Results 41 to 50 of about 42,993 (322)

Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients

Scientific Reports, 2020
The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients ...
Yuanyuan Dai, Asset Amenov, Nadezda Ignatyeva, A. Koschinski, Hang Xu, P. Soong, M. Tiburcy, W. Linke, M. Zaccolo, G. Hasenfuss, W. Zimmermann, A. Ebert   +11 more
semanticscholar   +1 more source

Advances in the Genetic Basis and Pathogenesis of Sarcomere Cardiomyopathies.

Annual review of genomics and human genetics (Print), 2019
Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are common heart muscle disorders that are caused by pathogenic variants in sarcomere protein genes.
R. Yotti, C. Seidman, J. Seidman
semanticscholar   +1 more source

Serial sarcomere number is substantially decreased within the paretic biceps brachii in individuals with chronic hemiparetic stroke

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Serial sarcomere number determines a muscle’s length during maximum force production and its available length range for active force generation.
Amy N Adkins, J. Dewald, L. Garmirian, Christa M. Nelson, W. Murray   +4 more
semanticscholar   +1 more source

Study of the Warner-Bratzler Shear Force, Sensory Analysis and Sarcomere Length as Indicators of the Tenderness of Sun-Dried Beef

Molecules, 2013
Sun-dried beef is a frequently consumed and valued product in Brazil, however, there have been no scientific studies on its texture. To assess the tenderness of sun-dried beef, an instrumental analysis (Warner-Bratzler Shear Force; WBSF), a sensory ...
Marta Madruga, Geany de Souza, Ricardo Moreira, Yuri Ishihara, Alanne Salviano   +4 more
doaj   +1 more source

Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers

Molecular Genetics & Genomic Medicine, 2020
Background A causal genetic mutation is found in 40% of families with dilated cardiomyopathy (DCM), leaving a large percentage of families genetically unsolved. This prevents adequate counseling and clear recommendations in these families.
Job A. J. Verdonschot, Emma L. Robinson, Kiely N. James, Mohamed W. Mohamed, Godelieve R. F. Claes, Kari Casas, Els K. Vanhoutte, Mark R. Hazebroek, Gabriel Kringlen, Michele M. Pasierb, Arthur van denWijngaard, Jan F. C. Glatz, Stephane R. B. Heymans, Ingrid P. C. Krapels, Shareef Nahas, Han G. Brunner, Radek Szklarczyk   +16 more
doaj   +1 more source

Biomechanical Properties of Paraspinal Muscles Influence Spinal Loading—A Musculoskeletal Simulation Study

Frontiers in Bioengineering and Biotechnology, 2022
Paraspinal muscles are vital to the functioning of the spine. Changes in muscle physiological cross-sectional area significantly affect spinal loading, but the importance of other muscle biomechanical properties remains unclear.
Masoud Malakoutian, Masoud Malakoutian, C. Antonio Sanchez, Stephen H. M. Brown, John Street, John Street, Sidney Fels, Thomas R. Oxland, Thomas R. Oxland, Thomas R. Oxland   +9 more
doaj   +1 more source

Metformin Protects against Diabetic Cardiomyopathy: An Association between Desmin–Sarcomere Injury and the iNOS/mTOR/TIMP-1 Fibrosis Axis

Biomedicines, 2022
The intermediate filament protein desmin is essential for maintaining the structural integrity of sarcomeres, the fundamental unit of cardiac muscle. Diabetes mellitus (DM) can cause desmin to become dysregulated, following episodes of nitrosative stress,
Amal F. Dawood, Norah M. Alzamil, Peter W. Hewett, Maha A. Momenah, Mohammad Dallak, Samaa S. Kamar, Dina H. Abdel Kader, Hanaa Yassin, Mohamed A. Haidara, Amro Maarouf, Bahjat Al-Ani   +10 more
doaj   +1 more source

Assembly and Maintenance of Sarcomere Thin Filaments and Associated Diseases

International Journal of Molecular Sciences, 2020
Sarcomere assembly and maintenance are essential physiological processes required for cardiac and skeletal muscle function and organism mobility. Over decades of research, components of the sarcomere and factors involved in the formation and maintenance ...
K. Prill, J. F. Dawson
semanticscholar   +1 more source

An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish

eLife, 2015
Truncating mutations in the giant sarcomeric protein Titin result in dilated cardiomyopathy and skeletal myopathy. The most severely affected dilated cardiomyopathy patients harbor Titin truncations in the C-terminal two-thirds of the protein, suggesting
Jun Zou, Diana Tran, Mai Baalbaki, Ling Fung Tang, Annie Poon, Angelo Pelonero, Erron W Titus, Christiana Yuan, Chenxu Shi, Shruthi Patchava, Elizabeth Halper, Jasmine Garg, Irina Movsesyan, Chaoying Yin, Roland Wu, Lisa D Wilsbacher, Jiandong Liu, Ronald L Hager, Shaun R Coughlin, Martin Jinek, Clive R Pullinger, John P Kane, Daniel O Hart, Pui-Yan Kwok, Rahul C Deo   +24 more
doaj   +1 more source

Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review

Cells, 2020
The maintenance of skeletal muscle mass plays a critical role in health and quality of life. One of the most potent regulators of skeletal muscle mass is mechanical loading, and numerous studies have led to a reasonably clear understanding of the ...
Kent W. Jorgenson, Stuart M. Phillips, Troy A. Hornberger   +2 more
doaj   +1 more source