Results 1 to 10 of about 6,019,041 (305)

Integrative bioinformatics, network toxicology, and molecular docking elucidate molecular mechanisms of ATBC-induced sarcoma progression with experimental validation [PDF]

BMC Pharmacology and Toxicology
Background Acetyl tributyl citrate (ATBC), a widely used plasticizer, has raised health concerns due to its potential environmental persistence and human exposure, but its toxicological effects on sarcoma remain unclear. Methods We employed an integrated
Yue Wang, Xuan Lin, Yihuang Chen, Yuanqun Zhang, Qiang Zhang, Miao Xu, Xiaoning Lin, Xin Wu, Shifu Peng, Jianlin Shen   +9 more
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Is Kaposi’s sarcoma the end of the OX40/OX40L axis in atopic dermatitis? [PDF]

Frontiers in Immunology
The OX40/OX40L axis entered clinical development in atopic dermatitis with a strong biological rationale and early signs of durable activity. However, as the treatment landscape evolved, questions emerged about whether the magnitude of monotherapy ...
Shahram Salek-Ardakani
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Focal adhesion kinase promotes biphasic differentiation and induces infiltration and metastasis of synovial sarcoma [PDF]

Journal of Translational Medicine
Background Synovial sarcoma is a malignant tumor of mesenchymal origin, which is characterized by the simultaneous expression of epithelia and mesenchyme. Tumor microenvironment plays an important role in the development of synovial sarcoma.
Ning Wang, Shuang-shuang Dong, Hui-fang Zhuo, Ming-wen Wang, Zhong-xu Xue, Zhong Li, Lian Meng, Yan Qi, Xianglin Yuan, Jianming Hu   +9 more
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Definitive Radiotherapy in the Management of Non-Resectable or Residual Retroperitoneal Sarcomas: Institutional Cohort Analysis and Systematic Review

Cancer Control, 2021
Background: There is currently no consensus on optimal management of patients with primary or recurrent non-resectable/residual retroperitoneal sarcomas (RPS). The objective of this study was to document the outcomes of patients with primary or recurrent
Aleksandra Sobiborowicz, Mateusz Jacek Spałek MD, PhD, Anna Małgorzata Czarnecka MD, PhD, MSc, Piotr Rutkowski MD, PhD   +3 more
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Ewing sarcoma genomics and recent therapeutic advancements

Pediatric Hematology Oncology Journal, 2023
Ewing sarcomas are highly heterogenous mesenchymal tumors that develop in bone or soft tissue and primarily affect children, teenagers, and young adults. After osteosarcoma, it is the second most common malignant bone sarcoma.
Manisha Chavan, Sandesh Dhakal, Ajay Singh, Vikramaditya Rai, Sanjiya Arora, Mohitha C Mallipeddi, Arghadip Das   +6 more
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Newly formated (tertiary) lymphoid structures in tumor growth [PDF]

Наука и инновации в медицине, 2022
Aim to reproduce tertiary lymphoid structures and study their features in a malignant neoplasm in the experiment. Material and methods. Male white rats of the Wistar stress-resistant line were inoculated with the tumor strain sarcoma M1.
Rasul A. Rustamkhanov, Shamil R. Kzyrgalin, Dauranbek T. Arybzhanov, Kamil Sh. Gantsev, Davlat S. Tursumetov, Shamil Kh. Gantsev   +5 more
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Construction of a prognostic signature in Ewing's sarcoma: Based on metabolism-related genes

Translational Oncology, 2021
Objective: By combining the expression profiles of metabolism-related genes (MRGS) with clinical information, the expression quantities of MRGS and the influence on development and prognosis were systematically analyzed, so as to provide a theoretical ...
Zhaoyu Fu, Bo Yu, Mingxi Liu, Bo Wu, Yuanyuan Hou, Hongyu Wang, Yuting Jiang, Dong Zhu   +7 more
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BRAF inhibition curtails IFN‐gamma‐inducible PD‐L1 expression and upregulates the immunoregulatory protein galectin‐1 in melanoma cells

Molecular Oncology, 2020
Although melanoma is considered one of the most immunogenic malignancies, spontaneous T‐cell responses to melanoma antigens are ineffective due to tumor cell‐intrinsic or microenvironment‐driven immune evasion mechanisms.
Patryk Górniak, Maja Wasylecka‐Juszczyńska, Iwona Ługowska, Piotr Rutkowski, Anna Polak, Maciej Szydłowski, Przemysław Juszczyński   +6 more
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Oxidative stress and histopathological changes in several organs of mice injected with biogenic silver nanoparticles

Artificial Cells, Nanomedicine, and Biotechnology, 2022
The widespread use of silver nanoparticles (AgNPs) requires a study of their safety. The aim of the present study was to assess the levels of oxidative stress markers and histopathological changes in the experimental model of sarcoma S-180 of outbred ...
Shushanik Kazaryan, Lilit Farsiyan, Juleta Tumoyan, Gayane Kirakosyan, Naira Ayvazyan, Hrachik Gasparyan, Sona Buloyan, Lilit Arshakyan, Ara Kirakosyan, Ashkhen Hovhannisyan   +9 more
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PATIENT-DERIVED XENOGRAFTS AS A PRECLINICAL MODEL FOR BONE SARCOMAS [PDF]

Acta Ortopédica Brasileira, 2018
Objective: The purpose of this study was to reproduce a mouse model of bone sarcomas for use in cancer research. Methods: A fresh sample of the tumor tissue was implanted subcutaneously into nude mice.
WALTER MEOHAS, REGINA ALCANTARA GRANATO, JOÃO ANTONIO MATHEUS GUIMARÃES, RHAYRA BRAGA DIAS, ANNELIESE FORTUNA-COSTA, MARIA EUGENIA LEITE DUARTE   +5 more
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