Results 41 to 50 of about 16,570 (272)
Research priorities in sarcomeric cardiomyopathies [PDF]
Cardiovascular Research, 2015 The clinical variability in patients with sarcomeric cardiomyopathies is striking: a mutation causes cardiomyopathy in one individual, while the identical mutation is harmless in a family member. Moreover, the clinical phenotype varies ranging from asymmetric hypertrophy to severe dilatation of the heart. Identification of a single phenotype-associated
Van Der Velden J. +5 more
openaire +4 more sources
Bioprinting Organs—Science or Fiction?—A Review From Students to Students
Advanced Healthcare Materials, EarlyView.Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu +18 more
wiley +1 more source
Interactions between connected half-sarcomeres produce emergent mechanical behavior in a mathematical model of muscle. [PDF]
PLoS Computational Biology, 2009 Most reductionist theories of muscle attribute a fiber's mechanical properties to the scaled behavior of a single half-sarcomere. Mathematical models of this type can explain many of the known mechanical properties of muscle but have to incorporate a ...
Kenneth S Campbell
doaj +1 more source
Muscle in Variable Gravity: “I Do Not Know Where I Am, But I Know What to Do”
Frontiers in Physiology, 2021 Purpose: Fascicle and sarcomere lengths are important predictors of muscle mechanical performance. However, their regulation during stretch-shortening cycle (SSC) activities in usual and challenging conditions is poorly understood.
Elena Monti +12 more
doaj +1 more source
Redox Signaling and Cardiac Sarcomeres [PDF]
Journal of Biological Chemistry, 2011 Oxidative stress is common in many clinically important cardiac disorders, including ischemia/reperfusion, diabetes, and hypertensive heart disease. Oxidative stress leads to derangements in pump function due to changes in the expression or function of proteins that regulate intracellular Ca(2+) homeostasis.
Marius P, Sumandea, Susan F, Steinberg
openaire +2 more sources
The Space Within: How Architected Voids Promote Tissue Formation
Advanced Materials, EarlyView.This review explores the role of void spaces in tissue engineering scaffolds and examines four key methods for introducing porosity into hydrogels at different scales. It discusses sacrificial templating, microgels, phase separation, and 3D printing, highlighting principles, advantages, and limitations. It also addresses emerging strategies integrating
Anna Puiggalí‐Jou +3 more
wiley +1 more source
Sarcomeric dysfunction in heart failure [PDF]
Cardiovascular Research, 2007 Sarcomeric dysfunction plays a central role in reduced cardiac pump function in heart failure. This review focuses on the alterations in sarcomeric proteins in diseased myocardium that range from altered isoform expression to post-translational protein changes such as proteolysis and phosphorylation. Recent studies in animal models of heart failure and
Hamdani, N. +8 more
openaire +4 more sources
Biohybrid Actuators in Compact Arrangement with Embedded X Electrode
Advanced Robotics Research, EarlyView.Selective control of multimuscle biohybrid actuators is crucial for achieving complex movements of biohybrid robots. In this study, embedded X electrodes are fabricated to selectively control multiple muscles, realizing the robotic finger's bidirectional movements.
Tingyu Li, Minghao Nie, Shoji Takeuchi
wiley +1 more source
Imaging of zebrafish in vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin. [PDF]
PLoS ONE, 2011 We employed second-harmonic generation (SHG) imaging and the zebrafish model to investigate the myopathy caused by statin in vivo with emphasis on the altered microstructures of the muscle sarcomere, the fundamental contractile element of muscles.
Shih-Hao Huang +5 more
doaj +1 more source
Advanced Robotics Research, EarlyView.Muscle cell‐based biohybrid robot using nanomaterials for function enhancement and neural function for biomedical applications. Biohybrid robotics, an emerging field combining biological tissues with artificial systems, has made significant progress in developing various biohybrid constructs, including muscle‐cell‐driven biorobots and microbots.
Minkyu Shin +4 more
wiley +1 more source