The type 3 secretion effector IpgD promotes S. flexneri dissemination. [PDF]
PLoS Pathog, 2022 The bacterial pathogen Shigella flexneri causes 270 million cases of bacillary dysentery worldwide every year, resulting in more than 200,000 deaths. S. flexneri pathogenic properties rely on its ability to invade epithelial cells and spread from cell to cell within the colonic epithelium.
Köseoğlu VK, Jones MK, Agaisse H.
europepmc +5 more sources
Rationalizing the design of a broad coverage Shigella vaccine based on evaluation of immunological cross-reactivity among S. flexneri serotypes. [PDF]
PLoS Neglected Tropical Diseases, 2021 No vaccine to protect against an estimated 238,000 shigellosis deaths per year is widely available. S. sonnei is the most prevalent Shigella, and multiple serotypes of S. flexneri, which change regionally and globally, also cause significant disease. The
Francesco Citiulo +11 more
doaj +2 more sources
Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant
mSphere, 2020 Shigella is the second leading cause of bacterial diarrhea worldwide. Recently, Shigella sonnei seems to be replacing Shigella flexneri in low- and middle-income countries undergoing economic development.
Dhiviya Prabaa Muthuirulandi Sethuvel +8 more
doaj +2 more sources
Development of Shigella conjugate vaccines targeting Shigella flexneri 2a and S. flexneri 3a using a simple platform-approach conjugation by squaric acid chemistry. [PDF]
Vaccine, 2023 There is a need for vaccines effective against shigella infection in young children in resource-limited areas. Protective immunity against shigella infection targets the O-specific polysaccharide (OSP) component of lipopolysaccharide. Inducing immune responses to polysaccharides in young children can be problematic, but high level and durable responses
Kelly M +19 more
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Impact of O-Acetylation on S. flexneri 1b and 2a O-Antigen Immunogenicity in Mice. [PDF]
Microorganisms, 2021 Shigellosis is a diarrheal disease caused prevalently by Shigella flexneri and S. sonnei and representing a major global health risk, particularly in developing countries. Bacterial O-antigen (OAg) is the primary target of the host immune response and modifications of its oligosaccharide units, including O-acetylation, are responsible for the ...
Arato V +5 more
europepmc +5 more sources
Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides. [PDF]
Sci Rep, 2021 AbstractEnzyme engineering approaches have allowed to extend the collection of enzymatic tools available for synthetic purposes. However, controlling the regioselectivity of the reaction remains challenging, in particular when dealing with carbohydrates bearing numerous reactive hydroxyl groups as substrates.
Benkoulouche M +12 more
europepmc +6 more sources
Key residues of S. flexneri OmpA mediate infection by bacteriophage Sf6. [PDF]
J Mol Biol, 2015 Many viruses, including bacteriophage, have the inherent ability to utilize several types of proteinaceous receptors as an attachment mechanism to infect cells, yet the molecular mechanisms that drive receptor binding have not been elucidated. Using bacteriophage Sf6 and its host, Shigella flexneri, we investigated how Sf6 utilizes outer membrane ...
Porcek NB, Parent KN.
europepmc +4 more sources
Bacteroides thetaiotaomicron Outer Membrane Vesicles Modulate Virulence of Shigella flexneri
MBio, 2022 The role of the gut microbiota in the pathogenesis of Shigella flexneri remains largely unknown. To understand the impact of the gut microbiota on S.
Shelley M Payne
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Shigella flexneri Infection in Caenorhabditis elegans: Cytopathological Examination and Identification of Host Responses [PDF]
PLoS ONE, 2014 The Gram-negative bacterium Shigella flexneri is the causative agent of shigellosis, a diarrhoeal disease also known as bacillary dysentery. S. flexneri infects the colonic and rectal epithelia of its primate host and induces a cascade of inflammatory ...
Carolyn A Behm +2 more
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Characterisation of Early Mucosal and Neuronal Lesions Following Shigella flexneri Infection in Human Colon [PDF]
PLoS ONE, 2009 BACKGROUND: Shigella, an enteroinvasive bacteria induces a major inflammatory response responsible for acute rectocolitis in humans. However, early effect of Shigella flexneri (S.
Philippe Aubert +2 more
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