Rationalizing the design of a broad coverage Shigella vaccine based on evaluation of immunological cross-reactivity among S. flexneri serotypes. [PDF]
PLoS Neglected Tropical Diseases, 2021 No vaccine to protect against an estimated 238,000 shigellosis deaths per year is widely available. S. sonnei is the most prevalent Shigella, and multiple serotypes of S. flexneri, which change regionally and globally, also cause significant disease. The
Francesco Citiulo +11 more
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Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant
mSphere, 2020 Shigella is the second leading cause of bacterial diarrhea worldwide. Recently, Shigella sonnei seems to be replacing Shigella flexneri in low- and middle-income countries undergoing economic development.
Dhiviya Prabaa Muthuirulandi Sethuvel +8 more
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Bacteroides thetaiotaomicron Outer Membrane Vesicles Modulate Virulence of Shigella flexneri.
MBio, 2022 The role of the gut microbiota in the pathogenesis of Shigella flexneri remains largely unknown. To understand the impact of the gut microbiota on S.
Shelley M Payne
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Shigella flexneri Infection in Caenorhabditis elegans: Cytopathological Examination and Identification of Host Responses [PDF]
PLoS ONE, 2014 The Gram-negative bacterium Shigella flexneri is the causative agent of shigellosis, a diarrhoeal disease also known as bacillary dysentery. S. flexneri infects the colonic and rectal epithelia of its primate host and induces a cascade of inflammatory ...
Naresh Verma +2 more
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Characterisation of Early Mucosal and Neuronal Lesions Following Shigella flexneri Infection in Human Colon [PDF]
PLoS ONE, 2009 BACKGROUND: Shigella, an enteroinvasive bacteria induces a major inflammatory response responsible for acute rectocolitis in humans. However, early effect of Shigella flexneri (S.
Philippe Aubert +2 more
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Identification, antimicrobial susceptibility test, and pathogenicity analysis of Shigella flexneri from cynomolgus monkey (Macaca fascicularis) [PDF]
Frontiers in MicrobiologyIntroductionShigella flexneri (S. flexneri) is an important zoonotic pathogen. Infections caused by this bacterium in nonhuman primates, especially cynomolgus monkeys (Macaca fascicularis), represent major health risks and biosecurity concerns for ...
Ziyao Qian +7 more
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Host response to bacteria induces a shift towards the enteroendocrine cell lineage in the murine enteroid model. [PDF]
PLoS PathogensThe host response to commensal and pathogenic bacteria has been extensively characterized using human cancer cell line models but remains less defined in primary intestinal cellular systems. Recent evidence has demonstrated that mice lacking the Nod-like
Marry Nissan +9 more
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Shigella flexneri and Shigella sonnei among children under five in Kenya’s urban informal settlement [PDF]
Gut PathogensBackground Shigella species are a significant global public health threat with the highest burden of Shigella-associated diarrhoea in children under five years of age, particularly in low- and middle-income countries. Given the high burden of shigellosis
Christine Kioko +12 more
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Genome-wide analysis exploring mechanisms used by Shigella sonnei to survive long-term nutrient starvation [PDF]
mSystemsShigella is a major cause of severe diarrhea, with Shigella flexneri and Shigella sonnei accounting for over 90% of infections. Progressive economic growth worldwide correlates with the replacement of S. flexneri by S.
Xosé M. Matanza +6 more
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International Journal of Infectious Diseases, 2021 Objectives: Shigella flexneri (S. flexneri) is prevalent worldwide and the most common Shigella in many countries, causing highly contagious diarrhea, which seriously threatens public health.
Yaoqiang Shi +5 more
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