Results 131 to 140 of about 22,830,963 (211)

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70‐Mediated Ubiquitin Ligase Pathway

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So, In‐Kang Song, Yeon Jung Kim, Yeonjoo Lee, Yeon Seung Park, Hee‐Jung Kim, Kong‐Joo Lee, Eun Joo Song   +7 more
wiley   +1 more source

Global, site-specific analysis of neuronal protein S-acylation

Scientific Reports, 2017
Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins however, methods for comprehensive ...
Mark O. Collins, Keith T. Woodley, Jyoti S. Choudhary   +2 more
doaj   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

S-palmitoylation and depalmitoylation at the interface of animal virus-host interactions

Frontiers in Cellular and Infection Microbiology
Reversible protein S-palmitoylation, mediated by protein acyl transferases (PATs) and depalmitoylases, is essential for regulating numerous biological processes, including subcellular localization, protein stability, enzymatic activity, and protein ...
Rui-Qin Xu, Rui-Qin Xu, Xi-Meng Chen, Chen-Rong Wang, Shi-Jie Ma, Shi-Jie Ma, Shi-Jie Ma, Ping-Li Wang, Ping-Li Wang, Ping-Li Wang, Hong-Ying Chen, Hong-Ying Chen, Hong-Ying Chen   +12 more
doaj   +1 more source

Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey [PDF]

, 2014
Short linear motifs (SLiMs) are functional stretches of protein sequence that are of crucial importance for numerous biological processes by mediating protein–protein interactions.
Ambarnil Ghosh, Catrióna R. Johnston, Daniel Hurley, Denis C. Shields, Heini Ruhanen, Kevin T. O'Brien   +5 more
core   +1 more source

Cholesterol‐DNA Origami Nanostructures for Synthetic Lipid Rafts Induce Early T Cell Activation Signals

Advanced Materials Interfaces, Volume 13, Issue 5, 4 March 2026.
Here, we present a nanotechnology approach to construct synthetic lipid rafts on the live T cell membrane, leveraging a versatile DNA origami‐enabled platform named as the “cholesterol nano‐patch” (CNP). Our investigation highlights the effectiveness of DNA nanotechnology in exploring the impact of nanoscale arrangement of cholesterols on the ...
Yunmin Jung, Young‐Joo Kim, Kunwoo Noh, Sunmi Lee, Minsuk Kwak   +4 more
wiley   +1 more source

Post‐Translational Modifications in Animal Circadian Clocks

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley   +1 more source

HSDL2 Suppresses Epileptic Seizures Through Phosphorylation‐Dependent Modulation of the PSD95‐NMDAR Signaling Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
In a kainic acid‐induced mouse model of epilepsy, upregulation of HSDL2 in the hippocampus prolonged seizure latency, increased the membrane expression of PSD95, and enhanced its phosphorylation. Concurrently, HSDL2 attenuated the interaction between PSD95 and the NMDAR subunits GluN2A/GluN2B, thereby suppressing NMDAR overactivation, reducing ...
Yan Xia, Wang Jing, Zhang Hui, Xu Demei, Peng Xi, Wang Liang   +5 more
wiley   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source