Results 111 to 120 of about 22,830,963 (211)

Protein Palmitoylation and Its Role in Bacterial and Viral Infections

Frontiers in Immunology, 2018
S-palmitoylation is a reversible, enzymatic posttranslational modification of proteins in which palmitoyl chain is attached to a cysteine residue via a thioester linkage.
Justyna Sobocińska, Paula Roszczenko-Jasińska, Anna Ciesielska, Katarzyna Kwiatkowska   +3 more
doaj   +1 more source

An Amphipathic α-Helix Directs Palmitoylation of the Large Intracellular Loop of the Sodium/Calcium Exchanger [PDF]

, 2017
The electrogenic sodium/calcium exchanger (NCX) mediates bidirectional calcium transport controlled by the transmembrane sodium gradient. NCX inactivation occurs in the absence of phosphatidylinositol 4,5-bisphosphate and is facilitated by palmitoylation
Blanc, Chaptal, Drozdetskiy, Fukata, Fuller, Giladi, Hilge, Hilgemann, Howie, John, Kumari, Lemonidis, Lemonidis, Li, Liao, Linder, Lytton, Maack, Matsuoka, Matsuoka, Nadolski, Nicoll, Ottolia, Philipson, Reddy, Reilly, Reményi, Ren, Ren, Rocks, Shipston, Thomas   +31 more
core   +3 more sources

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity

Viruses, 2022
The spike proteins of enveloped viruses are transmembrane glycoproteins that typically undergo post-translational attachment of palmitate on cysteine residues on the cytoplasmic facing tail of the protein.
Ahmed A. Ramadan, Karthick Mayilsamy, Andrew R. McGill, Anandita Ghosh, Marc A. Giulianotti, Haley M. Donow, Shyam S. Mohapatra, Subhra Mohapatra, Bala Chandran, Robert J. Deschenes, Arunava Roy   +10 more
doaj   +1 more source

Chemical proteomics: a powerful tool for exploring protein lipidation [PDF]

, 2013
The study of post-translational modifications such as protein lipidation is a non-trivial challenge of the post-genomic era. In recent years the field of chemical proteomics has greatly advanced our ability to identify and quantify protein lipidation. In
Serwa, RA, Storck, EM, Tate, EW
core   +1 more source

Differential S-palmitoylation of the human and rodent β3-adrenergic receptors [PDF]

Journal of Biological Chemistry, 2019
With few reported exceptions, G protein-coupled receptors (GPCRs) are modified by Cys palmitoylation (S-palmitoylation). In multiple GPCRs, S-palmitoylation targets a canonical site within the C-terminal cytoplasmic tail adjacent to the C terminus of the seventh transmembrane domain, but modification of additional sites is exemplified by the β ...
Naoko Adachi, Douglas T. Hess, Mika Kaku, Chie Ueda, Chisato Numa, Naoaki Saito   +5 more
openaire   +2 more sources

Greasing the wheels or a spanner in the works?:Regulation of the cardiac sodium pump by palmitoylation [PDF]

, 2018
The ubiquitous sodium/potassium ATPase (Na pump) is the most abundant primary active transporter at the cell surface of multiple cell types, including ventricular myocytes in the heart.
Fiona Plain, Jacqueline Howie, Kakar SS, Krzysztof J. Wypijewski, Lindsay B. Tulloch, Mullins LJ., Niall J. Fraser, Pitts BJ, Presti CF, Presti CF, William Fuller   +10 more
core   +3 more sources

Proteome‐Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling

PROTEOMICS, EarlyView.
ABSTRACT Protein S‐palmitoylation, a reversible lipid modification, plays critical roles in regulating protein function and localization. However, its comprehensive role in the rapid reprogramming of macrophages during early immune responses remains incompletely understood.
Hyojung Kim, Jiraphorn Issara‐Amphorn, Sung Hwan Yoon, Anirban Banerjee, Aleksandra Nita‐Lazar   +4 more
wiley   +1 more source

Bat and pig IFN-induced transmembrane protein 3 restrict cell entry by influenza virus and lyssaviruses [PDF]

, 2015
IFN-induced transmembrane protein 3 (IFITM3) is a restriction factor that blocks cytosolic entry of numerous viruses that utilize acidic endosomal entry pathways. In humans and mice, IFITM3 limits influenza-induced morbidity and mortality.
Benfield, C., Benfield, C., Ferrara, F., Ferrara, F., Kellam, P., Kellam, P., Smith, S.E., Smith, S.E., Temperton, N.J., Temperton, N.J., Wash, R.S., Wash, R.S., Wright, E., Wright, E.   +13 more
core   +5 more sources

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source