Results 131 to 140 of about 389,863 (313)

Positive Invariance for Linear Sampled-data Systems [PDF]

, 2017
: The sampled-data framework captures conventional sampled-data systems, and it also provides an adequate representational tool for contemporary cyber-physical and smart autonomous systems.
Fontes, Fernando A C C, Sasa V Rakovic
core  

Sampled-Data-Based Local Stability of Neutral Time-Delay Systems With Actuator Saturation

IEEE Access
In this work, the local stability issue of neutral delay system with actuator saturation under sampled-data controller is studied. Firstly, considering the influence of actuator saturation on the system, the sampled-data controller with variable sampling
Dapeng Li, Shuiqing Ye, Chao Ge
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Determining the intersample response of state feedback control systems using boundary value problems

Boundary Value Problems
This paper investigates intersample dynamics, a key aspect of sampled-data systems, as the controlled processes are usually physical systems. We present a novel, boundary value problem-based method to reconstruct the continuous-time response from the ...
Tamás Haba, Csaba Budai
doaj   +1 more source

Event-Triggered Sampled-Data Iterative Learning Control for Fractional-Order Cyber-Physical Systems

Fractal and Fractional
This paper investigates the output synchronization of fractional-order cyber-physical systems (FOCPSs) under communication constraints. To address limited bandwidth and high transmission costs, an event-triggered encoding-decoding sampled-data iterative ...
Jiajun Sun, Siyuan Wang, Xingyu Zhou, Xinsong Zhang, Chenghong Gu   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

New research directions in the area of sampled-data systems [PDF]

New research directions in the area of sampled-data systems. Increased application of digital technology in a wide variety of control engineering applications has led to renewed interest in the study of sampled-data systems.

core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source