Results 41 to 50 of about 65,186 (354)
Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia
Cell Reports, 2019 Summary: Precise assembly of the sarcomere, a force-generating unit in striated muscles, is critical for muscle contraction. Defective sarcomere organization is linked to myopathies and cachexia. The molecular mechanisms concerning sarcomere assembly are
Arnab Nayak +5 more
doaj +1 more source
Synergistic Model of Cardiac Function with a Heart Assist Device [PDF]
, 2019 The breakdown of cardiac self-organization leads to heart diseases and failure, the number one cause of death worldwide. The left ventricular pressure–volume relation plays a key role in the diagnosis and treatment of heart diseases.
Bestel, Haken, Knudsen, Simaan, Tuzun
core +2 more sources
Breaking sarcomeres by in vitro exercise [PDF]
Scientific Reports, 2016 AbstractEccentric exercise leads to focal disruptions in the myofibrils, referred to as “lesions”. These structures are thought to contribute to the post-exercise muscle weakness and to represent areas of mechanical damage and/or remodelling. Lesions have been investigated in human biopsies and animal samples after exercise. However, this approach does
Markus P. O. Gödderz +7 more
openaire +2 more sources
The sarcomere force–length relationship in an intact muscle–tendon unit
Journal of Experimental Biology, 2020 The periodic striation pattern in skeletal muscle reflects the length of the basic contractile unit: the sarcomere. More than half a century ago, Gordon, Huxley and Julian provided strong support for the ‘sliding filament’ theory through experiments with
E. Moo, T. Leonard, W. Herzog
semanticscholar +1 more source
Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes
eLife, 2018 The sarcomere is the contractile unit within cardiomyocytes driving heart muscle contraction. We sought to test the mechanisms regulating actin and myosin filament assembly during sarcomere formation.
Aidan M Fenix +15 more
doaj +1 more source
Scientific Reports, 2020 The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients ...
Yuanyuan Dai +11 more
semanticscholar +1 more source
Influence of temperature on the calcium sensitivity of the myofilaments of skinned ventricular muscle from the rabbit. [PDF]
, 1989 The steady-state myofilament Ca sensitivity was determined in skinned cardiac trabeculae from the rabbit right ventricle (diameter, 0.13-0.34 mm) at 36, 29, 22, 15, 8, and 1 degree C.
Bers, DM, Harrison, SM
core +3 more sources
On the mechanics of single sarcomeres.
Molecular & cellular biomechanics : MCB, 2010 This article has no abstract.
Walter Herzog, Tim Leonard, Joumaa
openaire +3 more sources
Cell Reports, 2021 Summary: Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using ...
Anthony M. Pettinato +15 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Serial sarcomere number determines a muscle’s length during maximum force production and its available length range for active force generation.
Amy N Adkins +4 more
semanticscholar +1 more source