Results 1 to 10 of about 710,140 (248)

Ultrasonic-assisted nanofiltration separation recovering salvianolic acid B from ethanol wastewater [PDF]

Ultrasonics Sonochemistry
The transformation of salvianolic acid B brought on by heat treatment recovery of ethanol eluent, which is a difficult problem in pharmaceutical technology, affects the purity of raw material when the medicinal raw material salvianolic acid B is purified
Cunyu Li, Yun Ma, Yangyang Xu, Ranyun Qiu, Xin Shen, Lulu Huang, Anrong Liu, Mingming Li, Yunfeng Zheng, Xinglei Zhi   +9 more
doaj   +5 more sources

Salvianolic acid B in fibrosis treatment: a comprehensive review [PDF]

Frontiers in Pharmacology
Fibrosis is a public health issue of great concern characterized by the excessive deposition of extracellular matrix, leading to the destruction of parenchymal tissue and organ dysfunction that places a heavy burden on the global healthcare system due to
Qingzhi Liang, Xiaoqin Liu, Xi Peng, Ting Luo, Yi Su, Xin Xu, Hongyan Xie, Hongyan Xie, Hongyan Xie, Hong Gao, Hong Gao, Hong Gao, Zhengtao Chen, Chunguang Xie, Chunguang Xie, Chunguang Xie   +15 more
doaj   +5 more sources

Salvianolic Acid B: A Review of Pharmacological Effects, Safety, Combination Therapy, New Dosage Forms, and Novel Drug Delivery Routes [PDF]

Pharmaceutics, 2023
Salvianolic acid B is extracted from the roots and rhizomes of Danshen (Salvia miltiorrhiza Bge., family Labiatae). It is a water-soluble, weakly acidic drug that has demonstrated antitumor and anti-inflammatory effects on various organs and tissues such
Guannan He, Guangfeng Chen, Weidong Liu, Dongxue Ye, Xuehuan Liu, Xiaodong Liang, Jing Song   +6 more
doaj   +3 more sources

Neuroprotective Effects of Geopung-Chunghyuldan Based on Its Salvianolic Acid B Content Using an In Vivo Stroke Model [PDF]

Current Issues in Molecular Biology, 2023
Background: Geopung-Chunghyuldan (GCD) has neuroprotective properties. Salviae miltiorrhizae Radix plays an essential role in GCD’s effect. The Salviae miltiorrhizae Radix marker compound is salvianolic acid B; however, its content is not uniform among ...
Han-Gyul Lee, Seungwon Kwon, Sang-Kwan Moon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Jung-Mi Park, Chang-Nam Ko, Ki-Ho Cho   +8 more
doaj   +2 more sources

Salvianolic acid B promotes angiogenesis and inhibits cardiomyocyte apoptosis by regulating autophagy in myocardial ischemia. [PDF]

Chin Med, 2023
Background Myocardial ischemia (MI) can cause angina, myocardial infarction, and even death. Angiogenesis is beneficial for ensuring oxygen and blood supply to ischemic tissue, promoting tissue repair, and reducing cell damage.
Chen Q, Xu Q, Zhu H, Wang J, Sun N, Bian H, Li Y, Lin C.   +7 more
europepmc   +2 more sources

Salvianolic acid B attenuates liver fibrosis by targeting Ecm1 and inhibiting hepatocyte ferroptosis. [PDF]

Redox Biol
Hepatocyte ferroptosis promotes the pathogenesis and progression of liver fibrosis. Salvianolic acid B (Sal B) exerts antifibrotic effects. However, the pharmacological mechanism and target has not yet been fully elucidated. In this study, liver fibrosis
Fu Y, Zhou X, Wang L, Fan W, Gao S, Zhang D, Ling Z, Zhang Y, Ma L, Bai F, Chen J, Sun B, Liu P.   +12 more
europepmc   +2 more sources

Safety, tolerance, and pharmacokinetics of salvianolic acid B in healthy Chinese volunteers: A randomized, double-blind, placebo-controlled phase 1 clinical trial

Frontiers in Pharmacology, 2023
Background: Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza Bunge. In China, many traditional Chinese medicines have been modified into injections for higher bioavailability and better efficacy.
Junlin Cheng, Jun Long, Jingjing Zhang, Le Han, Yunfang Hu, Jianghui Liu, Runze Qiu, Zhibin Zhu, Hongwei Fan   +8 more
doaj   +2 more sources

Salvianolic acid B ameliorates myocardial fibrosis in diabetic cardiomyopathy by deubiquitinating Smad7. [PDF]

Chin Med, 2023
Background Salvianolic acid B (Sal B), a water-soluble phenolic compound derived from Salvia miltiorrhiza Bunge, is commonly used in Traditional Chinese Medicine to treat cardiovascular disease.
Luo H, Fu L, Wang X, Yini Xu, Ling Tao, Shen X.   +5 more
europepmc   +2 more sources

Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment. [PDF]

Mater Today Bio
The therapeutic effect of immune checkpoint inhibitors (ICIs) in triple-negative breast cancer (TNBC) is unsatisfactory. The immune "cold" microenvironment caused by tumor-associated fibroblasts (TAFs) has an adverse effect on the antitumor response ...
Cheng N, Zhou Q, Jia Z, Mu Y, Zhang S, Wang L, Chen Y.   +6 more
europepmc   +2 more sources

Salvianolic acid B inhibits thrombosis and directly blocks the thrombin catalytic site. [PDF]

Res Pract Thromb Haemost
Background Salvianolic acid B (SAB) is a major component of Salvia miltiorrhiza root (Danshen), widely used in East/Southeast Asia for centuries to treat cardiovascular diseases.
Neves MAD, Ni TT, Mackeigan DT, Shoara AA, Lei X, Slavkovic S, Yu SY, Stratton TW, Gallant RC, Zhang D, Xu XR, Fernandes C, Zhu G, Hu X, Chazot N, Donaldson LW, Johnson PE, Connelly K, Rand M, Wang Y, Ni H.   +20 more
europepmc   +2 more sources