Results 221 to 230 of about 79,406 (256)
Reduced Dietary Protein Induces Changes in the Dental Proteome
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs +2 more
wiley +1 more source
LKB1–AMPK Signaling Pathway in Cardiovascular and Other Diseases
The LKB1–AMPK pathway has a central regulatory role in various diseases. Dysfunction of this pathway can lead to pathological processes in cardiovascular diseases (atrial fibrillation, myocardial infarction, myocardial hypertrophy, atherosclerosis), metabolic diseases (diabetes and kidney disease), neurodegenerative diseases (Alzheimer's disease ...
Zhuo Chen, Qin Yang, Guo‐Wei He
wiley +1 more source
Heart Failure: Epidemiology, Pathophysiology, and Management
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan +9 more
wiley +1 more source
Cardiac aging promotes mitochondrial AGE accumulation driven by defective glycative stress detoxification. AGE‐modified mitochondria disrupt lysosomal proteolysis, impairing mitophagy and promoting lipofuscin buildup. This mechanism sustains chronic unresolved mitochondrial damage, driving proinflammatory senescence in cardiomyocytes and defining a ...
Diana Bou‐Teen +13 more
wiley +1 more source
Abstract Background The oxytocin receptor (OR) is a G‐protein‐coupled receptor recently identified in human spermatozoa, whose origin and role in sperm physiology remain unknown. Objectives In this study, using the pig as a model, we examine the presence of the OR in ejaculated spermatozoa through immunofluorescence and immunoblotting, and investigate ...
Jesús Martínez‐Hernández +9 more
wiley +1 more source
Carbohydrate Storage and Supplementation Strategies for Peak Performance in Cross‐Country Skiing
ABSTRACT Carbohydrates are essential for sustaining performance in most competitive exercise, fueling both anaerobic glycolysis during high‐intensity efforts and aerobic metabolism during prolonged activity. Numerous factors contribute to muscle fatigue and exercise performance; still, carbohydrate and muscle glycogen contents are agreed to have an ...
Niels Ørtenblad +3 more
wiley +1 more source
Abstract Extensive research in humans, dogs, rabbits, rats, mice and other mammals has consistently demonstrated that coronary blood flow (CBF) peaks during ventricular diastole. For example, studies using transthoracic Doppler echocardiography in anaesthetized rats and mice, isolated blood‐perfused rat hearts and Doppler probes sutured to the ...
Heidi L. Lujan +2 more
wiley +1 more source
Mapping the variability of in vivo rat uterine electrical properties throughout the oestrous cycle
Abstract After reaching sexual maturity, uterine function is driven by cyclical variations in hormone levels. The electrical and mechanical activity in the uterus varies during the menstrual cycle, contributing to essential functions such as sperm transport and shedding the menstrual lining.
Mathias W. Roesler +3 more
wiley +1 more source

