The type 3 secretion effector IpgD promotes S. flexneri dissemination. [PDF]
PLoS Pathog, 2022 The bacterial pathogen Shigella flexneri causes 270 million cases of bacillary dysentery worldwide every year, resulting in more than 200,000 deaths. S. flexneri pathogenic properties rely on its ability to invade epithelial cells and spread from cell to cell within the colonic epithelium.
Köseoğlu VK, Jones MK, Agaisse H.
europepmc +7 more sources
Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant
mSphere, 2020 Shigella is the second leading cause of bacterial diarrhea worldwide. Recently, Shigella sonnei seems to be replacing Shigella flexneri in low- and middle-income countries undergoing economic development.
Dhiviya Prabaa Muthuirulandi Sethuvel +8 more
doaj +4 more sources
Impact of O-Acetylation on S. flexneri 1b and 2a O-Antigen Immunogenicity in Mice. [PDF]
Microorganisms, 2021 Shigellosis is a diarrheal disease caused prevalently by Shigella flexneri and S. sonnei and representing a major global health risk, particularly in developing countries. Bacterial O-antigen (OAg) is the primary target of the host immune response and modifications of its oligosaccharide units, including O-acetylation, are responsible for the ...
Arato V +5 more
europepmc +8 more sources
Rationalizing the design of a broad coverage Shigella vaccine based on evaluation of immunological cross-reactivity among S. flexneri serotypes. [PDF]
PLoS Neglected Tropical Diseases, 2021 No vaccine to protect against an estimated 238,000 shigellosis deaths per year is widely available. S. sonnei is the most prevalent Shigella, and multiple serotypes of S. flexneri, which change regionally and globally, also cause significant disease. The
Francesco Citiulo +11 more
doaj +3 more sources
Development of Shigella conjugate vaccines targeting Shigella flexneri 2a and S. flexneri 3a using a simple platform-approach conjugation by squaric acid chemistry. [PDF]
Vaccine, 2023 There is a need for vaccines effective against shigella infection in young children in resource-limited areas. Protective immunity against shigella infection targets the O-specific polysaccharide (OSP) component of lipopolysaccharide. Inducing immune responses to polysaccharides in young children can be problematic, but high level and durable responses
Kelly M +19 more
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Identification of a putative pathogenicity island inShigella flexneriusing subtractive hybridisation of theS. flexneriandEscherichia coligenomes [PDF]
FEMS Microbiology Letters, 2002 The genetic differences between the human pathogen, Shigella flexneri, and the non-pathogenic Escherichia coli were investigated in an attempt to identify pathogenicity islands (PAIs) in the S. flexneri genome. Genomic subtraction identified a large unique region of DNA which was present in S. flexneri serotype 2a but absent from E. coli K-12.
John C. Walker, Naresh K. Verma
semanticscholar +5 more sources
Key residues of S. flexneri OmpA mediate infection by bacteriophage Sf6. [PDF]
J Mol Biol, 2015 Many viruses, including bacteriophage, have the inherent ability to utilize several types of proteinaceous receptors as an attachment mechanism to infect cells, yet the molecular mechanisms that drive receptor binding have not been elucidated. Using bacteriophage Sf6 and its host, Shigella flexneri, we investigated how Sf6 utilizes outer membrane ...
Porcek NB, Parent KN.
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Cross Protectivity Analysis of 49.8 kDa Pili Subunits of S. flexneri against Vibrio cholerae Infection. [PDF]
Interdiscip Perspect Infect Dis, 2022 Background. Although the AMV and AMS vaccine candidates have similar characteristics as hemagglutinin and adhesive molecules, there are differences in molecular weight. Objective. The research aims to determine the immunological cross-reaction between AMS and AMV. Method. Antihemagglutination test used the anti-adhesion molecular antibody AMS. Next, we
Yuni Nur Hidayati D +8 more
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Expression of Shigella dysenteriae serotype 1 O-antigenic polysaccharide by Shigella flexneri aroD vaccine candidates and different S. flexneri serotypes [PDF]
Journal of Bacteriology, 1995 The potential utility of Shigella flexneri aroD vaccine candidates for the development of bi- or multivalent vaccines has been explored by the introduction of the genetic determinants rfp and rfb for heterologous O antigen polysaccharide from Shigella dysenteriae serotype 1.
Inger Fält +6 more
semanticscholar +4 more sources
Acetylation of O-specific lipopolysaccharides from Shigella flexneri 3a and 2a occurs in Escherichia coli K-12 carrying cloned S. flexneri 3a and 2a rfb genes [PDF]
Journal of Bacteriology, 1992 Most of the Shigella flexneri O-specific serotypes result from O-acetyl and/or glucosyl groups added to a common O-repeating unit of the lipopolysaccharide (LPS) molecule. The genes involved in acetylation and/or glucosylation of S. flexneri LPS are physically located on lysogenic bacteriophages, whereas the rfb cluster contains the biosynthesis genes ...
Zhijian Yao, Hong Liu, Miguel A. Valvano
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