects. Their presence has been detected in several pharmaceutical products among them losartan, an angiotensin II receptor blocker. Considering the risks already reported for these impurities, the present study aimed to investigate the influence of ...
Paulo Roberto Rodrigues Martini, Lilian Fanfa Machioli, Bruno Pereira dos Santos, Tiago Franco de Oliveira, Fávero Reisdorfer Paula, Clésio Soldateli Paim, Andreas Sebastian Loureiro Mendez   +6 more
wiley   +1 more source

Keap1 governs ageing-induced protein aggregation in endothelial cells

Redox Biology, 2020
The breach of proteostasis, leading to the accumulation of protein aggregates, is a hallmark of ageing and age-associated disorders, up to now well-established in neurodegeneration.
Aleksandra Kopacz, Damian Kloska, Marta Targosz-Korecka, Bartłomiej Zapotoczny, Dominik Cysewski, Nicolas Personnic, Ewa Werner, Karolina Hajduk, Alicja Jozkowicz, Anna Grochot-Przeczek   +9 more
doaj   +1 more source

Plasma‐Treated Water Induces Protein Oxidation in Mung Bean (Vigna radiata) and Chickpea (Cicer arietinum) Seedlings

Plasma Processes and Polymers, Volume 23, Issue 5, May 2026.
A schematic showing the plasma device producing RONS into water, PTW applied to chickpea and mung bean seedlings, and resulting effects: (1) increased root growth and (2) detection of specific oxidative protein markers using LC‐MS/MS. ABSTRACT Plasma‐treated water (PTW) is a promising sustainable agricultural resource, yet its effects on seedling ...
Mohammad Bayati, Brijesh K. Tiwari, Mahesha M. Poojary   +2 more
wiley   +1 more source

Methods for Improving Settlement and Metamorphosis of Shelled Marine Mollusks in Aquaculture: A Review

Aquaculture, Fish and Fisheries, Volume 6, Issue 2, April 2026.
Settlement and metamorphosis are key developmental hurdles in marine mollusk aquaculture. Environmental signals (such as biofilms, algae, and signals from conspecifics) and biochemical pathways (including nitric oxide, thyroid hormones, catecholamines, and GABA) regulate the transition of larvae into benthic juveniles. Combining ecological observations
Angelica R. Valdez, Mitchell P. Marabella, Jon‐Paul Bingham   +2 more
wiley   +1 more source

Safe by Design Flow Technology for Diazoacetonitrile Generation and Direct Conversion to Pyrazoles

ChemistryOpen, Volume 15, Issue 4, April 2026.
A safe by design flow process generates diazoacetonitrile (DAN) in water, transfers it with minimal hold up into an organic phase, and immediately consumes it in a telescoped [3 + 2] cycloaddition. Mapping of solvent, temperature, pressure, and residence time windows enables controlled DAN handling and practical access to cyanopyrazoles.
Dušan Bošković, Stefan Loebbecke, Calogero Giancarlo Piscopo, Ligia Johanna Radulescu, Maud Schwarzer   +4 more
wiley   +1 more source

Decomposition Kinetics of Solution and Lyophilized Powder of S‐Nitroso‐N‐Cetylcysteine

Journal of Food Science, Volume 91, Issue 4, April 2026.
ABSTRACT Recently, S‐nitrosothiols (RSNO) have received increased attention in the food industry as replacements for nitrite salts in meat products. However, their industrial applications are limited because of their high instability in concentrated aqueous solutions.
Bruna Fernandes Andrade, Lorrany Ramos do Carmo, Vanelle Maria da Silva, Robledo de Almeida Torres Filho, Paulo Rogério Fontes, Alcinéia de Lemos Souza Ramos, Eduardo Mendes Ramos   +6 more
wiley   +1 more source

In-Gel Detection of S-Nitrosated Proteins Using Fluorescence Methods [PDF]

, 2008
Gel-based detection of protein S-nitrosothiols has relied on the biotin-switch method. This method attempts to replace the nitroso group with a biotin label to allow detection and isolation of S-nitrosated proteins and has been used extensively in the literature. This chapter describes a modification of this method that differs from the original in two
Nicholas J, Kettenhofen, Xunde, Wang, Mark T, Gladwin, Neil, Hogg   +3 more
openaire   +2 more sources

From recognition to response: integrated signaling pathways determining pollen acceptance and rejection in Brassicaceae

New Phytologist, Volume 250, Issue 2, Page 788-798, April 2026.
Summary Generation of competent offspring is vital for the prosperity of flowering plants. The pistil not only functions as a conduit for pollen tubes to grow to the ovary but also provides a selective venue for facilitating the growth of compatible pollen tubes and discouraging invaders and incompatible pollen.
Tong Zhang, Shuyan Li, Shengwei Dou, Qiaohong Duan   +3 more
wiley   +1 more source

Facilitating Nitrite-Derived S-Nitrosothiol Formation in the Upper Gastrointestinal Tract in the Therapy of Cardiovascular Diseases

Antioxidants
Cardiovascular diseases (CVDs) are often associated with impaired nitric oxide (NO) bioavailability, a critical pathophysiological alteration in CVDs and an important target for therapeutic interventions.
Mila Silva-Cunha, Riccardo Lacchini, Jose E. Tanus-Santos   +2 more
doaj   +1 more source

Biochemical methods for monitoring protein thiol redox states in biological systems

Redox Biology, 2014
Oxidative post-translational modifications of proteins resulting from events that increase cellular oxidant levels play important roles in physiological and pathophysiological processes.
Olena Rudyk, Philip Eaton
doaj   +1 more source