Results 11 to 20 of about 42,993 (322)
Circulation: Heart Failure, 2021 Supplemental Digital Content is available in the text. Background: Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease. While ≈50% of patients with HCM carry a sarcomere gene mutation (sarcomere mutation-positive, HCMSMP), the ...
M. Schuldt +18 more
semanticscholar +1 more source
Sarcomere maturation: function acquisition, molecular mechanism, and interplay with other organelles
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2022 During postnatal cardiac development, cardiomyocytes mature and turn into adult ones. Hence, all cellular properties, including morphology, structure, physiology and metabolism, are changed. One of the most important aspects is the contractile apparatus,
Razan E. Ahmed +4 more
semanticscholar +1 more source
Sarcomere mutation negative hypertrophic cardiomyopathy is associated with ageing and obesity
Open Heart, 2021 Background Despite advances in our understanding of the genetic causes of hypertrophic cardiomyopathy (HCM), a large portion of this patient population do not carry sarcomere gene mutations when screened.
Alejandro E de Feria +2 more
doaj +1 more source
Muscle in Variable Gravity: “I Do Not Know Where I Am, But I Know What to Do”
Frontiers in Physiology, 2021 Purpose: Fascicle and sarcomere lengths are important predictors of muscle mechanical performance. However, their regulation during stretch-shortening cycle (SSC) activities in usual and challenging conditions is poorly understood.
Elena Monti +12 more
doaj +1 more source
bioRxiv, 2022 Sustained muscle contraction occurs through interactions between actin and myosin filaments within sarcomeres and requires a constant supply of adenosine triphosphate (ATP) from nearby mitochondria.
Prasanna Katti +8 more
semanticscholar +1 more source
Current Protocols, 2022 Sarcomeres are the structural units of the contractile apparatus in cardiac and skeletal muscle cells. Changes in sarcomere characteristics are indicative of changes in the sarcomeric proteins and function during development and disease.
J. Stein +9 more
semanticscholar +1 more source
Sarcomere Length Nonuniformity and Force Regulation in Myofibrils and Sarcomeres [PDF]
Biophysical Journal, 2020 The smallest contractile unit in striated muscles is the sarcomere. Although some of the classic features of contraction assume a uniform behavior of sarcomeres within myofibrils, the occurrence of sarcomere length nonuniformities has been well recognized for years, but it is yet not well understood. In the past years, there has been a great advance in
Felipe de Souza Leite, Dilson E. Rassier
openaire +2 more sources
Monitoring the maturation of the sarcomere network: a super-resolution microscopy-based approach
Cellular and Molecular Life Sciences, 2022 The in vitro generation of human cardiomyocytes derived from induced pluripotent stem cells (iPSC) is of great importance for cardiac disease modeling, drug-testing applications and for regenerative medicine.
A. Skorska +12 more
semanticscholar +1 more source
Molecular Changes in Prepubertal Left Ventricular Development Under Experimental Volume Overload
Frontiers in Cardiovascular Medicine, 2022 BackgroundLeft ventricular (LV) volume overload (VO), commonly found in patients with chronic aortic regurgitation (AR), leads to a series of left ventricular (LV) pathological responses and eventually irreversible LV dysfunction.
Yuqing Hu +16 more
doaj +1 more source
Circulation, 2020 Supplemental Digital Content is available in the text. Background: Hypertrophic cardiomyopathy (HCM) is caused by pathogenic variants in sarcomere protein genes that evoke hypercontractility, poor relaxation, and increased energy consumption by the heart
Christopher N Toepfer +27 more
semanticscholar +1 more source