Results 61 to 70 of about 4,880 (161)

S-nitrosation of mitochondrial connexin 43 regulates mitochondrial function [PDF]

Basic Research in Cardiology, 2014
S-nitrosation (SNO) of connexin 43 (Cx43)-formed channels modifies dye uptake in astrocytes and gap junctional communication in endothelial cells. Apart from forming channels at the plasma membrane of several cell types, Cx43 is also located at the inner membrane of myocardial subsarcolemmal mitochondria (SSM), but not in interfibrillar mitochondria ...
Soetkamp, Daniel, Nguyen, Tiffany T., Menazza, Sara, Hirschhäuser, Christine, Hendgen-Cotta, Ulrike B., Rassaf, Tienush, Schlüter, Klaus D., Boengler, Kerstin, Murphy, Elizabeth, Schulz, Rainer   +9 more
openaire   +2 more sources

The Physiological Implications of S-Nitrosoglutathione Reductase (GSNOR) Activity Mediating NO Signalling in Plant Root Structures

Antioxidants, 2020
Nitrogen remains an important macronutrient in plant root growth due to its application in amino acid production, in addition to its more elusive role in cellular signalling through nitric oxide (NO).
Leslie Ventimiglia, Bulent Mutus
doaj   +1 more source

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I [PDF]

Nature Medicine, 2013
Oxidative damage from elevated production of reactive oxygen species (ROS) contributes to ischemia-reperfusion injury in myocardial infarction and stroke. The mechanism by which the increase in ROS occurs is not known, and it is unclear how this increase can be prevented.
Chouchani, Edward T., Methner, Carmen, Nadtochiy, Sergiy M., Logan, Angela, Pell, Victoria R., Ding, Shujing, James, Andrew M., Cochemé, Helena M., Reinhold, Johannes, Lilley, Kathryn S., Partridge, Linda, Fearnley, Ian M., Robinson, Alan J., Hartley, Richard C., Smith, Robin A. J., Krieg, Thomas, Brookes, Paul S., Murphy, Michael P.   +17 more
openaire   +3 more sources

A Robust and Universal LC–MS/MS Method for Determination of N‐Nitrosodimethylamine in Pharmaceuticals Using a C30 Column

Journal of Separation Science, Volume 49, Issue 6, June 2026.
ABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
Byungchan An, Unyong Kim, Sumin Seo, Jiyu Kim, Chohee Jeong, Woojin Jeong, Eunjin Ko, Juhyeon Kim, Hyun‐Deok Cho, Sang Beom Han   +9 more
wiley   +1 more source

Antioxidant Properties of S-Nitrosoglutathione and Nanotechnologies

Proceedings, 2019
Cardiovascular diseases are associated with oxidative stress and a reduced bioavailability of nitric oxide (NO). To counteract both processes, the administration of S-nitrosoglutathione (GSNO) can be envisaged.
Marianne Parent, Yi Zhou, Justine Bonetti, Caroline Perrin-Sarrado, Isabelle Lartaud, Anne Sapin-Minet, Caroline Gaucher   +6 more
doaj   +1 more source

The Modus Operandi of Hydrogen Sulfide(H₂S)-Dependent Protein Persulfidation in Higher Plants

Antioxidants, 2021
Protein persulfidation is a post-translational modification (PTM) mediated by hydrogen sulfide (H2S), which affects the thiol group of cysteine residues from target proteins and can have a positive, negative or zero impact on protein function.
Francisco J. Corpas, Salvador González-Gordo, María A. Muñoz-Vargas, Marta Rodríguez-Ruiz, José M. Palma   +4 more
doaj   +1 more source

Unraveling Oral Dysbiosis: Microbial Complexity in Common Oral Diseases

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The oral microbiome undergoes dynamic establishment from birth, maturing into a resilient ecosystem. Perturbation of this homeostasis—driven by dietary, immunological, and anatomical factors—triggers dysbiosis, which underpins the pathogenesis of major oral diseases, including dental caries, periodontal disease, salivary gland disorders, oral mucosal ...
Zixi Kang, Hong Huang, Jin Lin, Yanan Niu, Jiaxin Chen, Jiaxuan Tang, Zhengyuan Hu, Peng Liu, Jun Qu   +8 more
wiley   +1 more source

Hydrogen Gas Enhances Salinity Tolerance in Tomato Seedlings by Regulating the S‐Nitrosylation of MEK1

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3656-3678, June 2026.
ABSTRACT Hydrogen gas (H2) effectively alleviates abiotic stress in horticultural plants. Protein S‐nitrosylation, a key post‐translational modification, serves as a critical mechanism for nitric oxide (NO) to exert its biological function under adverse conditions.
Hua Fang, Xuetong Wu, Dengjing Huang, Xinfang Chen, Zhiya Liu, Xuejuan Pan, Huan Chen, Dandan Zheng, Caicai Ma, Xuemei Hou, Shuya Wang, Chunlei Wang, Weibiao Liao   +12 more
wiley   +1 more source

Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation [PDF]

Biochemical Journal, 2010
The S-nitrosation of mitochondrial proteins as a consequence of NO metabolism is of physiological and pathological significance. We previously developed a MitoSNO (mitochondria-targeted S-nitrosothiol) that selectively S-nitrosates mitochondrial proteins. To identify these S-nitrosated proteins, here we have developed a selective proteomic methodology,
Chouchani, Edward, Hurd, Thomas, Nadtochiy, Sergiy M, Brookes, Paul S, Fearnley, Ian M., Lilley, Kathryn S, Smith, Robin Andrew James, Murphy, Michael P   +7 more
openaire   +2 more sources

Redox-sensitivity and site-specificity of S- and N- denitrosation in proteins. [PDF]

PLoS ONE, 2010
S-nitrosation--the formation of S-nitrosothiols (RSNOs) at cysteine residues in proteins--is a posttranslational modification involved in signal transduction and nitric oxide (NO) transport.
Frances L Jourd'heuil, Anthony M Lowery, Elaina M Melton, Sanie Mnaimneh, Nathan S Bryan, Bernadette O Fernandez, Joo-Ho Park, Chung-Eun Ha, Nadhipuram V Bhagavan, Martin Feelisch, David Jourd'heuil   +10 more
doaj   +1 more source