Results 171 to 180 of about 2,427 (237)

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

In Situ Assembly of Fluorogenic RNA for Screening Natural Anti‐Liver Fibrosis Products via Dynamic Visualization of COL1A1 mRNA

Advanced Science, EarlyView.
This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai, Li‐Zeng Zhu, Changfa Shao, Zheng Yin, Qun Liu, Yu Gu, Bin Liu   +6 more
wiley   +1 more source

Deciphering Cell Type Abundance in Proteomics Data Through Graph Neural Networks

Advanced Science, EarlyView.
GraphDEC constructs pseudo bulk reference data using a mixup strategy, then learns low dimensional representations via autoencoders to model intra and inter dataset relationships. These are processed through a multi view adaptive neighborhood aware GNN, integrating reference, target, and joint graphs.
Zhiming Dai, Yujie Song, Tuoshi Qi, Hongyu Zhang, Huiying Zhao, Zheng Wang, Yuedong Yang, Yuansong Zeng   +7 more
wiley   +1 more source

Real‐Time Self‐Optimization of Quantum Dot Laser Emissions During Machine Learning‐Assisted Epitaxy

Advanced Science, EarlyView.
This work presents a machine learning‐driven approach integrated with in situ high‐energy electron diffraction (RHEED) monitoring to automate the optimization of quantum dot (QD) growth for lasers. A 3.2‐fold increase in photoluminescence intensity is achieved alongside a narrow spectral linewidth.
Chao Shen, Wenkang Zhan, Shujie Pan, Hongyue Hao, Ning Zhuo, Kaiyao Xin, Hui Cong, Chi Xu, Bo Xu, Tien Khee Ng, Siming Chen, Chunlai Xue, Zhanguo Wang, Chao Zhao   +13 more
wiley   +1 more source

Twin Toughening‐Driven Martensitic Transformation Strategy Synergistic Improvement for Plasticity‐Thermal Shock Resistance of (Hf─Zr─Ti)C Ceramic Coating in Severe Thermal Environments

Advanced Science, EarlyView.
A “ceramic self‐toughening strategy” is introduced for enhancing the plasticity and thermal shock resistance of (Hf─Zr─Ti)C coatings through twin toughening‐driven martensitic transformations in oxide scales. It facilitated the formation of stable, dense, and high‐toughness oxide scales after repeat ablation, and endowed prepared coatings with superior
Jiachen Li, Yulei Zhang, Yanqin Fu, Tao Li, Jian Zhang, Deyu Yang, Lingfei Cao, Fanyu Lu, Junhao Zhao, Junshuai Lv, Hejun Li   +10 more
wiley   +1 more source

Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle

Advanced Science, EarlyView.
This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia, Fuwen Wang, Xiaoyu Luo, Shuang Li, Yang Lyu, Yining Zheng, Zhijie Ma, Kaixing Qu, Rende Song, Jianyong Liu, Jicai Zhang, Basang Wangdui, Basang Zhuzha, Suolang Quji, Li Zhao, Silang Wangmu, Ciren Luobu, Nima Cangjue, Danzeng Luosang, Suolang Sizhu, Haijian Cheng, Ruizhe Li, Zhipeng Wu, Ruihua Dang, Yongzhen Huang, Xianyong Lan, Luohao Xu, Haifei Hu, WaiYee Low, Zhuqing Zheng, Yu Wang, Yuanpeng Gao, Lu Deng, Johannes A. Lenstra, Jianlin Han, Xueyi Yang, Wenfa Lyu, Bizhi Huang, Chuzhao Lei, Ningbo Chen   +39 more
wiley   +1 more source

Antagonists to Neuromuscular Block Produced by Sarin

Experimental Biology and Medicine, 1956
Wills Jh, Monier Js, Kunkel Am
openaire   +3 more sources

From Ancient Techniques to Modern Solutions: In Situ Synthesis of C‐S‐H for Sandstone Conservation

Advanced Science, EarlyView.
Herein, this work presents a paleo‐inspired approach to synthesizing and optimizing C‐S‐H‐based grouting mortars for conserving the sandstone of Beishan Grottoes, Dazu Rock Carvings, China. By achieving an optimal recipe compatible with natural sandstone, this work demonstrates the pivotal role of hydrogen bonding in the adhesion between C‐S‐H mortars ...
Mengjun Jia, Huimin Yan, Qingqing Xu, Celestino Grifa, Gang Zhao, Siwei Jiang, Jinhua Wang, Zhenhua Wei, Han Liu, Xiao Ma   +9 more
wiley   +1 more source

In Situ Construction of Multi‐Functional Polymer Network Toward Durable Perovskite Solar Cells

Advanced Science, EarlyView.
Acrylamide monomers were introduced into the perovskite precursor solution to 3D polymer networks at grain boundaries for stabilizing grain boundaries. By constructing weak chemical bond interactions with perovskite films, the polymer networks effectively reduce defect density and simultaneously suppress the degradation of perovskites.
Bingqian Zhang, Qiangqiang Zhao, Kun Gao, Xiaoxu Zhang, Caiyun Gao, Xiuhong Sun, Hongpei Ji, Xiaopeng Feng, Yaliang Han, Xiaofei Yan, Xiao Wang, Zhipeng Shao, Shuping Pang, Kezheng Chen, Guanglei Cui   +14 more
wiley   +1 more source

PlantGPT: An Arabidopsis‐Based Intelligent Agent that Answers Questions about Plant Functional Genomics

Advanced Science, EarlyView.
PlantGPT integrates 60 000+ plant research articles with Arabidopsis phenotype‐gene data through retrieval‐augmented generation and fine‐tuning of Llama3‐8B. This open‐source, specialized AI system outperforms general large language models in plant gene‐phenotype relationships, establishing a new paradigm for functional genomics research and molecular ...
Ruixiang Zhang, Yu Wang, Weiyang Yang, Jun Wen, Weizhi Liu, Shipeng Zhi, Guangzhou Li, Nan Chai, Jiaqi Huang, Yongyao Xie, Xianrong Xie, Letian Chen, Miao Gu, Yao‐Guang Liu, Qinlong Zhu   +14 more
wiley   +1 more source