Results 51 to 60 of about 42,993 (322)

An optimized approach to study nanoscale sarcomere structure utilizing super-resolution microscopy with nanobodies.

PLoS ONE
The sarcomere is the fundamental contractile unit in skeletal muscle, and the regularity of its structure is critical for function. Emerging data demonstrates that nanoscale changes to the regularity of sarcomere structure can affect the overall function
Collin M Douglas, Jonathan E Bird, Daniel Kopinke, Karyn A Esser   +3 more
doaj   +1 more source

Frequency-dependent signaling in cardiac myocytes

Frontiers in Physiology, 2022
Background: Recent experimental data support the view that signaling activity at the membrane depends on its geometric parameters such as surface area and curvature.
Payam Haftbaradaran Esfahani, Jan Westergren, Lennart Lindfors, Ralph Knöll, Ralph Knöll   +4 more
doaj   +1 more source

Gaining new understanding of sarcomere length non-uniformities in skeletal muscles

Frontiers in Physiology
Sarcomere lengths are non-uniform on all structural levels of mammalian skeletal muscle. These non-uniformities have been associated with a variety of mechanical properties, including residual force enhancement and depression, creep, increased force ...
Meng Li, T. R. Leonard, S. W. Han, E. K. Moo, E. K. Moo, E. K. Moo, W. Herzog   +6 more
doaj   +1 more source

The sarcomeric cytoskeleton: from molecules to motion [PDF]

Journal of Experimental Biology, 2016
ABSTRACT Highly ordered organisation of striated muscle is the prerequisite for the fast and unidirectional development of force and motion during heart and skeletal muscle contraction. A group of proteins, summarised as the sarcomeric cytoskeleton, is essential for the ordered assembly of actin and myosin filaments into sarcomeres, by ...
Gautel, Mathias, Djinović-Carugo, Kristina   +1 more
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation

eLife
Styxl2, a poorly characterized pseudophosphatase, was identified as a transcriptional target of the Jak1-Stat1 pathway during myoblast differentiation in culture. Styxl2 is specifically expressed in vertebrate striated muscles.
Xianwei Chen, Yanfeng Li, Jin Xu, Yong Cui, Qian Wu, Haidi Yin, Yuying Li, Chuan Gao, Liwen Jiang, Huating Wang, Zilong Wen, Zhongping Yao, Zhenguo Wu   +12 more
doaj   +1 more source

Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki, Satoru Noguchi, Hotake Takizawa, Yasushi Oya, Yuji Takahashi, Hirofumi Komaki, Hajime Arahata, Shinichiro Hayashi, Ichizo Nishino   +8 more
wiley   +1 more source

Characterization of Gelatin Hydrogels Cross-Linked with Microbial Transglutaminase as Engineered Skeletal Muscle Substrates

Bioengineering, 2021
Engineered in vitro models of skeletal muscle are essential for efficiently screening drug safety and efficacy. However, conventional culture substrates poorly replicate physical features of native muscle and do not support long-term culture, which ...
Divya Gupta, Jeffrey W. Santoso, Megan L. McCain   +2 more
doaj   +1 more source

Research priorities in sarcomeric cardiomyopathies [PDF]

Cardiovascular Research, 2015
The clinical variability in patients with sarcomeric cardiomyopathies is striking: a mutation causes cardiomyopathy in one individual, while the identical mutation is harmless in a family member. Moreover, the clinical phenotype varies ranging from asymmetric hypertrophy to severe dilatation of the heart. Identification of a single phenotype-associated
Van Der Velden J., Ho C. Y., Tardiff J. C., Olivotto I., Knollmann B. C., Carrier L.   +5 more
openaire   +4 more sources

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source