Bacteroides thetaiotaomicron Outer Membrane Vesicles Modulate Virulence of Shigella flexneri
mBio, 2022 The role of the gut microbiota in the pathogenesis of Shigella flexneri remains largely unknown. To understand the impact of the gut microbiota on S.
Nicholas L. Xerri, Shelley M. Payne
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Capsaicin Inhibits Shigella flexneri Intracellular Growth by Inducing Autophagy
Frontiers in Pharmacology, 2022 Antibiotic treatment plays an essential role in preventing Shigella infection. However, incidences of global rise in antibiotic resistance create a major challenge to treat bacterial infection.
Priyanka Basak +6 more
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Frontiers in Bioengineering and Biotechnology, 2022 Shigella flexneri is a serious threat to global public health, and a rapid detection method is urgently needed. The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated) system is widely used in gene editing, gene ...
Yaoqiang Shi +9 more
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Redirecting substrate regioselectivity using engineered ΔN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens. [PDF]
Sci Rep, 2021 Benkoulouche M +11 more
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The epidemiology of S. sonnei and S. flexneri in Pima County, Arizona: an exploratory study. [PDF]
American Journal of Public Health, 1988 Investigation of 189 cases of shigellosis reported to the Pima County, Arizona Health Department in 1986 revealed that 23 per cent of cases could be attributed to travel to Mexico, and 10 per cent to day care attendees and their household contacts.
S.C. McCombie +3 more
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Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexneri [PDF]
eLife, 2015 Shigella flexneri is the most common cause of bacterial dysentery in low-income countries. Despite this, S. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on serotyping reactions developed ...
Thomas R Connor +19 more
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mSphere, 2023 ABSTRACT The Shigella artificial invasin complex (Invaplex AR ) vaccine is a subunit approach that effectively induces robust immunogenicity directed to serotype-specific lipopolysaccharide and the broadly conserved IpaB and IpaC proteins.
K. Ross Turbyfill +5 more
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IFNγ inhibits the cytosolic replication of Shigella flexneri via the cytoplasmic RNA sensor RIG-I. [PDF]
PLoS Pathogens, 2012 The activation of host cells by interferon gamma (IFNγ) is essential for inhibiting the intracellular replication of most microbial pathogens. Although significant advances have been made in identifying IFNγ-dependent host factors that suppress ...
Stephanie P Jehl +3 more
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A new gut pathogenic bacteria and its metabolites promote colorectal cancer development and act as non-invasive early diagnostic biomarkers [PDF]
Gut MicrobesGut microbiota dysbiosis is strongly linked to colorectal cancer (CRC), but reliable early diagnostic markers remain elusive. This study investigates the role of a novel Shigella flexneri strain in CRC pathogenesis.
Rui Zhang +7 more
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High-content high-resolution microscopy and deep learning-assisted analysis reveals host and bacterial heterogeneity during Shigella infection [PDF]
eLifeShigella flexneri is a Gram-negative bacterial pathogen and causative agent of bacillary dysentery. S. flexneri is closely related to Escherichia coli but harbours a virulence plasmid that encodes a type III secretion system (T3SS) required for host cell
Ana Teresa López-Jiménez +5 more
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