Results 31 to 40 of about 42,993 (322)
Cell Reports, 2021 Summary: Actinins are strain-sensing actin cross-linkers that are ubiquitously expressed and harbor mutations in human diseases. We utilize CRISPR, pluripotent stem cells, and BioID to study actinin interactomes in human cardiomyocytes.
Feria A. Ladha +9 more
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Sarcomere and Inter-Sarcomere Dynamics within Skeletal Muscle Myofibrils [PDF]
Biophysical Journal, 2017 Introduction: Inter-sarcomere dynamics within muscle myofibrils underlie basic mechanisms of contraction. In this study, we used microfluidic perfusions to control the environment of sarcomeres within isolated myofibrils to directly investigate inter-sarcomere dynamics.
Felipe de Souza Leite, Dilson E. Rassier
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Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia
Cell Reports, 2019 Summary: Precise assembly of the sarcomere, a force-generating unit in striated muscles, is critical for muscle contraction. Defective sarcomere organization is linked to myopathies and cachexia. The molecular mechanisms concerning sarcomere assembly are
Arnab Nayak +5 more
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eLife, 2023 Palladin (PALLD) belongs to the PALLD/myopalladin (MYPN)/myotilin family of actin-associated immunoglobulin-containing proteins in the sarcomeric Z-line.
Giuseppina Mastrototaro +14 more
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Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes
eLife, 2018 The sarcomere is the contractile unit within cardiomyocytes driving heart muscle contraction. We sought to test the mechanisms regulating actin and myosin filament assembly during sarcomere formation.
Aidan M Fenix +15 more
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Molecular-scale visualization of sarcomere contraction within native cardiomyocytes
Nature Communications, 2020 Sarcomeres, the basic contractile units of striated muscle, produce the forces driving muscular contraction through cross-bridge interactions between actin-containing thin filaments and myosin II-based thick filaments.
L. Burbaum +7 more
semanticscholar +1 more source
Fluid flow in the sarcomere [PDF]
Archives of Biochemistry and Biophysics, 2021 A highly organized and densely packed lattice of molecular machinery within the sarcomeres of muscle cells powers contraction. Although many of the proteins that drive contraction have been studied extensively, the mechanical impact of fluid shearing within the lattice of molecular machinery has received minimal attention. It was recently proposed that
Sage A. Malingen +4 more
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Cell Reports, 2021 Summary: Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using ...
Anthony M. Pettinato +15 more
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The sarcomere force–length relationship in an intact muscle–tendon unit
Journal of Experimental Biology, 2020 The periodic striation pattern in skeletal muscle reflects the length of the basic contractile unit: the sarcomere. More than half a century ago, Gordon, Huxley and Julian provided strong support for the ‘sliding filament’ theory through experiments with
E. Moo, T. Leonard, W. Herzog
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Frontiers in Cell and Developmental Biology, 2021 Lifeact-GFP is a frequently used molecular probe to study F-actin structure and dynamic assembly in living cells. In this study, we generated transgenic zebrafish models expressing Lifeact-GFP specifically in cardiac muscles to investigate the effect of ...
Rui Xu, Shaojun Du
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