Results 31 to 40 of about 65,186 (354)

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

eLife, 2022
Human muscle is a hierarchically organised tissue with its contractile cells called myofibers packed into large myofiber bundles. Each myofiber contains periodic myofibrils built by hundreds of contractile sarcomeres that generate large mechanical forces.
Qiyan Mao, Achyuth Acharya, Alejandra Rodríguez-delaRosa, Fabio Marchiano, Benoit Dehapiot, Ziad Al Tanoury, Jyoti Rao, Margarete Díaz-Cuadros, Arian Mansur, Erica Wagner, Claire Chardes, Vandana Gupta, Pierre-François Lenne, Bianca H Habermann, Olivier Theodoly, Olivier Pourquié, Frank Schnorrer   +16 more
doaj   +1 more source

The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes. [PDF]

, 2017
Altered Ca2+ handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. However, whether Ca2+ directly regulates sarcomere structure has remained elusive.
Chen, Jau-Nian, Geisler, Robert, Huang, Jie, Langenbacher, Adam D, Otto, Georg, Shimizu, Hirohito, Wang, Kevin, Wang, Yibin   +7 more
core   +3 more sources

Distorting the sarcomere [PDF]

Journal of General Physiology, 2010
One of the goals of cardiovascular science is to create a mathematical model of the heart that can predict ventricular function in healthy and diseased states, and that can be used to help improve treatment options for patients with heart disease. To be clinically useful, the model will have to include structural information about the shapes of the ...
openaire   +3 more sources

Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities

Scientific Reports, 2020
When a muscle is stretched during a contraction, the resulting steady-state force is higher than the isometric force produced at a comparable sarcomere length.
Ricarda M. Haeger, Dilson E. Rassier
doaj   +1 more source

Molecular-scale visualization of sarcomere contraction within native cardiomyocytes

Nature Communications, 2020
Sarcomeres, the basic contractile units of striated muscle, produce the forces driving muscular contraction through cross-bridge interactions between actin-containing thin filaments and myosin II-based thick filaments.
L. Burbaum, J. Schneider, S. Scholze, R. Böttcher, W. Baumeister, P. Schwille, J. Plitzko, M. Jasnin   +7 more
semanticscholar   +1 more source

Foci of segmentally contracted sarcomeres in trapezius muscle biopsy specimens in myalgic and nonmyalgic human subjects : preliminary results [PDF]

, 2020
Objective The myofascial trigger point hypothesis postulates that there are small foci of contracted sarcomeres in resting skeletal muscle. Only one example, in canine muscle, has been published previously.
Cagnie, Barbara, Calders, Patrick, De Meulemeester, Kayleigh, Gerwin, Robert D., Petrovic, Mirko, Van Dorpe, Jo   +5 more
core   +1 more source

Research priorities in sarcomeric cardiomyopathies [PDF]

Cardiovascular Research, 2015
The clinical variability in patients with sarcomeric cardiomyopathies is striking: a mutation causes cardiomyopathy in one individual, while the identical mutation is harmless in a family member. Moreover, the clinical phenotype varies ranging from asymmetric hypertrophy to severe dilatation of the heart. Identification of a single phenotype-associated
Van Der Velden J., Ho C. Y., Tardiff J. C., Olivotto I., Knollmann B. C., Carrier L.   +5 more
openaire   +5 more sources

Volume overload impedes the maturation of sarcomeres and T-tubules in the right atria: a potential cause of atrial arrhythmia following delayed atrial septal defect closure

Frontiers in Physiology, 2023
Introduction: Adult patients with atrial septal defects (ASD), the most common form of adult congenital heart disease, often die of arrhythmias, and the immaturity of cardiomyocytes contributes significantly to arrhythmias.
Zhuoya Dong, Dian Chen, Sixie Zheng, Zheng Wang, Debao Li, Yingying Xiao, Sijuan Sun, Lincai Ye, Lincai Ye, Lincai Ye, Lisheng Qiu, Yuqing Hu, Haifa Hong, Haifa Hong   +13 more
doaj   +1 more source

Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans [PDF]

, 2017
The mouse is one of the most widely used animal models to study neuromuscular diseases and test new therapeutic strategies. However, findings from successful pre-clinical studies using mouse models frequently fail to translate to humans due to various ...
A De Luca, A Rajagopal, A Soman, AA Biewener, AA Biewener, AC Ludolph, AEH Emery, AL Camp, AV Birn-Jeffery, BH Wokke, BJ Petrof, C Pastoret, C Webster, CM Consolino, CM Eng, DM Escolar, E Azizi, E Mok, EK Moo, EM Arnold, EM Arnold, EM Arnold, FA Jenkins, FE Zajac, GM Buyse, GT Carter, H Radley-Crabb, H Stedman, HB van der Worp, HM Hsieh-Li, IG Kirkinezos, J Manning, JA Granchelli, JA Vilensky, JH Veldink, JJ Kaczor, JK Mah, JN Kornegay, JN Kornegay, JP Charles, JP Charles, JR Chamberlain, JW Carnwath, JW McGreevy, KA Clarke, KN An, L Xu, LM Ittner, M Benatar, M Bodor, M Millard, MD Grounds, MD Klein Horsman, ME Gurney, ME Llewellyn, MP Kadaba, N Alexander, N Serradj, NP Whitehead, P DeVita, P Moens, P Sicinski, R Burdi, R Willmann, R Willmann, RH Miller, RW Burgess, SL Delp, SL Delp, SR Ward, SS Blemker, SV Brooks, T Akay, TA McMahon, TA Partridge, TS Buchanan, V Brussee, VC Henderson, X Chen, X Chen, X Hu, ZJ Domire   +81 more
core   +2 more sources

Myomesin is part of an integrity pathway that responds to sarcomere damage and disease.

PLoS ONE, 2019
The structure and function of the sarcomere of striated muscle is well studied but the steps of sarcomere assembly and maintenance remain under-characterized.
Kendal Prill, Casey Carlisle, Megan Stannard, Pamela J Windsor Reid, David B Pilgrim   +4 more
doaj   +1 more source