Results 161 to 170 of about 64,434 (204)
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Sarin intoxication elevates plasma pralidoxime
Toxicology Letters, 1985Groups of guinea pigs were injected with a range of dosages for sarin (0, 140, 279, 557 micrograms/kg) followed by pralidoxime (2-PAM) and atropine sulfate (16 mg/kg). Poisoning by sarin in these animals elevated plasma pralidoxime content in a dose-dependent manner within 10 min of intoxication.
M D, Green, D E, Jones, D E, Hilmas
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Sarin-induced neuropathology in rats
Human & Experimental Toxicology, 1995Sarin, a highly toxic cholinesterase (ChE) inhibitor, administered at near 1 LD50 dose causes severe signs of toxic cholinergic hyperactivity in both the peripheral and central nervous systems (CNS). The present study evaluated acute and long-term neuropathology following exposure to a single LD50 dose of sarin and compared it to lesions caused by ...
T, Kadar +5 more
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Journal of Chromatography B: Biomedical Sciences and Applications, 1997
A sarin-like organophosphorus agent, [bis(isopropyl methyl)phosphonate; BIMP], was synthesized. This agent has the same phosphonate group as sarin and also has the same anti-acetylcholinesterase activity potency as sarin. The ID50 and LD50 values of BIMP in mice after intravenous injection were 3.9 nM and 0.8 mg/kg, respectively. The AChE activities of
M, Nagao +7 more
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A sarin-like organophosphorus agent, [bis(isopropyl methyl)phosphonate; BIMP], was synthesized. This agent has the same phosphonate group as sarin and also has the same anti-acetylcholinesterase activity potency as sarin. The ID50 and LD50 values of BIMP in mice after intravenous injection were 3.9 nM and 0.8 mg/kg, respectively. The AChE activities of
M, Nagao +7 more
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Sarin Degradation Using Brucite
The Journal of Physical Chemistry C, 2011Density Functional Theory (DFT) calculations with periodic boundary conditions were used to investigate a degradation reaction mechanism of the Sarin molecule (isopropyl methylphosphonofluoridate, C4H10FO2P) using the layered hydroxide brucite (Mg(OH)2).
Viviane S. Vaiss +2 more
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Distal sensory axonopathy after sarin intoxication
Neurology, 1998A 51-year-old man inhaled sarin during a terrorist attack on the Tokyo subway system and died 15 months later. Neuropathologic examination revealed marked nerve fiber decrease in the sural nerve, moderate nerve fiber loss in the sciatic nerve, and unremarkable dorsal root ganglia, dorsal roots, and posterior column of the spinal cord. This pathology is
K, Himuro +7 more
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Accidental exposure to sarin: vision effects
Archives of Toxicology, 1985Two men were accidentally exposed to vapors of sarin, a cholinesterase inhibitor and extremely toxic nerve gas. Diagnosis was confirmed by depressed cholinesterase activity, and fixed extremely miotic pupils. No other signs or symptoms developed and neither man required treatment.
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THE ENZYMATIC HYDROLYSIS PRODUCTS OF SARIN
Canadian Journal of Biochemistry and Physiology, 1956The hydrolysis of the powerful cholinesterase inhibitor, sarin, by a rat serum enzyme leads almost exclusively to isopropyl methylphosphonic acid, neither methylphosphonic acid nor hydrogen methylphosphonofluoridate being formed. When isopropyl methylphosphonic acid is administered to the intact rat, it is excreted unchanged in the urine.
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