P1 phagemid-based delivery of Cas9 antimicrobial into Shigella flexneri [PDF]
A bacteriophage P1 phagemid system allowed efficient packaging of a DNA-sequence specific, Cas9 antimicrobial into transducing particles, which could be used to infect and kill pathogenic bacteria, such as Shigella flexneri. Although the transduction
Huan, Yang Wei
core +1 more source
Shigella flexneri is a major diarrhoeal pathogen, and the emergence of multidrug-resistant S. flexneri is of public health concern. We report the detection of a clonal cluster of multidrug-resistant serotype 1c (7a) S. flexneri in Singapore in April 2022.
Karrie K. K. Ko +28 more
doaj +1 more source
Correction article: The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance. [PDF]
: This is a correction of an earlier submitted ...
Corwin Andrew L +80 more
core +6 more sources
GROWTH, SURVIVAL AND ADAPTATION OF Shigella flexneri UNDER ACIDIC CONDITIONS RELEVANT TO THOSE APPLIED DURING DAIRY PROCESSING [PDF]
Shigella flexneri is an important fooborne pathogen that has been associated with dairy products. This study aimed to assess the growth, survival and adaptation of S. flexneri under acidic conditions relevant to those adopted in dairy processing.
Marwa El-Nabawy +2 more
doaj +1 more source
Shigella flexneri is a waterborne and foodborne pathogen that can damage human health. The exopolysaccharides (S-EPS) produced by S. flexneri CMCC51574 were found to promote biofilm formation and virulence. In this research, the crude S-EPS produced by S.
Yinglong Song +5 more
doaj +1 more source
P1 Bacteriophage-Enabled Delivery of CRISPR-Cas9 Antimicrobial Activity Against Shigella flexneri [PDF]
The discovery of clustered, regularly interspaced, short palindromic repeats (CRISPR) and the Cas9 RNA-guided nuclease provides unprecedented opportunities to selectively kill specific populations or species of bacteria.
Serge Mostowy +7 more
core +1 more source
Bacteroides spp. modulate Shigella flexneri virulence [PDF]
Shigella flexneri causes bacterial dysentery in humans, leading to high rates of morbidity and mortality each year. While much is known about the invasive process and intracellular lifecycle of S.
Xerri, Nicholas Leonard
core +1 more source
The effect of the potential PhoQ histidine kinase inhibitors on Shigella flexneri virulence. [PDF]
PhoQ/PhoP is an important two-component system that regulates Shigella virulence. We explored whether the PhoQ/PhoP system is a promising target for new antibiotics against S. flexneri infection.
Xia Cai +9 more
doaj +1 more source
Capsaicin Inhibits Shigella flexneri Intracellular Growth by Inducing Autophagy
Antibiotic treatment plays an essential role in preventing Shigella infection. However, incidences of global rise in antibiotic resistance create a major challenge to treat bacterial infection.
Priyanka Basak +6 more
doaj +1 more source
The epidemiology of S. sonnei and S. flexneri in Pima County, Arizona: an exploratory study. [PDF]
Investigation of 189 cases of shigellosis reported to the Pima County, Arizona Health Department in 1986 revealed that 23 per cent of cases could be attributed to travel to Mexico, and 10 per cent to day care attendees and their household contacts.
S C, McCombie +3 more
openaire +2 more sources

