Results 131 to 140 of about 1,634,918 (305)

Table S1; Fig. S1; Appendix S1; Figure S2; Figure S3; Figure S4 from Dodging silver bullets: good CRISPR gene-drive design is critical for eradicating exotic vertebrates.

, 2017
Demographic parameters used for the stochastic individual-based model.; Diagram of the individual-based model structure and flow.; R function to calculate transition probabilities (Psj) for germline homing, assuming simultaneous expression of multiplexed gRNAs.; Impact of reproductive compensation on the homozygotic embryonic non-viability strategy ...
Prowse, Thomas A. A., Cassey, Phillip, Ross, Joshua V., Pfitzner, Chandran, Wittmann, Talia, Thomas, Paul   +5 more
openaire   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

GENETIC POLYMORPHISM OF MILK PROTEINS IN BARBARI GOATS

Tropical and Subtropical Agroecosystems, 2009
Milk samples of 178 Barbari goats, maintained at the Central Institute for Research on Goats, Makhdoom, Mathura, Uttar Pradesh, India, were analyzed to study the genetic polymorphisms of milk proteins in this breed.
Namita Garg, Staendra K. Singh, Pramod Kumar Rout, Ajoy Mandal   +3 more
doaj  

SARS-CoV-2 spike protein causes synaptic dysfunction and p-tau and α-synuclein aggregation leading cognitive impairment: The protective role of metformin.

PLoS ONE
Patients recovering from post-coronavirus disease 2019 (COVID-19) often experience cognitive dysfunction, including difficulties with focusing, conversation, or memory issues, which can persist for weeks or even months after infection.
Hye-Kyung Lee, Ji Young Choi, Jung Hyun Park, Moon Han Chang, Jung Ho Park, Young Ho Koh   +5 more
doaj   +1 more source

PCR-Based investigation of virulence genes in Streptococcus sobrinus isolated from dental caries

Babcock University Medical Journal
Objective: Streptococcus sobrinus is a highly cariogenic, acidogenic, and strong biofilm-forming species. This may be the initial study to report the prevalence of eno1, atl, and S1 serine protease genes in S. sobrinus from Iraqi patients.
Hanan khadm, Mithal Al-Hassani
doaj   +1 more source

Molecular characterization of the S1 gene in GI-17 and GI-13 type isolates of avian infectious bronchitis virus (IBV) in Costa Rica, from 2016 to 2019. [PDF]

Virusdisease, 2022
Villalobos-Agüero RA, León B, Zamora-Sanabria R, Karkashian-Córdoba J.   +3 more
europepmc   +1 more source

Evolutionary implications of genetic variations in the S1 gene of infectious bronchitis virus

Virus Research, 1994
The large number of phenotypically distinct strains of infectious bronchitis virus (IBV) provide a broad genetic background for examining naturally occurring coronavirus variation. Comparisons of the published nucleotide sequence of S1 genes of strains isolated in Europe, Japan and the USA and four additional American strains described in this report ...
Li, Wang, Junker, Dave, Hock, Lisa, Ebiary, Elham, Collisson, Ellen W.   +4 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source