Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. [PDF]
, 2018 GPR139 is an orphan G protein-coupled receptor (GPCR) that is expressed mainly in the brain, with the highest expression in the medial habenula. The modulation of GPR139 receptor function has been hypothesized to be beneficial in the treatment of some ...
Conlisk, Dana +5 more
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Blocking of flavor-nausea learning by non-flavor cues: assessment through orofacial reactivity responses [PDF]
, 2017 We investigated, using orofacial reactivity assessment, whether nonflavor context cues can elicit conditioned aversive reactions, and also whether context cues interfere, through blocking, with the reduction in taste palatability during taste aversion ...
Dwyer, Dominic M. +3 more
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Frontiers in Behavioral NeuroscienceIntroductionCertain events that occur in early life, such as changes in nutrition, can induce structural and functional modifications in brain development, leading to behavioral programing in the offspring.
Beatriz Pacheco-Sánchez +18 more
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Intra-nucleus accumbens shell injections of R(+)- and S(-)-baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice [PDF]
, 2014 The GABAB agonist baclofen has been widely researched clinically and preclinically as a treatment of alcohol use disorders (AUDs). However, the efficacy of baclofen remains uncertain.
Boehm II, Stephen L., Kasten, Chelsea R.
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How Can Network-Pharmacology Contribute to Antiepileptic Drug Development? [PDF]
, 2014 Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is
Di Ianni, Mauricio Emiliano +1 more
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Freiwillige Aufnahme von Kokain und Morphin im Tiermodell bei gemeinsamer und getrennter Darbietung sowie deren Beeinflussung durch eine vorangehende, erzwungene Aufnahme [PDF]
, 2004 Während der letzten Jahrzehnte finden Probleme des gleichzeitigen Mißbrauchs mehrerer psychoaktiver Drogen zunehmend Beachtung. Die vorliegende Arbeit geht der Frage nach, ob Drogen wie Morphin und Kokain in gleichem Maß als Belohnung empfundene ...
Schulze, Katrin +1 more
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Química Nova, 2008 In this work was developed a method for the determination of saccharin in dietary products by a biamperometric titration, using two silver electrodes as working electrodes and silver nitrate as titrant.
Mônica H. M. T. Assumpção +3 more
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Lentiviral vector-mediated dopamine D3 receptor modulation in the rat brain impairs alcohol intake and ethanol-induced conditioned place preference [PDF]
, 2014 Background: It has been reported that dopamine D3 receptor (D3R) knockout mice display similar ethanol (EtOH) consumption compared to wild types. In addition, studies with D3R pharmacological targeting were inconclusive.Methods: In the current study, we ...
Bahi, Amine, Dreyer, Jean-Luc
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Decrease of vanillin sucrose intake by victorious and defeated mice: development of anhedonia? [PDF]
, 2007 Hedonic reactions to various rewards play a key role in various forms of motivated behavior. The influence of repeated experience of social victories or defeats in daily agonistic interactions between male mice on voluntary consumption of vanillin ...
Damira F. Avgustinovich +3 more
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Comparative Evaluation of the Photostability of Carbamazepine Polymorphs and Cocrystals
Crystals, 2019 Carbamazepine (CBZ), a widely used antiepileptic, is known to be sensitive to light. The aim of this study was to evaluate the photostabilities of three cocrystals of CBZ (CBZ−succinic acid (SUC), CBZ−saccharin (SAC) form I, and CBZ−SAC
Reiko Yutani +7 more
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