Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family. [PDF]
PLoS ONE, 2016 The S100 proteins are a large family of signaling proteins that play critical roles in biology and disease. Many S100 proteins bind Zn2+, Cu2+, and/or Mn2+ as part of their biological functions; however, the evolutionary origins of binding remain obscure.
Lucas C Wheeler +3 more
doaj +1 more source
Promiscuity mapping of the S100 protein family using a high-throughput holdup assay
Scientific Reports, 2022 S100 proteins are small, typically homodimeric, vertebrate-specific EF-hand proteins that establish Ca2+-dependent protein–protein interactions in the intra- and extracellular environment and are overexpressed in various pathologies.
Márton A. Simon +8 more
doaj +1 more source
Influence of S100A2 in Human Diseases
Diagnostics, 2022 S100 proteins are a family of low-molecular-weight proteins characterized by two calcium-binding sites with a helix-loop-helix (“EF-hand-type”) domain.
Hitomi Sugino, Yu Sawada
doaj +1 more source
Certainty of S100 from Physiology to Pathology [PDF]
Journal of Clinical and Diagnostic Research, 2016 S100 exists in wide variety of tissues and cell types, originally isolated from brain tissue and they are of low molecular weight proteins. S100 is evenly distributed in cytoplasm and also in nucleoplasm and is involved in both intercellular and ...
Puneeth Horatti Kuberappa +4 more
doaj +1 more source
S100s and HMGB1 Crosstalk in Pancreatic Cancer Tumors
Biomolecules, 2023 Pancreatic cancer remains a disease that is very difficult to treat. S100 proteins are small calcium binding proteins with diverse intra- and extracellular functions that modulate different aspects of tumorigenesis, including tumor growth and metastasis.
Angelo Mandarino +5 more
doaj +1 more source
S100A6 protein negatively regulates CacyBP/SIP-mediated inhibition of gastric cancer cell proliferation and tumorigenesis. [PDF]
PLoS ONE, 2012 Calcyclin-binding protein (CacyBP/SIP), identified on the basis of its ability to interact with S100 proteins in a calcium-dependent manner, was previously found to inhibit the proliferation and tumorigenesis of gastric cancer cells in our laboratory ...
Xiaoxuan Ning +6 more
doaj +1 more source
Multifunctional Role of S100 Protein Family in the Immune System: An Update
Cells, 2022 S100 is a broad subfamily of low-molecular weight calcium-binding proteins (9–14 kDa) with structural similarity and functional discrepancy. It is required for inflammation and cellular homeostasis, and can work extracellularly, intracellularly, or both.
Parul Singh, Syed Azmal Ali
doaj +1 more source
Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins. [PDF]
PLoS ONE, 2013 S100 proteins are small dimeric calcium-binding proteins which control cell cycle, growth and differentiation via interactions with different target proteins.
Sofia B Carvalho +5 more
doaj +1 more source
Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function [PDF]
, 2009 Background Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders.
Moroz, Olga V. +13 more
core +2 more sources
Significance of Elecsys (R) S100 immunoassay for real-time assessment of traumatic brain damage in multiple trauma patients [PDF]
, 2006 Background: The neuroprotein S100 released into the circulation has been suggested as a reliable marker for primary brain damage. However, safe identification of relevant traumatic brain injury (TBI) may possibly be hampered by S100 release from ...
Alber +38 more
core +1 more source