Results 71 to 80 of about 65,186 (354)

Magnetic susceptibility anisotropy of myocardium imaged by cardiovascular magnetic resonance reflects the anisotropy of myocardial filament α-helix polypeptide bonds. [PDF]

, 2015
BackgroundA key component of evaluating myocardial tissue function is the assessment of myofiber organization and structure. Studies suggest that striated muscle fibers are magnetically anisotropic, which, if measurable in the heart, may provide a tool ...
Dibb, Russell, Liu, Chunlei, Qi, Yi
core   +1 more source

An optimized approach to study nanoscale sarcomere structure utilizing super-resolution microscopy with nanobodies.

PLoS ONE
The sarcomere is the fundamental contractile unit in skeletal muscle, and the regularity of its structure is critical for function. Emerging data demonstrates that nanoscale changes to the regularity of sarcomere structure can affect the overall function
Collin M Douglas, Jonathan E Bird, Daniel Kopinke, Karyn A Esser   +3 more
doaj   +1 more source

Frequency-dependent signaling in cardiac myocytes

Frontiers in Physiology, 2022
Background: Recent experimental data support the view that signaling activity at the membrane depends on its geometric parameters such as surface area and curvature.
Payam Haftbaradaran Esfahani, Jan Westergren, Lennart Lindfors, Ralph Knöll, Ralph Knöll   +4 more
doaj   +1 more source

Gaining new understanding of sarcomere length non-uniformities in skeletal muscles

Frontiers in Physiology
Sarcomere lengths are non-uniform on all structural levels of mammalian skeletal muscle. These non-uniformities have been associated with a variety of mechanical properties, including residual force enhancement and depression, creep, increased force ...
Meng Li, T. R. Leonard, S. W. Han, E. K. Moo, E. K. Moo, E. K. Moo, W. Herzog   +6 more
doaj   +1 more source

An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish

eLife, 2015
Truncating mutations in the giant sarcomeric protein Titin result in dilated cardiomyopathy and skeletal myopathy. The most severely affected dilated cardiomyopathy patients harbor Titin truncations in the C-terminal two-thirds of the protein, suggesting
Jun Zou, Diana Tran, Mai Baalbaki, Ling Fung Tang, Annie Poon, Angelo Pelonero, Erron W Titus, Christiana Yuan, Chenxu Shi, Shruthi Patchava, Elizabeth Halper, Jasmine Garg, Irina Movsesyan, Chaoying Yin, Roland Wu, Lisa D Wilsbacher, Jiandong Liu, Ronald L Hager, Shaun R Coughlin, Martin Jinek, Clive R Pullinger, John P Kane, Daniel O Hart, Pui-Yan Kwok, Rahul C Deo   +24 more
doaj   +1 more source

Formin’ muscle sarcomeres [PDF]

Journal of Cell Biology, 2012
![Figure][1] Actin filaments (magenta) show a striated pattern in wild-type body wall muscle cells (left) but are disorganized in cells lacking CYK-1 (right). Mi-Mi et al. describe two actin-nucleating proteins that assemble actin filaments into the sarcomeres of worm muscle cells ...
openaire   +2 more sources

Redox Signaling and Cardiac Sarcomeres [PDF]

Journal of Biological Chemistry, 2011
Oxidative stress is common in many clinically important cardiac disorders, including ischemia/reperfusion, diabetes, and hypertensive heart disease. Oxidative stress leads to derangements in pump function due to changes in the expression or function of proteins that regulate intracellular Ca(2+) homeostasis.
Marius P. Sumandea, Susan F. Steinberg
openaire   +3 more sources

Cronos Titin is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function.

Circulation, 2019
Background: The giant sarcomere protein titin is important in both heart health and disease. Mutations in the gene encoding for titin, TTN, are the leading known cause of familial dilated cardiomyopathy.
R. Zaunbrecher, Ashley Abel, Kevin M. Beussman, Andrea Leonard, Marion von Frieling-Salewsky, P. Fields, Lil Pabon, H. Reinecke, Xiulan Yang, J. Macadangdang, Deok‐Ho Kim, W. Linke, N. Sniadecki, Michael Regnier, C. Murry   +14 more
semanticscholar   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation

eLife
Styxl2, a poorly characterized pseudophosphatase, was identified as a transcriptional target of the Jak1-Stat1 pathway during myoblast differentiation in culture. Styxl2 is specifically expressed in vertebrate striated muscles.
Xianwei Chen, Yanfeng Li, Jin Xu, Yong Cui, Qian Wu, Haidi Yin, Yuying Li, Chuan Gao, Liwen Jiang, Huating Wang, Zilong Wen, Zhongping Yao, Zhenguo Wu   +12 more
doaj   +1 more source