Results 21 to 30 of about 65,186 (354)

Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2

Cell Reports, 2021
Summary: Actinins are strain-sensing actin cross-linkers that are ubiquitously expressed and harbor mutations in human diseases. We utilize CRISPR, pluripotent stem cells, and BioID to study actinin interactomes in human cardiomyocytes.
Feria A. Ladha, Ketan Thakar, Anthony M. Pettinato, Nicholas Legere, Shahnaz Ghahremani, Rachel Cohn, Robert Romano, Emily Meredith, Yu-Sheng Chen, J. Travis Hinson   +9 more
doaj   +1 more source

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Hypertrophic cardiomyopathy (HCM) is caused by pathogenic variants in sarcomere protein genes that evoke hypercontractility, poor relaxation, and increased energy consumption by the heart
Christopher N Toepfer, Amanda C Garfinkel, G. Venturini, H. Wakimoto, Giuliana G. Repetti, L. Alamo, Arun K. Sharma, Radhika Agarwal, Jourdan F Ewoldt, Paige E. Cloonan, Justin H. Letendre, M. Lun, I. Olivotto, S. Colan, E. Ashley, D. Jacoby, M. Michels, C. Redwood, H. Watkins, S. Day, J. F. Staples, R. Padrón, Anant Chopra, Carolyn Y. Ho, Christopher S. Chen, A. Pereira, J. Seidman, C. Seidman   +27 more
semanticscholar   +1 more source

Muscle growth by sarcomere divisions. [PDF]

Sci Adv
The sarcomere is the elementary contractile unit of muscles. Adult muscle cells are large and chain thousands of sarcomeres into long periodic myofibrils that attach to the skeleton. During development, muscle cells must increase in length to maintain the mechanical connection to the growing skeleton.
Rodier C, Estabrook ID, Chan EH, Rice G, Loreau V, Raunser S, Görlich D, Friedrich BM, Schnorrer F.   +8 more
europepmc   +3 more sources

The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy [PDF]

, 2008
Background: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies results from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2).
Ahmad, F, Banerjee, SK, Conner, DA, Huang, XN, Janczewski, AM, Keller, BB, Lage, ML, Mathier, MA, Moskowitz, IP, Perez-Atayde, AR, Rager, J, Saba, S, Seidman, CE, Seidman, JG, Shroff, SG, Smith, SH, Tinney, JP, Tobita, K   +17 more
core   +7 more sources

Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: implications for anthracycline cardiomyopathy. [PDF]

PLoS ONE, 2012
Doxorubicin (Adriamycin) is an effective anti-cancer drug, but its clinical usage is limited by a dose-dependent cardiotoxicity characterized by widespread sarcomere disarray and loss of myofilaments.
Billy Chen, Lin Zhong, Sarah F Roush, Laura Pentassuglia, Xuyang Peng, Susan Samaras, Jeffrey M Davidson, Douglas B Sawyer, Chee Chew Lim   +8 more
doaj   +1 more source

Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

eLife, 2023
Palladin (PALLD) belongs to the PALLD/myopalladin (MYPN)/myotilin family of actin-associated immunoglobulin-containing proteins in the sarcomeric Z-line.
Giuseppina Mastrototaro, Pierluigi Carullo, Jianlin Zhang, Beatrice Scellini, Nicoletta Piroddi, Simona Nemska, Maria Carmela Filomena, Simone Serio, Carol A Otey, Chiara Tesi, Fabian Emrich, Wolfgang A Linke, Corrado Poggesi, Simona Boncompagni, Marie-Louise Bang   +14 more
doaj   +1 more source

Targets for therapy in sarcomeric cardiomyopathies [PDF]

Cardiovascular Research, 2015
To date, no compounds or interventions exist that treat or prevent sarcomeric cardiomyopathies. Established therapies currently improve the outcome, but novel therapies may be able to more fundamentally affect the disease process and course. Investigations of the pathomechanisms are generating molecular insights that can be useful for the design of ...
Tardiff JC, Carrier L, Bers DM, POGGESI, CORRADO, FERRANTINI, CECILIA, COPPINI, RAFFAELE, Maier LS, Ashrafian H, Huke S, van der Velden J.   +9 more
openaire   +7 more sources

Molecular Changes in Prepubertal Left Ventricular Development Under Experimental Volume Overload

Frontiers in Cardiovascular Medicine, 2022
BackgroundLeft ventricular (LV) volume overload (VO), commonly found in patients with chronic aortic regurgitation (AR), leads to a series of left ventricular (LV) pathological responses and eventually irreversible LV dysfunction.
Yuqing Hu, Debao Li, Chunxia Zhou, Yingying Xiao, Sijuan Sun, Chuan Jiang, Chuan Jiang, Chuan Jiang, Lijun Chen, Jinfen Liu, Hao Zhang, Hao Zhang, Fen Li, Haifa Hong, Lincai Ye, Lincai Ye, Lincai Ye   +16 more
doaj   +1 more source

Signalling in sarcomeres in development and disease [PDF]

Netherlands Heart Journal, 2013
Sarcomeres are the smallest contractile units of heart and skeletal muscles and are essential for generation and propagation of mechanical force in these striated muscles. During the last decades it has become increasingly clear that components of sarcomeres also play a fundamental role in signal transduction in physiological and pathophysiological ...
Robert Passier, Robert Passier, W. van Eldik   +2 more
openaire   +3 more sources

Revisiting Frank–Starling: regulatory light chain phosphorylation alters the rate of force redevelopment (ktr) in a length-dependent fashion [PDF]

, 2016
Force and power in cardiac muscle have a known dependence on phosphorylation of the myosin-associated regulatory light chain (RLC). We explore the effect of RLC phosphorylation on the ability of cardiac preparations to redevelop force (ktr ) in maximally
Abraham, Adhikari, Aoki, Araujo, Barany, Blue, Bremel, Brenner, Brenner, Colson, Curtin, Davis, Ding, Ferenczi, Fitzsimons, Greenberg, Greenberg, Gu, Guccione, Hanft, Hanft, He, Hidalgo, Hooijman, Huang, Huxley, Huxley, Ishijima, Karabina, Katz, Kentish, Korte, Levine, Mansfield, Metzger, Milani-Nejad, Morano, Morano, Moss, Muthu, Nag, Nishio, Nyitrai, Okamoto, Olsson, Pate, Patel, Podolsky, Prakash, Prakash, Pulcastro, Regnier, Regnier, Regnier, Rhodes, Sanbe, Scruggs, Sheikh, Sheikh, Sonnenblick, Stelzer, Stelzer, Stracher, Sweeney, Takagi, Toepfer, Tombe, Tombe, Ueno, Wang, Warren, Wolff, Yuan   +72 more
core   +1 more source