Results 51 to 60 of about 65,186 (354)
Left ventricular active stiffness: dependency on time and inotropic state [PDF]
, 1978 Left ventricular systolic stiffness was measured by rapidly changing ventricular volume (within 7 ms) of isovolumically contracting isolated rabbit hearts. Instantaneous pressure-volume relations were found to be linear with slopes that depended upon the
Boom, Herman B.K., Schiereck, Piet
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Dynamic behaviour of half‐sarcomeres during and after stretch in activated rabbit psoas myofibrils: sarcomere asymmetry but no ‘sarcomere popping’ [PDF]
The Journal of Physiology, 2006 We examined length changes of individual half‐sarcomeres during and after stretch in actively contracting, single rabbit psoas myofibrils containing 10–30 sarcomeres. The myofibrils were fluorescently immunostained so that both Z‐lines and M‐bands of sarcomeres could be monitored by video microscopy simultaneously with the force measurement.
Gabriele Pfitzer +5 more
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Frontiers in Cell and Developmental Biology, 2021 Lifeact-GFP is a frequently used molecular probe to study F-actin structure and dynamic assembly in living cells. In this study, we generated transgenic zebrafish models expressing Lifeact-GFP specifically in cardiac muscles to investigate the effect of ...
Rui Xu, Shaojun Du
doaj +1 more source
Advances in the Genetic Basis and Pathogenesis of Sarcomere Cardiomyopathies.
Annual review of genomics and human genetics (Print), 2019 Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are common heart muscle disorders that are caused by pathogenic variants in sarcomere protein genes.
R. Yotti, C. Seidman, J. Seidman
semanticscholar +1 more source
Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy. [PDF]
, 2014 BACKGROUND: Sarcomere protein mutations in hypertrophic cardiomyopathy induce subtle cardiac structural changes before the development of left ventricular hypertrophy (LVH).
Bassett, P +18 more
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Assembly and Maintenance of Sarcomere Thin Filaments and Associated Diseases
International Journal of Molecular Sciences, 2020 Sarcomere assembly and maintenance are essential physiological processes required for cardiac and skeletal muscle function and organism mobility. Over decades of research, components of the sarcomere and factors involved in the formation and maintenance ...
K. Prill, J. F. Dawson
semanticscholar +1 more source
Molecular Genetics & Genomic Medicine, 2020 Background A causal genetic mutation is found in 40% of families with dilated cardiomyopathy (DCM), leaving a large percentage of families genetically unsolved. This prevents adequate counseling and clear recommendations in these families.
Job A. J. Verdonschot +16 more
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Mechanosensing in myosin filament solves a 60 years old conflict in skeletal muscle modeling between high power output and slow rise in tension [PDF]
, 2016 Almost 60 years ago Andrew Huxley with his seminal paper \cite{Huxley1957} laid the foundation of modern muscle modeling, linking chemical events to mechanical performance.
Marcucci, Lorenzo, Reggiani, Carlo
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Frontiers in Bioengineering and Biotechnology, 2022 Paraspinal muscles are vital to the functioning of the spine. Changes in muscle physiological cross-sectional area significantly affect spinal loading, but the importance of other muscle biomechanical properties remains unclear.
Masoud Malakoutian +9 more
doaj +1 more source
The sarcomeric cytoskeleton: from molecules to motion [PDF]
Journal of Experimental Biology, 2016 ABSTRACT Highly ordered organisation of striated muscle is the prerequisite for the fast and unidirectional development of force and motion during heart and skeletal muscle contraction. A group of proteins, summarised as the sarcomeric cytoskeleton, is essential for the ordered assembly of actin and myosin filaments into sarcomeres, by ...
Kristina Djinović-Carugo +2 more
openaire +5 more sources