Results 11 to 20 of about 65,186 (354)
Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy. [PDF]
Gene, 2015 Background: Hypertrophic cardiomyopathy (HCM) is a common genetic heart disorder characterized by unexplained left ventricle hypertrophy associated with non-dilated ventricular chambers.
BOTTILLO, IRENE +12 more
core +5 more sources
Sarcomere Dysfunction in Nemaline Myopathy
Journal of Neuromuscular Diseases, 2017 Nemaline myopathy (NM) is among the most common non-dystrophic congenital myopathies (incidence 1:50.000). Hallmark features of NM are skeletal muscle weakness and the presence of nemaline bodies in the muscle fiber. The clinical phenotype of NM patients
Josine M de Winter, C. Ottenheijm
semanticscholar +6 more sources
The M-band: The underestimated part of the sarcomere [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020 The sarcomere is the basic unit of the myofibrils, which mediate skeletal and cardiac Muscle contraction. Two transverse structures, the Z-disc and the M-band, anchor the thin (actin and associated proteins) and thick (myosin and associated proteins) filaments to the elastic filament system composed of titin.
S. Lange +3 more
semanticscholar +8 more sources
Fluid flow in the sarcomere [PDF]
Archives of Biochemistry and Biophysics, 2021 A highly organized and densely packed lattice of molecular machinery within the sarcomeres of muscle cells powers contraction. Although many of the proteins that drive contraction have been studied extensively, the mechanical impact of fluid shearing within the lattice of molecular machinery has received minimal attention. It was recently proposed that
Sage A. Malingen +4 more
openaire +3 more sources
Sarcomeric versus Non-Sarcomeric HCM
Cardiogenetics, 2023 Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disorder and is characterized by left ventricular hypertrophy (LVH), which is unexplained by abnormal loading conditions. HCM is inherited as an autosomal dominant trait and, in about 40% of patients, the causal mutation is identified in genes encoding sarcomere proteins ...
Borrelli, Felice +8 more
openaire +3 more sources
Sarcomere Length Nonuniformity and Force Regulation in Myofibrils and Sarcomeres [PDF]
Biophysical Journal, 2020 The smallest contractile unit in striated muscles is the sarcomere. Although some of the classic features of contraction assume a uniform behavior of sarcomeres within myofibrils, the occurrence of sarcomere length nonuniformities has been well recognized for years, but it is yet not well understood. In the past years, there has been a great advance in
Felipe de Souza Leite, Dilson E. Rassier
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Sarcomere mechanics in striated muscles: from molecules to sarcomeres to cells. [PDF]
American Journal of Physiology-Cell Physiology, 2017 Muscle contraction is commonly associated with the cross-bridge and sliding filament theories, which have received strong support from experiments conducted over the years in different laboratories. However, there are studies that cannot be readily explained by the theories, showing 1) a plateau of the force-length relation extended beyond optimal ...
D. Rassier
semanticscholar +4 more sources
Active Viscoelasticity of Sarcomeres [PDF]
Frontiers in Robotics and AI, 2018 The perturbation response of muscle is important for the versatile, stable and agile control capabilities of animals. Muscle resists being stretched by developing forces in the passive tissues and in the active crossbridges. This review focuses on the active perturbation response of the sarcomere. The active response exhibits typical stress relaxation,
Khoi D. Nguyen +2 more
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Spontaneous sarcomere dynamics [PDF]
Chaos: An Interdisciplinary Journal of Nonlinear Science, 2010 Sarcomeres are the basic force generating units of striated muscles and consist of an interdigitating arrangement of actin and myosin filaments. While muscle contraction is usually triggered by neural signals, which eventually set myosin motors into motion, isolated sarcomeres can oscillate spontaneously between a contracted and a relaxed state.
Stefan Gunther, Karsten Kruse
openaire +5 more sources
Pathogenic Mechanisms of Hypertrophic Cardiomyopathy beyond Sarcomere Dysfunction
International Journal of Molecular Sciences, 2021 Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder, affecting 1 in 500 people in the general population. Although characterized by asymmetric left ventricular hypertrophy, cardiomyocyte disarray, and cardiac fibrosis ...
Chun Chou, M. Chin
semanticscholar +1 more source