Results 31 to 40 of about 77,684 (384)

Effect of Atropine and the Oxime HI-6 on Low-Level Sarin-Induced Alteration of Performance of Rats in a T-Maze

Acta Medica, 2002
1. To study the influence of antidotes on low-level sarin-induced alteration of cognitive functions, male albino Wistar rats were exposed to three various low concentrations of sarin for 60 minutes in the inhalation chamber.
Gabriela Krejčová, Jiří Kassa, Josef Vachek   +2 more
doaj   +1 more source

Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme [PDF]

, 2010
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP ...
Andrew C. Hemmert, C. Linn Cadieux, Carol C. Edwards, Douglas M. Cerasoli, Fernando Rodrigues-Lima, John R. Cashman, Jonathan S. Edwards, Lyudmila Tsurkan, Matthew R. Redinbo, Monika Wierdl, Philip M. Potter, Roberto A. Chica, Shane A. Kasten, Stephen L. Mayo, Steven M. Lewis, Tamara C. Otto   +15 more
core   +6 more sources

A national toxicology program systematic review of the evidence for long-term effects after acute exposure to sarin nerve agent

Critical Reviews in Toxicology, 2020
Sarin is a highly toxic nerve agent that was developed for chemical warfare during World War II and is used in present conflicts. Immediate effects of acute sarin exposure are established; however, whether effects persist after initial signs have ...
D. Jett, Christopher A Sibrizzi, R. Blain, Pamela A Hartman, P. Lein, Kyla W. Taylor, Andrew A. Rooney   +6 more
semanticscholar   +1 more source

Long Term Effects of Low-Level Sarin Inhalation Exposure on the Spatial Memory of Rats in a T-Maze

Acta Medica, 2001
To study the influence of low-level sarin exposure on cognitive functions, male albino Wistar rats were exposed to three various low concentrations of sarin (LEVEL 1–3) for 60 minutes in the inhalation chamber.
Jiří Kassa, Marie Koupilová, Josef Vachek   +2 more
doaj   +1 more source

Search for Optimal Parameters for Gas Chromatographic Complex When Determining Sarin in Water Samples by Flame Photometric Detection Method

Вестник войск РХБ защиты, 2023
Sarin is considered to be an instrument for chemical terror by the extremist organizations due to the availability of technologies and components for its production.
V. А. Ignatyev, L. V. Petrakova, М. А. Ponsov, А. А. Rodionov   +3 more
doaj   +1 more source

The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats

BMC Pharmacology and Toxicology, 2018
Background The aim of our study was to compare the ability of two combinations of oximes (HI-6 + trimedoxime and HI-6 + K203) with atropine to counteract acute sarin-induced brain damage with the efficacy of antidotal treatment involving single oxime (HI-
Filip Caisberger, Jaroslav Pejchal, Jan Misik, Jiri Kassa, Martin Valis, Kamil Kuca   +5 more
doaj   +1 more source

ADMET and Druglikeness Calculations of Sarin, Soman, and Their Hypothetical Derivatives

Iraqi Journal of Industrial Research, 2022
Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) represents a numerical classification of any chemical to be a drug candidate with promising therapeutic efficacy with minimum toxicity or sensitivity depending on its chemical ...
Kafa Khalaf Hammud
doaj   +1 more source

The Tokyo subway sarin attack has long-term effects on survivors: A 10-year study started 5 years after the terrorist incident

PLoS ONE, 2020
Objectives The Tokyo subway sarin attack in 1995 was an unprecedented act of terrorism that killed 13 people and sickened more than 6,000. The long-term somatic and psychological effects on its victims remain unknown. Methods We conducted analyses on the
Aya Sugiyama, Toshihiko Matsuoka, Kazuaki Sakamune, T. Akita, R. Makita, Shinsuke Kimura, Yukio Kuroiwa, Masataka Nagao, J. Tanaka   +8 more
semanticscholar   +1 more source

Novel mutations and phenotypic associations identified through APC, MUTYH, NTHL1, POLD1, POLE gene analysis in Indian Familial Adenomatous Polyposis cohort

Scientific Reports, 2017
Colo-Rectal Cancer is a common cancer worldwide with 5–10% cases being hereditary. Familial Adenomatous Polyposis (FAP) syndrome is due to germline mutations in the APC or rarely MUTYH gene.
Nikhat Khan, Anuja Lipsa, Gautham Arunachal, Mukta Ramadwar, Rajiv Sarin   +4 more
doaj   +1 more source

The Long Term Changes in Liver DNA and Total Protein Contents Following Low Level Sarin Exposure in Rats

Acta Medica, 2000
1. The changes in contents of DNA and total protein in the liver of the rats exposed to low level sarin by inhalation at 3, 6 and 12 months following the exposure were studied.
Jiří Kassa, František Skopec, Josef Vachek   +2 more
doaj   +1 more source