Results 91 to 100 of about 22,830,963 (211)
Juxta-membrane S-acylation of plant receptor-like kinases is likely fortuitous and does not necessarily impact upon function [PDF]
, 2019 This work was funded by UK Biotechnology and Biological Sciences Research Council Grants BB/M024911/1 and BB/M010996/1 to P.A.H.S-acylation is a common post-translational modification of membrane protein cysteine residues with many regulatory roles.
Hemsley, Piers +5 more
core +4 more sources
Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia [PDF]
Schizophrenia Research, 2016 Recent reports suggest abnormalities of neurotransmitter receptor trafficking, targeting, dendritic localization, recycling, and degradation in the brain in schizophrenia. We hypothesized that a potential explanation for these findings may be abnormal posttranslational modifications that influence intracellular targeting and trafficking of proteins ...
Anita L, Pinner +4 more
openaire +2 more sources
Noncanonical Amino Acids in the Interrogation of Cellular Protein Synthesis [PDF]
, 2011 Proteins in living cells can be made receptive to bioorthogonal chemistries through metabolic labeling with appropriately designed noncanonical amino acids (ncAAs).
Ngo, John T., Tirrell, David A.
core +2 more sources
Advanced Science, EarlyView.Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng +12 more
wiley +1 more source
Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo [PDF]
Nature Communications, 2020 ABSTRACTPeripheral membrane proteins (PMPs) associate with cellular membranes through post-translational modifications like S-palmitoylation. The Golgi apparatus is generally viewed as the transitory station where palmitoyl acyltransferases (PATs) modify PMPs, which are then transported to their ultimate destinations such as the plasma membrane (PM ...
Solis, Gonzalo +6 more
openaire +4 more sources
Palmitoylation of ACE2 at Cys141, Cys344, and Cys498 facilitates its extracellular vesicles localization [PDF]
Jichu yixue yu linchuangObjective To identify S-palmitoylation sites on angiotensin-converting enzyme 2(ACE2), the cellular receptor for severe acute respiratory syndrome corona virus(SARS-CoV) and SARS-CoV-2, and to investigate the functional relevance of these modifications ...
YANG Jingjing, MA Yan, WANG Yue, SUN Yang, LI Pan, GUO Feng
doaj +1 more source
Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells. [PDF]
, 2018 A sensitization of inositol 1,4,5-trisphosphate receptor (IP3R)-mediated Ca2+ release is associated with oxidative stress in multiple cell types. These effects are thought to be mediated by alterations in the redox state of critical thiols in the IP3R ...
Ali, Mehboob +6 more
core +1 more source
New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness [PDF]
, 2017 Infections by protozoan parasites, such as Plasmodium falciparum or Leishmania donovani, have a significant health, social and economic impact and threaten billions of people living in tropical and sub-tropical regions of developing countries worldwide ...
EDWARD W. TATE +4 more
core +1 more source
Advanced Science, EarlyView.Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan +11 more
wiley +1 more source
Protein palmitoylation in cancer: molecular functions and therapeutic potential
Molecular Oncology, 2023 Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family.
Binhui Zhou +3 more
doaj +1 more source